Výsledky vyhledávání - "Takeshi Shida"

Discovery of a novel ATP-competitive MEK inhibitor DS03090629 that overcomes resistance conferred by BRAF overexpression in BRAF-mutated melanoma

Autor: Kohei Takano, Yoichi Munehira, Mana Hatanaka, Ryo Murakami, Yoshihiro Shibata, Takeshi Shida, Kosuke Takeuchi, Sho Takechi, Toshiki Tabata, Takashi Shimada, Shuhei Kishikawa, Yumi Matsui, Osamu Ubukata, Takahiko Seki, Yasuyuki Kaneta

Publikováno v: Molecular cancer therapeutics.

Patients with melanoma with activating BRAF mutations (BRAF V600E/K) initially respond to combination therapy of BRAF and MEK inhibitors. However, their clinical efficacy is limited by acquired resistance, in some cases driven by amplification of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6040d68a8b817ab0dfc5fb7e8344a54
https://pubmed.ncbi.nlm.nih.gov/36622773

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Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure

Autor: Narihiro Toda, Takeshi Shida, Rieko Takano, Takahiro Katagiri, Masakazu Hirouchi, Manabu Abe, Kaori Soma, Yasuhiro Nakagami, Mami Yamazaki

Publikováno v: Bioorganicmedicinal chemistry letters. 59

Motilin is a 22-amino-acid gastrointestinal (GI) hormone and is involved in the regulation of GI motility through binding to GPR38, the motilin receptor which is expressed on smooth muscle cells in the GI tract. Therefore, GPR38 agonists are expected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a43fbc0c52ec8ac7aaafe2d05435464
https://pubmed.ncbi.nlm.nih.gov/35051575

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Synthesis and stereochemical confirmation of the HI/JK ring system of prymnesins, potent hemolytic and ichthyotoxic glycoside toxins isolated from the red tide alga

Autor: Takeshi Shida, Kazuo Tachibana, Makoto Sasaki

Publikováno v: Tetrahedron Letters. 42:5725-5728

Stereocontrolled synthesis of the HI/JK ring model of the prymnesins, glyosidic toxins isolated from the red tide phytoflagellate Prymnesium parvum , is described. Comparison of its 1 H and 13 C NMR data with those of the natural toxins established t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edd10561b089e789c4ea5a57b341044e
https://doi.org/10.1016/s0040-4039(01)01067-x

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Dynamic NMR study on the trans-fused eight-membered ether ring model representing G ring of brevetoxin A

Autor: Takeshi Shida, Kazuo Tachibana

Publikováno v: Tetrahedron Letters. 46:1855-1857

Conformational analysis of the trans-fused eight-membered ether ring model (2) representing G ring of brevetoxin A (1) was carried out by dynamic NMR study in combination with molecular mechanics calculations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::675138e41cefb7f909a7e49bc8abe165
https://doi.org/10.1016/j.tetlet.2005.01.100

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Lissoclibadins 1—3, Three New Polysulfur Alkaloids, from the Ascidian Lissoclinum cf. badium

Autor: Hiroshi Nagai, Yuri Mishima, Kazuo Tachibana, Remy E. P. Mangindaan, Hongwei Liu, Takeshi Shida, Teruaki Nishikawa, Hisayoshi Kobayashi, Takeshi Fujiwara, Michio Namikoshi

Publikováno v: ChemInform. 36

Three new polysulfur alkaloids, lissoclibadins 1 ( 1 )–3 ( 3 ), were isolated from the ascidian Lissoclinum sp. (cf. L. badium Monniot, F. and Monniot, C., 1996). The structures of 1 – 3 were assigned on the basis of their spectral data, and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ed003038d82adf083f3608678f285e
https://doi.org/10.1002/chin.200551181

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Lissoclibadin 1, a Novel Trimeric Sulfur-Bridged Dopamine Derivative, from the Tropical Ascidian Lissoclinum cf. badium

Autor: Takeshi Fujiwara, Michio Namikoshi, Hiroshi Nagai, Kazuo Tachibana, Hongwei Liu, Teruaki Nishikawa, Hisayoshi Kobayashi, Silvester B. Pratasik, Takeshi Shida

Publikováno v: ChemInform. 36

A novel tribenzotetrathiepin alkaloid, named lissoclibadin 1 ( 1 ), has been isolated from the ascidian Lissoclinum sp. (cf. L . badium Monniot and Monniot, 1996). The gross structure was assigned on the basis of the spectral data, and one of two pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b479c45f835dc0826a411824ffe0f726
https://doi.org/10.1002/chin.200501180

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Synthesis of the CDE/FG ring models of prymnesins: reassignment of the relative configuration of the E/F ring juncture

Autor: Makoto Ebine, Takeshi Yasumoto, Makoto Sasaki, Hiroyuki Takakura, Hiroyuki Takagi, Tomoji Igarashi, Yasukatsu Oshima, Takeshi Shida, Masayuki Satake

Publikováno v: Organic letters. 6(9)

[structure: see text] Synthesis of two diastereomeric models (3a and 3b) corresponding to the CDE/FG ring of prymnesins, polycyclic ether toxins isolated from the red tide phytoflagellate Prymnesium parvum, is described. Comparison of the (1)H and (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19e3129c89fdd4ee48a56d5b228a76a
https://pubmed.ncbi.nlm.nih.gov/15101777

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