Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Taku Kodama"'
Autor:
Nobuaki Miyahara, Christian Taube, Xu Dong Wei, Katsuyuki Takeda, Rhi Hua Fan, Anthony Joetham, Kosuke Chayama, Jung Won Park, Annette Balhorn, Alberto Alvarez, Erwin W. Gelfand, Christina H. Swasey, Taku Kodama, Azzeddine Dakhama
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 170:952-959
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis during infancy and is associated with subsequent wheezing and asthma, but the nature of this association is not fully understood. We investigated the role of RSV-specific IgE
Autor:
Bradley J. Swanson, Katsuyuki Takeda, Erwin W. Gelfand, Vanessa L. Ott, Taku Kodama, Christian Taube, Nobuaki Miyahara, Azzeddine Dakhama, Satoko Miyahara
Publikováno v:
Nature Medicine. 10:865-869
Allergic asthma is a complex syndrome characterized by airway obstruction, airway inflammation and airway hyper-responsiveness (AHR). Using a mouse model of allergen-induced AHR, we previously demonstrated that CD8-deficient mice develop significantl
Autor:
Christina H. Swasey, Nobuaki Miyahara, Katsuyuki Takeda, Corrie B. Allen, Charles A. Dinarello, Anthony Joetham, Soohyun Kim, Annette Balhorn, Jung Won Park, Christian Taube, Erwin W. Gelfand, Azzeddine Dakhama, Taku Kodama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 30:830-836
The role of an interleukin (IL)-1 receptor antagonist (IL-1Ra) on the development of airway hyperresponsiveness (AHR) and airway inflammation following acute O(3) exposure in mice was investigated. Exposure of C57/BL6 mice to O(3) at a concentration
Autor:
Lenny D. Shultz, Azzeddine Dakhama, Nobuaki Miyahara, Debra D. Donaldson, Simona Zarini, Eckard Hamelmann, Joan E. Loader, Katsuyuki Takeda, Xudong Wei, Tricia N. Lively, Taku Kodama, Christian Taube, Erwin W. Gelfand, Anthony Joetham, Christina H. Swasey
Publikováno v:
The Journal of Immunology. 172:6398-6406
In certain models of allergic airway disease, mast cells facilitate the development of inflammation and airway hyper-responsiveness (AHR). To define the role of the high affinity IgE receptor (FcεRI) in the development of AHR, mice with a disruption
Autor:
Katsuyuki Takeda, Nobuaki Miyahara, Anthony Joetham, Azzeddine Dakhama, Catherine Duez, Amanda Evans, Erwin W. Gelfand, Taku Kodama, Eun Seok Yang, Dennis R. Voelker, Annette Balhorn, Yeong Ho Rha, Christian Taube
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 168:783-789
The lung collectin surfactant protein D (SP-D) is an important component of the innate immune response but is also believed to play a role in other regulatory aspects of immune and inflammatory responses within the lung. The role of SP-D in the devel
Publikováno v:
Annals of Nutrition and Metabolism. 47:165-169
Background: Pipecolic acid, a metabolite of lysine, is found in human physiological fluids and is thought to play an important role in the central inhibitory γ-aminobutyric acid system. However, it is unclear whether plasma D- and L-pipecolic acid o
Publikováno v:
Clinical & Experimental Allergy. 32:641-649
Summary Background Correcting Th1/Th2 imbalance with administration of IL-12 before and during antigen challenge holds therapeutic promise in asthma. However, the effects of IL-12 on the established asthmatic responses have not fully been examined. O
Autor:
Minoru Sugita, Tomohiro Matsuyama, Osamu Kitada, M. Fujita, Kozo Kuribayashi, Daizo Ihaku, Taku Kodama
Publikováno v:
Clinical & Experimental Allergy. 31:1470-1477
Background and objective Carbon monoxide (CO) is known to be present in measurable quantities in the exhalation of asthmatic patients. Corticosteroid treatment resulted in a decrease in exhaled CO levels in asthmatic patients, raising the possibility
Autor:
Shizuo Akira, Taku Kodama, Kenji Nakanishi, Kozo Kuribayashi, Haruki Okamura, Minoru Sugita, Tomohiro Matsuyama, Yasuhiro Nishioka
Publikováno v:
Journal of Allergy and Clinical Immunology. 105:45-53
Background: T H2 cytokines are associated with airway inflammation and hyperreactivity in bronchial asthma, and restoration of the T H1 /T H2 imbalance is a potential avenue for novel therapies. IL-18 is a cytokine secreted by activated macrophages,
Autor:
Kiyoshi Takeda, Shin-ichiro Kashiwamura, Tomohiro Matsuyama, Kozo Kuribayashi, Tohru Tsujimura, Katsuaki Hoshino, Kenji Nakanishi, Taku Kodama, Shizuo Akira
Publikováno v:
The Journal of Experimental Medicine
T1/ST2, an orphan receptor with homology with the interleukin (IL)-1 receptor family, is expressed constitutively and stably on the surface of T helper type 2 (Th2) cells, but not on Th1 cells. T1/ST2 is also expressed on mast cells, which are critic