Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Takeshi Shiiki"'
1
Synthesis and structure-activity relationship of 4-alkoxy-thieno[2,3-b]pyridine derivatives as potent alkaline phosphatase enhancers for osteoporosis treatment
Autor: Tomonori Kunikata, Akira Nakao, Takeshi Shiiki, Satoru Naito, Toshihiro Kiho, Keiji Saito, Tsuyoshi Shinozuka, Yoko Nagai
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:1769-1773
The synthesis and structure-activity relationships of a novel series of 3-aminothieno[2,3-b]pyridine-2-carboxamides were explored. Our efforts were focused on modifying the C-4 substituent of the thienopyridine ring to develop orally available bone a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85370c94ad450ebdc70fd3d1f5f993f
https://doi.org/10.1016/j.bmcl.2019.05.014
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2
Pharmacokinetic and Pharmacodynamic Profiles of Glyco-Modified Atrial Natriuretic Peptide Derivatives Synthesized Using Chemo-enzymatic Synthesis Approaches
Autor: Hiroyuki Chaya, Takahiro Nagayama, Makoto Yoshida, Yukiko Sekiguchi, Jun Hasegawa, Nakamura Kensuke, Takeshi Shiiki, Masako Soma, Shohei Oishi, Takahiro Yamaguchi, Takeshi Honda, Yutaka Mori, Ryuki Miyauchi, Iwamoto Mitsuhiro
Publikováno v: Bioconjugate chemistry. 29(8)
Atrial natriuretic peptide (ANP) exerts beneficial pharmacological effects in the treatment of various cardiovascular disorders, such as acute congestive heart failure (ADHF). However, the clinical use of ANP is limited to the continuous intravenous
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ded42d5421c78b4903f17c00f6d28af
https://pubmed.ncbi.nlm.nih.gov/30107743
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3
Brain Insulin Impairs Amyloid-β(1-40) Clearance from the Brain
Autor: Masanori Tachikawa, Sumio Ohtsuki, Kenji Nishimura, Ken Ichi Hosoya, Tetsuya Terasaki, Takeshi Shiiki, Hideo Naganuma, Atsushi Kurihara
Publikováno v: The Journal of Neuroscience. 24:9632-9637
Cerebral amyloid-β peptide (Aβ) clearance plays a key role in determining the brain level of Aβ; however, its mechanism remains unclear. In this study, we investigated cerebral Aβ clearance across the blood-brain barrier (BBB) by using the Brain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a03b0ba095559b4eb09b930cd8e24e1
https://doi.org/10.1523/jneurosci.2236-04.2004
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5
Discovery of potent and orally active tricyclic-based FBPase inhibitors
Autor: Mizuki Takahashi, Jun Tanaka, Taishi Yoshida, Takahide Nishi, Takahiro Yamane, Osamu Kanno, Akira Okuno, Tomoharu Tsukada, Takeshi Shiiki
Publikováno v: Bioorganicmedicinal chemistry. 18(14)
With the aim of exploring the effect of tricyclic-based FBPase inhibitors in cells and in vivo, a series of prodrugs of tricyclic phosphonates was designed and synthesized. Introducing prodrug moieties into tricyclic-based phosphonates led to the dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c45c7b29552b9f1802b68964359368
https://pubmed.ncbi.nlm.nih.gov/20542703
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6
A prodrug approach towards the development of tricyclic-based FBPase inhibitors
Autor: Takeshi Shiiki, Toshiyuki Takagi, Jun Tanaka, Tomoharu Tsukada, Kazuhiko Tamaki, Akira Okuno, Mizuki Takahashi, Takahide Nishi, Taishi Yoshida
Publikováno v: Bioorganicmedicinal chemistry letters. 20(9)
For the purpose of reducing the strong CYP3A4 inhibitory potency of diamide prodrug 4, cyclic prodrugs of tricyclic-based FBPase inhibitors were synthesized. Extensive SAR studies led to the discovery of pyridine-containing cyclic prodrug 20, which s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd6c5f700a81798215294e9470f4c8
https://pubmed.ncbi.nlm.nih.gov/20359891
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