Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Takeshi Sakaba"'
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
To understand how neurons and neural circuits function during behaviors, it is essential to record neuronal activity in the brain in vivo. Among the various technologies developed for recording neuronal activity, molecular tools that induce gene expr
Externí odkaz:
https://doaj.org/article/b44594e72e8a40f9b258aac5542ae0ce
Publikováno v:
eLife, Vol 12 (2024)
Synaptic vesicles dock and fuse at the presynaptic active zone (AZ), the specialized site for transmitter release. AZ proteins play multiple roles such as recruitment of Ca2+ channels as well as synaptic vesicle docking, priming, and fusion. However,
Externí odkaz:
https://doaj.org/article/1c15adef3ec94ee5987a501815b971a3
Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Presynaptic plasticity is an activity-dependent change in the neurotransmitter release and plays a key role in dynamic modulation of synaptic strength. Particularly, presynaptic potentiation mediated by cyclic adenosine monophosphate (cAMP) is widely
Externí odkaz:
https://doaj.org/article/09320e70de334da98f9cc92b1cbc54c6
Autor:
Maria Jäpel, Fabian Gerth, Takeshi Sakaba, Jelena Bacetic, Lijun Yao, Seong-Joo Koo, Tanja Maritzen, Christian Freund, Volker Haucke
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 409-420.e6 (2020)
Summary: The rapid replenishment of release-ready synaptic vesicles (SVs) at a limiting number of presynaptic release sites is required to sustain high-frequency neurotransmission in CNS neurons. Failure to clear release sites from previously exocyto
Externí odkaz:
https://doaj.org/article/6bb6940910be4bb98a685cfb307b97e0
Autor:
Shin-ya Kawaguchi, Takeshi Sakaba
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3338-3345 (2017)
Summary: The small size of presynaptic structures and their rapid function have obscured the mechanisms underlying neurotransmission and plasticity. To dissect the function of conventional small presynaptic boutons, we performed direct recording usin
Externí odkaz:
https://doaj.org/article/6988748eef40453eb08f0c05e73a5371
Autor:
Yuji Okamoto, Noa Lipstein, Yunfeng Hua, Kun-Han Lin, Nils Brose, Takeshi Sakaba, Mitsuharu Midorikawa
Publikováno v:
eLife, Vol 5 (2016)
Neurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential. We combined capacitance measurements and pH-i
Externí odkaz:
https://doaj.org/article/3d9265b59f9e418f81c8e2254a3c04a5
Publikováno v:
eLife; 2/8/2024, p1-19, 19p
Autor:
Ryota Fukaya, Himawari Hirai, Hirokazu Sakamoto, Yuki Hashimotodani, Kenzo Hirose, Takeshi Sakaba
Presynaptic long-term potentiation (LTP) is thought to play an important role in learning and memory. However, the underlying mechanism remains elusive because of the difficulty of direct recording during LTP. Hippocampal mossy fiber synapses exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf2e5d277c5740d226ef5e56a4c5bf0
https://refubium.fu-berlin.de/handle/fub188/38883
https://refubium.fu-berlin.de/handle/fub188/38883
Publikováno v:
Exocytosis: From Molecules to Cells ISBN: 9780750337717
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4665dd560d734ebf2a13a70eea7cd379
https://doi.org/10.1088/978-0-7503-3771-7ch13
https://doi.org/10.1088/978-0-7503-3771-7ch13
Synaptic vesicles dock and fuse at the presynaptic active zone (AZ), the specialized site for transmitter release. AZ proteins play multiple roles such as recruitment of Ca2+ channels as well as synaptic vesicle docking, priming and fusion. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b733838536ad3d937fedfc5faf79f5d0
https://doi.org/10.1101/2022.08.29.505728
https://doi.org/10.1101/2022.08.29.505728