Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Takuma Tsuzuku"'
Autor:
Naoto Oku, Norihiro Harada, Kentaro Hatanaka, Hiroyuki Koide, Hidenori Ando, Tomohiro Asai, Hideo Tsukada, Norihito Yonenaga, Takuma Tsuzuku
Publikováno v:
YAKUGAKU ZASSHI. 132:1373-1381
In the development of nucleic acid medicines such as small interfering RNA (siRNA) drugs, one problem is how to study the pharmacokinetics and pharmacodynamics, since the precise in vivo behavior of siRNA is hard to detect. In this research, to estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed98d28958541bddbe2b52d66463c5b6
https://doi.org/10.1248/yakushi.12-00235-1
https://doi.org/10.1248/yakushi.12-00235-1
Autor:
Takehisa Dewa, Hiroshi Kikuchi, Takuma Tsuzuku, Kentaro Hatanaka, Hiroyuki Koide, Saori Matsushita, Tomohiro Asai, Noriyuki Maeda, Naoto Oku, Eriya Kenjo, Norihito Yonenaga, Mamoru Nango
Publikováno v:
Bioconjugate Chemistry. 22:429-435
Dicetyl phosphate-tetraethylenepentamine (DCP-TEPA) conjugate was newly synthesized and formed into liposomes for efficient siRNA delivery. Formulation of DCP-TEPA-based polycation liposomes (TEPA-PCL) complexed with siRNA was examined by performing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560446b78a07035e59b485b0a372f912
https://doi.org/10.1021/bc1004697
https://doi.org/10.1021/bc1004697
Autor:
Keiichi Furuya, Hiroki Kato, Mamoru Nango, Takehisa Dewa, Hiroyuki Koide, Takuma Tsuzuku, Naoto Oku, Tomohiro Asai, Noriyuki Maeda
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:602-608
Previously we developed dicetyl phosphate-tetraethylenepentamine-based polycation liposomes (TEPA-PCL) for use in small interfering RNA (siRNA) therapy. In the present study, mammalian target of rapamycin (mTOR) expression in cancer cells was silence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a87dd0f636f229de45baf095224e52
https://doi.org/10.1248/bpb.34.602
https://doi.org/10.1248/bpb.34.602
Autor:
Kentaro Hatanaka, Eriya Kenjo, Hiroyuki Koide, Hideo Tsukada, Tomohiro Asai, Naoto Oku, Norihiro Harada, Takuma Tsuzuku
Publikováno v:
Bioconjugate Chemistry. 21:756-763
Pharmacokinetic study of small interfering RNA (siRNA) is an important issue for the development of siRNAs for use as a medicine. For this purpose, a novel and favorable positron emitter-labeled siRNA was prepared by amino group-modification using N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710f01d66b0c8293bb43e4bc0305fd5d
https://doi.org/10.1021/bc9005267
https://doi.org/10.1021/bc9005267
Autor:
Naoto Oku, Hiroshi Ishihara, Mamoru Nango, Takehisa Dewa, Hiroshi Kikuchi, Tomohiro Asai, Ayaka Okamoto, Takuma Tsuzuku, Shoya Takahashi, Kenji Hyodo
Publikováno v:
Biochemical and biophysical research communications. 444(4)
Lipid nanoparticles (LNP) modified with cell-penetrating peptides (CPP) were prepared for the delivery of small interfering RNA (siRNA) into cells. Lipid derivatives of CPP derived from protamine were newly synthesized and used to prepare CPP-decorat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9a9d1dd9a2436b5fa20c8319d32752
https://pubmed.ncbi.nlm.nih.gov/24486551
https://pubmed.ncbi.nlm.nih.gov/24486551
Autor:
Hidenori, Ando, Norihito, Yonenaga, Tomohiro, Asai, Kentaro, Hatanaka, Hiroyuki, Koide, Takuma, Tsuzuku, Norihiro, Harada, Hideo, Tsukada, Naoto, Oku
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 132(12)
In the development of nucleic acid medicines such as small interfering RNA (siRNA) drugs, one problem is how to study the pharmacokinetics and pharmacodynamics, since the precise in vivo behavior of siRNA is hard to detect. In this research, to estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d29790788feb641ae9f7fcd2cca036bc
https://pubmed.ncbi.nlm.nih.gov/23208044
https://pubmed.ncbi.nlm.nih.gov/23208044
Autor:
Tomohiro Asai, Saori Matsushita, Eriya Kenjo, Takuma Tsuzuku, Norihito Yonenaga, Hiroyuki Koide, Kentaro Hatanaka, Takehisa Dewa, Mamoru Nango, Noriyuki Maeda, Hiroshi Kikuchi, Naoto Oku
Publikováno v:
Bioconjugate Chemistry; Mar2011, Vol. 22 Issue 3, p429-435, 7p