An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.

Autor: Furlanis E; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; These authors contributed equally., Dai M; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; These authors contributed equally., Leyva Garcia B; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; These authors contributed equally., Vergara J; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pereira A; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pelkey K; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Tran T; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gorissen BL; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vlachos A; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Hairston A; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA., Huang S; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA., Dwivedi D; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Du S; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wills S; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., McMahon J; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lee AT; Department of Neurological Surgery, University of California San Francisco, San Francisco, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, USA., Chang EF; Department of Neurological Surgery, University of California San Francisco, San Francisco, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, USA., Razzaq T; Tibbling Technologies, Redmond, WA, USA., Qazi A; Tibbling Technologies, Redmond, WA, USA., Vargish G; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Yuan X; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Caccavano A; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Hunt S; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Chittajallu R; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., McLean N; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Hewit L; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Paranzino E; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Rice H; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Cummins AC; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Plotnikova A; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Mohanty A; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Tangen AC; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Shin JH; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Azadi R; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Eldridge MAG; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Alvarez VA; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Averbeck BB; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA., Alyahyay M; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia., Reyes Vallejo T; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia., Soheib M; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia., Vattino LG; Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary Boston, USA.; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School Boston, USA., MacGregor CP; Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary Boston, USA.; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School Boston, USA., Banks E; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA., Olah VJ; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA., Naskar S; Unit of Functional Neural Circuit, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA., Hill S; Department of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Liebergall S; Department of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Badiani R; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hyde L; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Xu Q; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia.; Genomics & Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE., Allaway KC; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Goldberg EM; Department of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Nowakowski TJ; Department of Neurological Surgery, University of California San Francisco, San Francisco, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, USA.; Department of Anatomy, University of California, San Francisco (UCSF), San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA., Lee S; Unit of Functional Neural Circuit, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA., Takesian AE; Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary Boston, USA.; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School Boston, USA., Ibrahim LA; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia., Iqbal A; Tibbling Technologies, Redmond, WA, USA., McBain CJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA., Dimidschstein J; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Fishell G; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wang Y; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 06. Date of Electronic Publication: 2024 Sep 06.

Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression.

Autor: Zhu Y; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. yiwenzhu@mail.harvard.edu.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. yiwenzhu@mail.harvard.edu., Wang MJ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Crawford KM; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Ramírez-Tapia JC; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Lussier AA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Davis KA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., de Leeuw C; Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Takesian AE; Eaton-Peabody Laboratories, Massachusetts Eye & Ear and Department of Otorhinolaryngology and Head/Neck Surgery, Harvard Medical School, Boston, MA, USA., Hensch TK; Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Smoller JW; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dunn EC; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. edunn2@mgh.harvard.edu.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. edunn2@mgh.harvard.edu.; Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA. edunn2@mgh.harvard.edu.; Harvard Center on the Developing Child, Cambridge, MA, USA. edunn2@mgh.harvard.edu.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2022 Jan; Vol. 47 (2), pp. 497-506. Date of Electronic Publication: 2021 Oct 23.

All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1.

Autor: Fan LZ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Kheifets S; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Böhm UL; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Wu H; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Piatkevich KD; Media Lab and McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Xie ME; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Parot V; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Ha Y; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Evans KE; Harvard Medical School, Boston, MA, USA., Boyden ES; Media Lab and McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Takesian AE; Harvard Medical School, Boston, MA, USA; Massachusetts Eye and Ear Infirmary, Boston, MA, USA., Cohen AE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA; Department of Physics, Harvard University, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: cohen@chemistry.harvard.edu.

Publikováno v: Cell [Cell] 2020 Feb 06; Vol. 180 (3), pp. 521-535.e18. Date of Electronic Publication: 2020 Jan 23.

Publisher Correction: Inhibitory circuit gating of auditory critical-period plasticity.

Autor: Takesian AE; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA., Bogart LJ; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA., Lichtman JW; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA., Hensch TK; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA. hensch@mcb.harvard.edu.; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA. hensch@mcb.harvard.edu.

Publikováno v: Nature neuroscience [Nat Neurosci] 2018 Oct; Vol. 21 (10), pp. 1495.

Inhibitory circuit gating of auditory critical-period plasticity.

Autor: Takesian AE; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA., Bogart LJ; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA., Lichtman JW; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA., Hensch TK; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA. hensch@mcb.harvard.edu.; Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA. hensch@mcb.harvard.edu.

Publikováno v: Nature neuroscience [Nat Neurosci] 2018 Feb; Vol. 21 (2), pp. 218-227. Date of Electronic Publication: 2018 Jan 22.