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Akademický článek

Identification of novel glucocerebrosidase chaperones by unexpected skeletal rearrangement reaction.

Autor: Takeda K; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Watanabe T; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Smith JR; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Vesey D; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Tiberghien N; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Lewis S; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Powney B; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Schapira AHV; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Hoshikawa T; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom. Electronic address: t-hoshikawa@hhc.eisai.co.jp., Takle AK; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Nov 15; Vol. 96, pp. 129531. Date of Electronic Publication: 2023 Oct 20.

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Akademický článek

Advancing novel therapies for neurodegeneration through an innovative model for industry-academia collaborations: A decade of the Eisai-UCL experience.

Autor: Atkinson PJ; Eisai Ltd., EMEA Knowledge Centre, Mosquito Way, Hatfield, UK. Electronic address: peter_atkinson@eisai.net., Swami M; Eisai Ltd., EMEA Knowledge Centre, Mosquito Way, Hatfield, UK., Ridgway N; Translational Research Office, University College London, UCL Maple House, 149 Tottenham Court Road, London, UK., Roberts M; Eisai Ltd., EMEA Knowledge Centre, Mosquito Way, Hatfield, UK., Kinghorn J; Translational Research Office, University College London, UCL Maple House, 149 Tottenham Court Road, London, UK., Warner TT; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, 1 Wakefield Street, London, UK., Staddon JM; Eisai Ltd., EMEA Knowledge Centre, Mosquito Way, Hatfield, UK., Takle AK; Eisai Ltd., EMEA Knowledge Centre, Mosquito Way, Hatfield, UK.

Publikováno v: Drug discovery today [Drug Discov Today] 2023 Oct; Vol. 28 (10), pp. 103732. Date of Electronic Publication: 2023 Aug 02.

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Akademický článek

Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones.

Autor: Hoshikawa T; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom. Electronic address: t-hoshikawa@hhc.eisai.co.jp., Watanabe T; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Kotake M; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Tiberghien N; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Woo CK; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Lewis S; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Briston T; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Koglin M; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Staddon JM; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Powney B; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Schapira AHV; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Takle AK; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Feb 01; Vol. 81, pp. 129130. Date of Electronic Publication: 2023 Jan 12.

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Akademický článek

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Na v 1.7.

Autor: Wright ZVF; Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom., McCarthy S; Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom., Dickman R; Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom., Reyes FE; Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147, United States., Sanchez-Martinez S; Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147, United States., Cryar A; Institute of Structural and Molecular Biology, Division of Biosciences, University College London , Gower Street, London WC1E 6BT, United Kingdom.; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London , London WC1E 7HX, United Kingdom., Kilford I; European Knowledge Centre, Eisai Limited , Mosquito Way, Hatfield, Hertfordshire AL10 9SN, United Kingdom., Hall A; European Knowledge Centre, Eisai Limited , Mosquito Way, Hatfield, Hertfordshire AL10 9SN, United Kingdom., Takle AK; European Knowledge Centre, Eisai Limited , Mosquito Way, Hatfield, Hertfordshire AL10 9SN, United Kingdom., Topf M; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London , London WC1E 7HX, United Kingdom., Gonen T; Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147, United States., Thalassinos K; Institute of Structural and Molecular Biology, Division of Biosciences, University College London , Gower Street, London WC1E 6BT, United Kingdom.; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London , London WC1E 7HX, United Kingdom., Tabor AB; Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2017 Sep 20; Vol. 139 (37), pp. 13063-13075. Date of Electronic Publication: 2017 Sep 07.

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