Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Takeshi Takarada"'
Autor:
Tomoka Takao, Masato Sato, Yuki Fujisawa, Eriko Toyoda, Daisuke Yamada, Yukio Hitsumoto, Eiji Nakata, Toshifumi Ozaki, Takeshi Takarada
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-6 (2023)
Abstract Background Cell sheet fabrication for articular cartilage regenerative medicine necessitates a large number of chondrocytes of consistent quality as a cell source. Previously, we have developed human-induced pluripotent stem cell (iPSC)-deri
Externí odkaz:
https://doaj.org/article/578115cda7d94db2af974dd3f4b234ac
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-8 (2022)
Abstract Tendon regeneration is difficult because detailed knowledge about tendon progenitor cells (TPCs), which produce tenocytes to repair tendon tissue, has not been revealed. Mohawk homeobox (MKX) is a marker of TPCs or tenocytes, but a human plu
Externí odkaz:
https://doaj.org/article/a0c2ec9dbddf43d0a8c8c5c48244b914
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101786- (2022)
Summary: Here, we present a protocol for the selective differentiation of human pluripotent stem cells mimicking human developmental processes into expandable PRRX1+ limb-bud mesenchymal (ExpLBM) cells. This approach enables expansion through serial
Externí odkaz:
https://doaj.org/article/0156ab32117e48fe97a96ba34bee9a2b
Autor:
Somang Lee-Thacker, Hayce Jeon, Yohan Choi, Ichiro Taniuchi, Takeshi Takarada, Yukio Yoneda, CheMyong Ko, Misung Jo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Core Binding Factors (CBFs) are a small group of heterodimeric transcription factor complexes composed of DNA binding proteins, RUNXs, and a non-DNA binding protein, CBFB. The LH surge increases the expression of Runx1 and Runx2 in ovulatory
Externí odkaz:
https://doaj.org/article/3d5f1b8574d942ac9a1a967e2817153e
Autor:
Jung-Min Kim, Yeon-Suk Yang, Kwang Hwan Park, Xianpeng Ge, Ren Xu, Na Li, Minkyung Song, Hyunho Chun, Seoyeon Bok, Julia F. Charles, Odile Filhol-Cochet, Brigitte Boldyreff, Teresa Dinter, Paul B. Yu, Ning Kon, Wei Gu, Takeshi Takarada, Matthew B. Greenblatt, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their sub
Externí odkaz:
https://doaj.org/article/d66c7cf3ddb9472bb8083540eab23003
Autor:
Ryoji Joko, Daisuke Yamada, Masahiro Nakamura, Aki Yoshida, Shota Takihira, Tomoka Takao, Ming Lu, Kohei Sato, Tatsuo Ito, Toshiyuki Kunisada, Eiji Nakata, Toshifumi Ozaki, Takeshi Takarada
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100960- (2021)
Paired related homeobox 1 (PRRX1) is a marker of limb bud mesenchymal cells, and deficiency of p53 or Rb in Prrx1-positive cells induces osteosarcoma in several mouse models. However, the regulatory roles of PRRX1 in human osteosarcoma have not been
Externí odkaz:
https://doaj.org/article/1971cd31bce84d06be2c73ad535dfdeb
Autor:
Lifan Liao, Shanxing Zhang, Jianhong Gu, Takeshi Takarada, Yukio Yoneda, Jian Huang, Lan Zhao, Chun-do Oh, Jun Li, Baoli Wang, Meiqing Wang, Di Chen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Runx2 may play an important role in development of osteoarthritis (OA). However, the specific role of Runx2 in articular chondrocyte function and in OA development in adult mice has not been fully defined. In this study, we performed the des
Externí odkaz:
https://doaj.org/article/599c91f9147140b096f48826257dbaab
Autor:
Takeshi Takarada, Noritaka Nakamichi, Ryota Nakazato, Takami Kakuda, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Nobuyuki Kuramoto, Eiichi Hinoi, Yukio Yoneda
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 89-95 (2016)
We have shown marked promotion of both proliferation and neuronal differentiation in pluripotent P19 cells exposed to the green tea amino acid theanine, which is a good substrate for SLC38A1 responsible for glutamine transport. In this study, we eval
Externí odkaz:
https://doaj.org/article/31db8f1b66054700b513d3e6fe05e350
Autor:
Takeshi Takarada, Noritaka Nakamichi, Takami Kakuda, Ryota Nakazato, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Eiichi Hinoi, Yukio Yoneda
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 292-297 (2015)
Posttraumatic stress disorder is a long-lasting psychiatric disease with the consequence of hippocampal atrophy in humans exposed to severe fatal stress. We demonstrated a positive correlation between the transient decline of 5-bromo-2′-deoxyuridin
Externí odkaz:
https://doaj.org/article/4b6a8ef0a7094f46af4753039e9a2f5a
Autor:
Nguyen Quynh Le, Nguyen Thanh Binh, Takeshi Takarada, Mika Takarada-Iemata, Eiichi Hinoi, Yukio Yoneda
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 4, Pp 318-326 (2013)
Pre-chondrocytes undergo cellular differentiation stages during chondrogenesis under the influence by different transcription factors such as sry-type high mobility group box-9 (Sox9) and runt-related transcription factor-2 (Runx2). We have shown upr
Externí odkaz:
https://doaj.org/article/551b84be6db74a11964a82c33d2bc808