Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Taku, Yoshida"'
Autor:
Ayumi Tachibana, Jun-ichi Iga, Tomoki Ozaki, Yuta Yoshino, Kiyohiro Yamazaki, Shinichiro Ochi, Kentaro Kawabe, Fumie Horiuchi, Taku Yoshida, Hideaki Shimizu, Takaaki Mori, Yasuko Tatewaki, Yasuyuki Taki, Toshiharu Ninomiya, Shu-ichi Ueno
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The frequency of behavioral and psychological symptoms of dementia (BPSD) is high, and it is a challenge to elucidate its neural substrates underlying their development. In recent years, many findings have been reported on the relationship b
Externí odkaz:
https://doaj.org/article/528a32c56b1a486db3debbb2eb8e5cc4
Autor:
Ayumi Tachibana, Jun-ichi Iga, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-ichi Ueno, the JPSC-AD study group
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, the evidence for the relationship between serum-hs-CRP and dementia including AD a
Externí odkaz:
https://doaj.org/article/afdeb1252aef4f18b812dd9b588c3c6b
Autor:
Emi Sugimoto, Jingmei Li, Yasutaka Hayashi, Kohei Iida, Shuhei Asada, Tsuyoshi Fukushima, Moe Tamura, Shiori Shikata, Wenyu Zhang, Keita Yamamoto, Kimihito Cojin Kawabata, Tatsuya Kawase, Takeshi Saito, Taku Yoshida, Satoshi Yamazaki, Yuta Kaito, Yoichi Imai, Tamami Denda, Yasunori Ota, Tomofusa Fukuyama, Yosuke Tanaka, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we found that the development of several aggressive subtypes of AML is slower in Rag2 −/− mic
Externí odkaz:
https://doaj.org/article/5b6b8d5e72fb4e78b3b3547dd6332877
Autor:
Shohei Harabuchi, Omar Khan, Hamid Bassiri, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Akihiro Katada, Taku Kambayashi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionActivation of T cell receptor (TCR) signaling is critical for clonal expansion of CD8+ T cells. However, the effects of augmenting TCR signaling during chronic antigen exposure is less understood. Here, we investigated the role of diacylg
Externí odkaz:
https://doaj.org/article/e0860c9208fd4250ad3c790230b9590a
Autor:
Yuta Yoshino, Hiroshi Kumon, Takaaki Mori, Taku Yoshida, Ayumi Tachibana, Hideaki Shimizu, Jun-ichi Iga, Shu-ichi Ueno
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Alanine:glyoxylate aminotransferase 2 (AGXT2; EC 2.6.1.44) is the only enzyme that degrades the R-form of 3-aminoisobutyrate, an intermediate metabolite of thymine. AGXT2, as well as diaminoarginine dimethylaminohydrolase 1 (DDAH1
Externí odkaz:
https://doaj.org/article/3c8d632676404972be43a90a73e7d8cd
Autor:
Yukie Kashima, Yosuke Togashi, Shota Fukuoka, Takahiro Kamada, Takuma Irie, Ayako Suzuki, Yoshiaki Nakamura, Kohei Shitara, Tatsunori Minamide, Taku Yoshida, Naofumi Taoka, Tatsuya Kawase, Teiji Wada, Koichiro Inaki, Masataka Chihara, Yukihiko Ebisuno, Sakiyo Tsukamoto, Ryo Fujii, Akihiro Ohashi, Yutaka Suzuki, Katsuya Tsuchihara, Hiroyoshi Nishikawa, Toshihiko Doi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Single-cell level analysis is powerful tool to assess the heterogeneity of cellular components in tumor microenvironments (TME). In this study, we investigated immune-profiles using the single-cell analyses of endoscopically- or surgically-r
Externí odkaz:
https://doaj.org/article/ed447e8d5e6c46eab303d092243a0a34
Autor:
Yuta Yoshino, Taku Yoshida, Hideo Morino, Masayuki Nakamura, Masao Abe, Hokuto Omachi, Saori Inoue, Yukiyo Miyoshi, Yumina Tachibana, Noriko Yamauchi, Naoya Takeda, Mutsuhiko Mizobuchi, Yuki Ozaki, Shinichiro Ochi, Junichi Iga, Shu-ichi Ueno
Publikováno v:
BMC Psychiatry, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background We recently reported that older patients with schizophrenia (SZ) show possible idiopathic normal pressure hydrocephalus (iNPH) more frequently than the general population. In this study, we estimated the prevalence of iNPH in a la
Externí odkaz:
https://doaj.org/article/12c4b7e5410247f48404043019aed105
Autor:
Takayuki Tabira, Maki Hotta, Miki Murata, Kazuhiro Yoshiura, Gwanghee Han, Tomohisa Ishikawa, Asuka Koyama, Noriyuki Ogawa, Michio Maruta, Yuriko Ikeda, Takaaki Mori, Taku Yoshida, Mamoru Hashimoto, Manabu Ikeda
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 10, Iss 1, Pp 27-37 (2020)
Background/Aims: Age-related changes in impairments in activities of daily living (ADL) in older adults with very mild Alzheimer’s disease (vmAD) have been scarcely explored. We clarified the characteristics of ADL impairment and examined how ADL i
Externí odkaz:
https://doaj.org/article/70c02689672c461d9b9b5306343c3cc9
Autor:
Kenna Shirasuna, Gerald Koelsch, Cynthia Seidel-Dugan, Andres Salmeron, Philipp Steiner, William M Winston, Heather R Brodkin, Christopher J Nirschl, Sandra Abbott, Fumitaka Kinugasa, Shingo Sugahara, Makoto Ohori, Masahiro Takeuchi, Daniel J Hicklin, Taku Yoshida
Publikováno v:
Cancer Treatment and Research Communications, Vol 28, Iss , Pp 100433- (2021)
The T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) is a validated immune checkpoint protein expressed on memory CD4+T-cellls, Tregs, CD8+T-cell and natural killer (NK) cells. ASP8374 is a fully
Externí odkaz:
https://doaj.org/article/3f7206e212ff458fafde0fb42ac5fbbd
Autor:
Hideaki Shimizu, Takaaki Mori, Taku Yoshida, Ayumi Tachibana, Tomoki Ozaki, Yuta Yoshino, Shinichiro Ochi, Naomi Sonobe, Teruhisa Matsumoto, Kenjiro Komori, Jun‐ichi Iga, Toshiharu Ninomiya, Shu‐ichi Ueno, Manabu Ikeda
Publikováno v:
Psychogeriatrics. 22:631-641
The number of dementia patients is increasing worldwide, especially in Japan, which has the world's highest ageing population. The increase in the number of older people with dementia is a medical and socioeconomic problem that needs to be prevented,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ce46caedecbc453370e75e1151a541
https://doi.org/10.1111/psyg.12865
https://doi.org/10.1111/psyg.12865