Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Takuji Oyama"'
Autor:
Shotaro Kamata, Akihiro Honda, Ryo Ishikawa, Makoto Akahane, Ayane Fujita, Chihiro Kaneko, Saeka Miyawaki, Yuki Habu, Yui Shiiyama, Kie Uchii, Yui Machida, Takuji Oyama, Isao Ishii
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1523 (2023)
No therapeutic drugs are currently available for nonalcoholic steatohepatitis (NASH) that progresses from nonalcoholic fatty liver via oxidative stress-involved pathways. Three cognate peroxisome proliferator-activated receptor (PPAR) subtypes (PPAR
Externí odkaz:
https://doaj.org/article/0accaf46209a47e383198c9c9eddc003
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100364- (2021)
Summary: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor-type transcription factors with three subtypes (α, δ, and γ) that regulate cell differentiation and metabolism. Co-crystals of human PPARα-ligand-binding domain (LB
Externí odkaz:
https://doaj.org/article/53ce7e7731544411be941c2d5ade6d26
Autor:
Shotaro Kamata, Takuji Oyama, Kenta Saito, Akihiro Honda, Yume Yamamoto, Keisuke Suda, Ryo Ishikawa, Toshimasa Itoh, Yasuo Watanabe, Takahiro Shibata, Koji Uchida, Makoto Suematsu, Isao Ishii
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101727- (2020)
Summary: Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been dep
Externí odkaz:
https://doaj.org/article/019e9a2e669140bd9f38f82355fbf354
Autor:
Takuji Oyama, George E Schmitz, Dylan Dodd, Yejun Han, Alanna Burnett, Naoko Nagasawa, Roderick I Mackie, Haruki Nakamura, Kosuke Morikawa, Isaac Cann
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80448 (2013)
CpMan5B is a glycoside hydrolase (GH) family 5 enzyme exhibiting both β-1,4-mannosidic and β-1,4-glucosidic cleavage activities. To provide insight into the amino acid residues that contribute to catalysis and substrate specificity, we solved the s
Externí odkaz:
https://doaj.org/article/9323d4d152d343f0b023634788d4a810
Autor:
Takuji Oyama, Keishi Narita
Publikováno v:
Protein & Peptide Letters. 29:971-978
Background: Hoatz is a vertebrate-specific gene, the defects of which result in hydrocephalus and oligo-astheno-teratozoospermia in mice. It encodes a 19-kDa protein lacking any domains of known function. Methods: To understand the protein activity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bb5b9fc322e1b8e001f9dbf10b3109
https://doi.org/10.2174/0929866529666220912115544
https://doi.org/10.2174/0929866529666220912115544
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:390-398
The ribonuclease (RNase) H family of enzymes catalyze the specific cleavage of RNA strands of RNA/DNA hybrid duplexes and play an important role in DNA replication and repair. Since the first report of the crystal structure of RNase HI, its catalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8019ec6bcca0f9d4faee44c50bab1f3d
https://doi.org/10.1107/s2059798322000870
https://doi.org/10.1107/s2059798322000870
Autor:
Takuji Oyama
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(12)
Peroxisome proliferator-activated receptors (PPARs) are transcription factors that are activated by endogenous fatty acids and synthetic compounds as ligands. We have been developing new phenylpropanoic acid derivatives based on structure-activity re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a2c118047424abf3bb4722e302621f
https://pubmed.ncbi.nlm.nih.gov/36450513
https://pubmed.ncbi.nlm.nih.gov/36450513
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 78(Pt 2)
Peroxisome proliferator-activated receptor δ (PPARδ) is a member of the nuclear receptor family and regulates glucose and lipid homeostasis in a ligand-dependent manner. Numerous phenylpropanoic acid derivatives targeting three PPAR subtypes (PPAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175d54155a6dfc0430a73ac7577b75ba
https://pubmed.ncbi.nlm.nih.gov/35102897
https://pubmed.ncbi.nlm.nih.gov/35102897
Autor:
Takuji Oyama, Mariko Nagata, Takeshi Yamagami, Yoshizumi Ishino, Keisuke Oki, Tomoyuki Numata, Sonoko Ishino
Publikováno v:
Nucleic acids research. 50(7)
Genomic DNA replication requires replisome assembly. We show here the molecular mechanism by which CMG (GAN–MCM–GINS)-like helicase cooperates with the family D DNA polymerase (PolD) in Thermococcus kodakarensis. The archaeal GINS contains two Gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bf16edc5ed575033c312a408ede657
https://pubmed.ncbi.nlm.nih.gov/34568951
https://pubmed.ncbi.nlm.nih.gov/34568951
Publikováno v:
Biologicalpharmaceutical bulletin. 44(9)
Peroxisome proliferator-activated receptor (PPAR)α, a member of the nuclear receptor family, is a transcription factor that regulates the expression of genes related to lipid metabolism in a ligand-dependent manner, and has attracted attention as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3fe53e8a2f0e51fbabf84d34b6e4e7
https://pubmed.ncbi.nlm.nih.gov/34471048
https://pubmed.ncbi.nlm.nih.gov/34471048