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pro vyhledávání: '"Takuma Minamisono"'
Autor:
Takuma Minamisono, Hiroshi Takiyama
Publikováno v:
Journal of Crystal Growth. 362:135-139
Anti-solvent crystallization is widely used in the pharmaceutical industry for high yield production. However, addition methods to control polymorph in anti-solvent crystallization have not been discussed enough. In this study, indomethacin (IMC), wh
Autor:
Takuma Minamisono, Hiroshi Ishihara, Hiroshi Takiyama, Takashi Hasebe, Yoshiaki Sato, Takao Omae
Publikováno v:
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 45:233-238
Polymorphism is an interesting property of crystalline substances and is of importance in pharmaceutical development. Studies were conducted to identify the most stable of the five polymorphic (one hydrate and four anhydrous) forms of the active phar
Publikováno v:
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 44:197-202
Publikováno v:
Journal of pharmaceutical sciences. 101(1)
In order to better understand the oral absorption behavior of poorly water-soluble drugs, their supersaturation-nucleation behavior was characterized in fasted state simulated intestinal fluid. The induction time (t(ind)) for nucleation was measured