Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Takeyuki Nagashima"'
Autor:
Hiroyuki Sayama, Diana Marcantonio, Takeyuki Nagashima, Masashi Shimazaki, Tsuyoshi Minematsu, Joshua F Apgar, John M. Burke, Lucia Wille, Yasuhisa Nagasaka, Daniel C. Kirouac
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 864-877 (2021)
Abstract KRAS is a small GTPase family protein that relays extracellular growth signals to cell nucleus. KRASG12C mutations lead to constitutive proliferation signaling and are prevalent across human cancers. ASP2453 is a novel, highly potent, and se
Externí odkaz:
https://doaj.org/article/307d52ab94554a9cbf4a9e35c1594f22
Autor:
Takeyuki Nagashima, Diana H. Marcantonio, Tsuyoshi Minematsu, Daniel C. Kirouac, Masashi Shimazaki, John M. Burke, Yasuhisa Nagasaka, Joshua F. Apgar, Hiroyuki Sayama, Lucia Wille
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 864-877 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
KRAS is a small GTPase family protein that relays extracellular growth signals to cell nucleus. KRAS G12C mutations lead to constitutive proliferation signaling and are prevalent across human cancers. ASP2453 is a novel, highly potent, and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4404b4285eefa28947f77b57ba1c5fa2
https://doi.org/10.1002/psp4.12661
https://doi.org/10.1002/psp4.12661
Autor:
Takeyuki Nagashima, Tomohiro Yoshinari, Yoshihiro Nishizono, Mamoru Tasaki, Kohei Inamura, Hiroki Ishioka, Atsushi Suzuki, Fumio Osaki, Yosuke Yamanaka, Masahiko Hayakawa
Publikováno v:
Cancer Research. 83:5735-5735
KRAS is one of the most frequently mutated oncogenes in various cancers. Among KRAS mutations, KRAS G12D is the most frequent driver mutation and is found in approximately 34% of patients with pancreatic ductal adenocarcinoma (PDAC), 12% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa9c07b82d57a34ff25ef9dc3c98969
https://doi.org/10.1158/1538-7445.am2023-5735
https://doi.org/10.1158/1538-7445.am2023-5735
Autor:
Takashi Shin, Takeyuki Nagashima, Tomohiro Yamada, Yuki Sawada, Kazuyuki Kuramoto, Naoki Ishibashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:77-90
Novel 3,5-dimethylpyridin-4(1H)-one scaffold compounds were synthesized and evaluated as AMP-activated protein kinase (AMPK) activators. Unlike direct AMPK activators, this series of compounds showed selective cell growth inhibitory activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a57805c806848115ccd10670ca42a7
https://doi.org/10.1248/cpb.c19-00800
https://doi.org/10.1248/cpb.c19-00800
Autor:
Tomoyoshi, Imaizumi, Michinori, Akaiwa, Tomoaki, Abe, Takahiro, Nigawara, Takanori, Koike, Yoshiki, Satake, Kazushi, Watanabe, Osamu, Kaneko, Yasushi, Amano, Kenichi, Mori, Yosuke, Yamanaka, Takeyuki, Nagashima, Masashi, Shimazaki, Kazuyuki, Kuramoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 71:116949
RAS protein plays a key role in cellular proliferation and differentiation. RAS gene mutation is a known driver of oncogenic alternation in human cancer. RAS inhibition is an effective therapeutic treatment for solid tumors, but RAS protein has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d7da162113fdb0136dd48b51690460
https://doi.org/10.1016/j.bmc.2022.116949
https://doi.org/10.1016/j.bmc.2022.116949
Autor:
Kei Ohnuki, Kazuyuki Kuramoto, Takeyuki Nagashima, Tomohiro Yamada, Yuki Sawada, Takashi Shin
Publikováno v:
Chemicalpharmaceutical bulletin. 68(5)
This study reports the synthesis and evaluation of novel indirect AMP-activated protein kinase (AMPK) activators. The series of compounds selectively inhibited cell growth in several human breast cancer cell lines by activating AMPK. We performed bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66ee82cfa11042b873b38894904493c
https://pubmed.ncbi.nlm.nih.gov/32378543
https://pubmed.ncbi.nlm.nih.gov/32378543
Autor:
Kazuyuki, Kuramoto, Yuki, Sawada, Naoki, Ishibashi, Tomohiro, Yamada, Takeyuki, Nagashima, Takashi, Shin
Publikováno v:
Chemicalpharmaceutical bulletin. 68(1)
Novel 3,5-dimethylpyridin-4(1H)-one scaffold compounds were synthesized and evaluated as AMP-activated protein kinase (AMPK) activators. Unlike direct AMPK activators, this series of compounds showed selective cell growth inhibitory activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f080792138aca396c041847fb20e681
https://pubmed.ncbi.nlm.nih.gov/31902903
https://pubmed.ncbi.nlm.nih.gov/31902903
Autor:
Kei Ohnuki, Hiroyoshi Yamada, Kazuyuki Kuramoto, Tomohiro Yamada, Hidenori Azami, Yuki Sawada, Takeyuki Nagashima, Takashi Shin
Publikováno v:
Bioorganicmedicinal chemistry. 28(5)
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a key role in maintaining cellular metabolism. AMP or adenosine diphosphate (ADP) levels rise during metabolic stress, such as during nutrient starvation, hypoxia and muscle contract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a037614490ec24a04e5c0c4abba0b908
https://pubmed.ncbi.nlm.nih.gov/32007387
https://pubmed.ncbi.nlm.nih.gov/32007387
Autor:
Akiyoshi Shimaya, Masayuki Shibasaki, Yasuharu Urano, Takeyuki Nagashima, Hirotsugu Tanaka, Teruhiko Shimokawa
Publikováno v:
European Journal of Pharmacology. 645:185-191
Recent evidence suggests that the forkhead transcription factor Foxo1 plays an important role in the regulation of glucose and triglyceride metabolism at the gene transcription level for glucose-6 phosphatase (G6Pase), phosphoenolpyruvate carboxykina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298aca6e08c296a4ce1b30dc7a9944c2
https://doi.org/10.1016/j.ejphar.2010.07.018
https://doi.org/10.1016/j.ejphar.2010.07.018
Autor:
Mino Hasegawa, Osamu Okitsu, Takeshi Mori, Yoshiki Katayama, Akiko Tsuchida, Takeyuki Nagashima, Ryosuke Kurihara, Yusuke Inoue, Takuro Niidome
Publikováno v:
Journal of Controlled Release. 126:59-66
RNA interference (RNAi) is a valuable tool for the validation of gene identification and functional genomics. Previously, it was reported that 6th generation dendritic poly(L-lysine) (KG6) transfected DNA into several cultivated cell lines with high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69099b453716892f262dc7d49faff104
https://doi.org/10.1016/j.jconrel.2007.10.022
https://doi.org/10.1016/j.jconrel.2007.10.022