Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Taku Arano"'
Autor:
Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 218-227 (2017)
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra. However, the molecular relationship between p150Glue
Externí odkaz:
https://doaj.org/article/85235ce739fc410eb83359e049f8ca99
Autor:
Yuzuru Imai, Yoshito Kobayashi, Tsuyoshi Inoshita, Hongrui Meng, Taku Arano, Kengo Uemura, Takeshi Asano, Kenji Yoshimi, Chang-Liang Zhang, Gen Matsumoto, Toshiyuki Ohtsuka, Ryoichiro Kageyama, Hiroshi Kiyonari, Go Shioi, Nobuyuki Nukina, Nobutaka Hattori, Ryosuke Takahashi
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005503 (2015)
Leucine-rich repeat kinase 2 (LRRK2) is a key molecule in the pathogenesis of familial and idiopathic Parkinson's disease (PD). We have identified two novel LRRK2-associated proteins, a HECT-type ubiquitin ligase, HERC2, and an adaptor-like protein w
Externí odkaz:
https://doaj.org/article/715ded3cb98a4c34aa4c641abed42e56
Autor:
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004861 (2014)
The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondri
Externí odkaz:
https://doaj.org/article/fe100669f56a46c7950072279f3e37e0
Autor:
Yuka Hosaka, Takako Morimoto, Yujiro Umezaki, Taku Arano, Hongrui Meng, Tsuyoshi Inoshita, Yuzuru Imai, Hui-Yun Chang, Nobutaka Hattori, Sakiko Kosugi, Masato Koike
Publikováno v:
Human Molecular Genetics. 26:2933-2948
Mutations of the retromer component Vps35 and endosomal kinase LRRK2 are linked to autosomal dominant forms of familial Parkinson's disease (PD). However, the physiological and pathological roles of Vps35 and LRRK2 in neuronal functions are poorly un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fc43f2d07da134f23160eb0df425e9
https://doi.org/10.1093/hmg/ddx179
https://doi.org/10.1093/hmg/ddx179
Publikováno v:
Advances in experimental medicine and biology. 997
Parkinson's disease (PD) is a common neurodegenerative disorder, with ageing being a major risk factor. Accordingly, estimates predict an increasing number of PD patients due to our expanding life span. Consequently, developing a true disease-modifyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d3371594ca4f5ec44f7f3e586397f38
https://pubmed.ncbi.nlm.nih.gov/28815529
https://pubmed.ncbi.nlm.nih.gov/28815529
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811045660
Parkinson’s disease (PD) is a common neurodegenerative disorder, with ageing being a major risk factor. Accordingly, estimates predict an increasing number of PD patients due to our expanding life span. Consequently, developing a true disease-modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da89f098b1feeb83ab18c88338e5b7f0
https://doi.org/10.1007/978-981-10-4567-7_12
https://doi.org/10.1007/978-981-10-4567-7_12
Publikováno v:
Neurochemistry International. 71:22-35
Addicsin is a novel factor encoding a 23-kDa hydrophobic protein that is highly upregulated in the amygdala nuclei of morphine-administered mice. It is a murine homolog of human JWA and rat glutamate transporter-associated protein 3-18 (GTRAP3-18), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4564c91702cf51c71a443b3e914633
https://doi.org/10.1016/j.neuint.2014.03.011
https://doi.org/10.1016/j.neuint.2014.03.011
Autor:
Taku Arano, Yuzuru Imai
Publikováno v:
Cell Death-Autophagy, Apoptosis and Necrosis
Mitochondria play key roles in the cellular metabolism of lipids and iron as well as in cell death signaling. Mitochondrial dysregulation produces reactive oxygen species (ROS), which results in oxidative stress. Moreover, the accumulation of damaged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5e816a8bd40b0a90c0b77e5382229c
http://www.intechopen.com/articles/show/title/mitophagy-regulated-by-the-pink1-parkin-pathway
http://www.intechopen.com/articles/show/title/mitophagy-regulated-by-the-pink1-parkin-pathway
Autor:
Taku Arano, Mitsushi Ikemoto
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). In addition to functioning as a neurotransmitter at the majority of brain synapses, it is the substrate for synthesis of the major inhibitory transmitte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::854c39f41b1eeaa88627d2678939b4d5
https://doi.org/10.5772/33889
https://doi.org/10.5772/33889
Autor:
Toshiyuki Ohtsuka, Go Shioi, Yoshito Kobayashi, Taku Arano, Ryosuke Takahashi, Tsuyoshi Inoshita, Hongrui Meng, Gen Matsumoto, Nobutaka Hattori, Chang Liang Zhang, Yuzuru Imai, Kenji Yoshimi, Nobuyuki Nukina, Takeshi Asano, Ryoichiro Kageyama, Hiroshi Kiyonari, Kengo Uemura
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005503 (2015)
PLoS Genetics
PLoS Genetics
Leucine-rich repeat kinase 2 (LRRK2) is a key molecule in the pathogenesis of familial and idiopathic Parkinson’s disease (PD). We have identified two novel LRRK2-associated proteins, a HECT-type ubiquitin ligase, HERC2, and an adaptor-like protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f5c7ceaecc91efb6c0e358b49d5c4b
https://doi.org/10.1371/journal.pgen.1005503
https://doi.org/10.1371/journal.pgen.1005503