Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Taku Kitanaka"'
Autor:
Junichi Nunomura, Rei Nakano, Atsuto Naruke, Yoko Suwabe, Masumi Nakano, Naoya Yachiku, Manami Kuji, Mana Sugimura, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0278220 (2022)
Melanoma shows highly aggressive behavior (i.e., local invasion and metastasis). Matrix metalloprotease-3 (MMP-3), a zinc-dependent endopeptidase, degrades several extracellular substrates and contributes to local invasion by creating a microenvironm
Externí odkaz:
https://doaj.org/article/bb3bd0f0623a41d888ef5d22b5dbbf8f
Autor:
Yoko Suwabe, Rei Nakano, Shinichi Namba, Naoya Yachiku, Manami Kuji, Mana Sugimura, Nanako Kitanaka, Taku Kitanaka, Tadayoshi Konno, Hiroshi Sugiya, Tomohiro Nakayama
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0243859 (2021)
The rate of glucose uptake dramatically increases in cancer cells even in the presence of oxygen and fully functioning mitochondria. Cancer cells produce ATP by glycolysis rather than oxidative phosphorylation under aerobic conditions, a process term
Externí odkaz:
https://doaj.org/article/da1cad3bfffd4c8e807298c0533b1b2c
Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
Autor:
Atsuto Naruke, Rei Nakano, Junichi Nunomura, Yoko Suwabe, Masumi Nakano, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
In autoimmune diseases, fibroblasts produce and secrete various cytokines and act as sentinel immune cells during inflammatory states. However, the contribution of sentinel immune cells (i.e. dermal fibroblasts) in autoimmune diseases of the skin, su
Externí odkaz:
https://doaj.org/article/941ace733fc6433ab24a305864a622d9
Autor:
Rei Nakano, Taku Kitanaka, Shinichi Namba, Nanako Kitanaka, Yoko Suwabe, Tadayoshi Konno, Jun Yamazaki, Tomohiro Nakayama, Hiroshi Sugiya
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The pro-inflammatory cytokine interleukin 1β (IL-1β) induces the synthesis of prostaglandin E2 by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA). IL-1β-mediat
Externí odkaz:
https://doaj.org/article/bb41b6df530040598eaf5d8bc50e0f4d
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Feline degenerative joint disease (DJD) has been reported worldwide. Radiographic evidence, including that from single-plane radiographs, has been used for diagnosis in these reports, though orthogonal radiographs are generally required to diagnose D
Externí odkaz:
https://doaj.org/article/64e95b276a2e4c059651cbb23e4f8032
Autor:
Rei Nakano, Taku Kitanaka, Shinichi Namba, Nanako Kitanaka, Masaki Sato, Yoshiyuki Shibukawa, Yoshikazu Masuhiro, Koichiro Kano, Taro Matsumoto, Hiroshi Sugiya
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229892 (2020)
The specification of cell identity depends on the exposure of cells to sequences of bioactive ligands. All-trans retinoic acid (ATRA) affects neuronal development in the early stage, and it is involved in neuronal lineage reprogramming. We previously
Externí odkaz:
https://doaj.org/article/31899602ae724d0cb4c1c4dd946b9117
Autor:
Nanako Kitanaka, Rei Nakano, Manabu Sakai, Taku Kitanaka, Shinichi Namba, Tadayoshi Konno, Tomohiro Nakayama, Hiroshi Sugiya
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222869 (2019)
Matrix metalloproteinases (MMPs) play a pivotal role in tissue remodeling by degrading the extracellular matrix (ECM) components. This mechanism is implicated in a variety of physiological and pathological cellular processes including wound healing.
Externí odkaz:
https://doaj.org/article/8124cdb2fe9942849fde0fa38af00fe9
Autor:
Nanako Kitanaka, Rei Nakano, Kanae Sugiura, Taku Kitanaka, Shinichi Namba, Tadayoshi Konno, Tomohiro Nakayama, Hiroshi Sugiya
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0220262 (2019)
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the immune response and inflammation. In this study, we investigated effect of the proinflammatory cytokine interleukin-1β (IL-1β) on IL-6 expression in canine dermal fibr
Externí odkaz:
https://doaj.org/article/21981636e99c4de588352e5c0e68224a
Autor:
Nanako Kitanaka, Rei Nakano, Taku Kitanaka, Shinichi Namba, Tadayoshi Konno, Tomohiro Nakayama, Hiroshi Sugiya
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208955 (2018)
Inflammatory and microenvironmental factors produced by cancer cells are thought to directly or indirectly promote cancer cell growth. Prostaglandins, including prostaglandin E2, have key roles as a microenvironment factor in influencing the developm
Externí odkaz:
https://doaj.org/article/a659769962d24ec1b8dcc1d17d7b52f2
Autor:
Shinichi Namba, Rei Nakano, Taku Kitanaka, Nanako Kitanaka, Tomohiro Nakayama, Hiroshi Sugiya
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182923 (2017)
Tumor necrosis factor α (TNF-α) induces the expression and secretion of interleukin 8 (IL-8), which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the onset of RA, we used synovial fibroblasts without autoimmun
Externí odkaz:
https://doaj.org/article/fd110782acae4b74a97cbe89c8ef6412