Výsledky vyhledávání - "Takuji Hosoya"

Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice

Autor: Shigeru Shibata, Koji Matsumoto, Naoko H. Tomioka, Takuji Hosoya, Shunya Uchida, Makoto Hosoyamada

Publikováno v: Journal of the American Society of Nephrology. 33:326-341

Background Hereditary renal hypouricemia type-1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced acute kidney injury (EIAKI). Because, however, there is no useful experimental RHUC1 animal model, the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6361a9c2c62ad553de8590f6f7163639
https://doi.org/10.1681/asn.2021050616

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Perfecting a high hypoxanthine phosphoribosyltransferase activity–uricase KO mice to test the effects of purine‐ and non‐purine‐type xanthine dehydrogenase (XDH) inhibitors

Autor: Shunya Uchida, Naoko H. Tomioka, Takuji Hosoya, Shigeru Shibata, Makoto Hosoyamada

Publikováno v: Br J Pharmacol

BACKGROUND AND PURPOSE: Purine metabolism in mice and human differ in terms of uricase (Uox) activity as well as hypoxanthine phosphoribosyltransferase (HPRT) activity. The aim of this study was the establishment of high HPRT activity–Uox knockout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb816d01794eeb3cf7c53cd4c5df914
https://doi.org/10.1111/bph.14978

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Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity

Autor: Takuji, Hosoya, Shunya, Uchida, Shigeru, Shibata, Naoko H, Tomioka, Koji, Matsumoto, Makoto, Hosoyamada

Publikováno v: J Am Soc Nephrol

BACKGROUND: Hereditary renal hypouricemia type 1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI). However, because there is no useful experimental RHUC1 animal model, the precise pathophysio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0339bc16635e10bb3fdc1fd71af7ca6b
https://pubmed.ncbi.nlm.nih.gov/34799437

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TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice

Autor: Hiroyuki Nakamura, Syunji Horie, Toshihiko Murayama, Takuji Hosoya, Hiromichi Fujino, Kenjiro Matsumoto, Kimihito Tashima

Publikováno v: Neurogastroenterology & Motility. 26:1112-1121

Background Transient receptor potential channel melastatin 8 (TRPM8) is activated by cold temperatures and cooling agents (menthol and icilin). Recent studies showed TRPM8 is expressed in visceral organs and peripheral sensory pathways. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49638bc073ab4ac6c3402640eb4945cf
https://doi.org/10.1111/nmo.12368

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Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice

Autor: Kenjiro Matsumoto, Hiromitsu Takayama, Takuji Hosoya, Syunji Horie, Toshihiko Murayama, Kimihito Tashima, Mee Wah Lo

Publikováno v: Laboratory Investigation. 92:769-782

Abnormalities of primary afferent nerve fibers are strongly associated with the visceral hypersensitivity state in inflammatory bowel disease. Hypersensitivity of afferent fibers occurs during inflammation. Therefore, to gain an insight into the alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f046d2c99d1c72466b6e4418c6957c9c
https://doi.org/10.1038/labinvest.2012.14

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Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon

Autor: Toshihiko Murayama, Emi Kurosawa, Kenjiro Matsumoto, Takuji Hosoya, Syunji Horie, Hiroyuki Terui, Kimihito Tashima, John V. Priestley

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 297:G348-G360

We investigated immunohistochemical differences in the distribution of TRPV1 channels and the contractile effects of capsaicin on smooth muscle in the mouse rectum and distal, transverse, and proximal colon. In the immunohistochemical study, TRPV1 im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7be289f880114c239337839803dfb41
https://doi.org/10.1152/ajpgi.90578.2008

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Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus

Autor: Kimihito Tashima, Kenjiro Matsumoto, Toshihiko Murayama, Kikuko Amagase, Syunji Horie, Shinichi Kato, Eriko Ishikawa, Takuji Hosoya

Publikováno v: Histochemistry and cell biology. 142(6)

Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a role in esophageal function. However, the distribution of TRPV1 nerve fibers in the esophagus is currently not well understood. In the present study, we investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ae89a28e0df8a2c26ebab717ae20e7
https://pubmed.ncbi.nlm.nih.gov/25002127

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