Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Taku Amano"'
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 7, Iss 1, Pp 34-44 (2017)
Yokukansan, a traditional Japanese herbal medicine, has been considered to be a novel alternative treatment for several neurological diseases such as neurodegenerative disorders, as well as neurosis, insomnia, and behavioral and psychological symptom
Externí odkaz:
https://doaj.org/article/ec56a1c86ab04108870d2679a792dd75
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 2, Pp 203-206 (2013)
Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na+ cu
Externí odkaz:
https://doaj.org/article/eb6c65f1480c450cbebc45aed6f79c08
Autor:
Takahiro Seki, Takayuki Shimahara, Kazuhiro Yamamoto, Nana Abe, Taku Amano, Naoko Adachi, Hideyuki Takahashi, Kaori Kashiwagi, Naoaki Saito, Norio Sakai
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 2, Pp 260-273 (2009)
Missense mutations in protein kinase Cγ (γPKC) gene have been found in spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease. We previously demonstrated that mutant γPKC found in SCA14 is susceptible to aggregatio
Externí odkaz:
https://doaj.org/article/1be24711b0f94db1a827ea207c672705
Autor:
Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 4, Pp 392-404 (2009)
We investigated the effects of brefeldin A and ilimaquinone, inhibitors of membrane trafficking, using serotonin transporter (SERT)–expressing COS-7 cells. Both drugs significantly inhibited the serotonin uptake activity of SERT and caused SERT to
Externí odkaz:
https://doaj.org/article/8b3edcb3627f4851a9fcd9e4c3ec6978
Autor:
Taku Amano, Zhu Aihua, Hiroaki Matsubayashi, Takahiro Seki, Tadao Serikawa, Masashi Sasa, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 3, Pp 355-362 (2004)
We investigated the effects of single and repeated administrations of S-312-d (methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)-thieno-[2,3-b]pyridine-5-carboxylate), a newly synthesized L-type Ca2+-channel blocker, on tonic convulsions and a
Externí odkaz:
https://doaj.org/article/e87b11ef036a49f1816b22ad3dd62509
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 1, Pp 114-117 (2003)
ABSTRACT: To investigate the effect of cis-N-[4-[4-(1,2-benz-isozole-3-yl)-1-piperazinyl]butyl] cyclohexane-1,2-dicarboximide hydrochloride (perospirone), a novel antipsychotic agent with high affinities for D2/5-HT2 receptors, on the rat dorsal raph
Externí odkaz:
https://doaj.org/article/7be5b5f737984d3690e15fc8fa528018
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 2, Pp 143-148 (2003)
ABSTRACT: The electrophysiological characteristics of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra was investigated using the whole-cell patch clamp technique under the voltage-clamp mode. Nicotine (0.01 – 100 μM
Externí odkaz:
https://doaj.org/article/189fbea01acf43d5b404dc906d67d4e2
Publikováno v:
Psychopharmacology. 239:3133-3143
It is known that both selective serotonin and serotonin noradrenaline reuptake inhibitors (SSRI, SNRI) are first-line drugs for the treatment of major depressive disorder. It has also been considered that both SSRI and SNRI can improve the symptoms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945d5ccdc198417e807bb979dba70664
https://doi.org/10.1007/s00213-022-06194-6
https://doi.org/10.1007/s00213-022-06194-6
Autor:
Yoshihiko Nakatani, Kanami Ishikawa, Yuko Aoki, Takahiro Shimooki, Naoki Yamamoto, Taku Amano
Publikováno v:
Pharmacological Reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e06b8e1662110b94b0a2682431b695c6
https://doi.org/10.1007/s43440-023-00477-1
https://doi.org/10.1007/s43440-023-00477-1
Autor:
Yoshihiko Nakatani, Taku Amano
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc5659cdc4bd857d9c9764e24dbac734
https://doi.org/10.1254/jpssuppl.95.0_1-p-088
https://doi.org/10.1254/jpssuppl.95.0_1-p-088