Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Takeshi Otsubo"'
Autor:
Takeshi Otsubo, Tadashi Okamura, Teruki Hagiwara, Yukihito Ishizaka, Taeko Dohi, Yuki I Kawamura
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116072 (2015)
Long interspersed element-1 (L1) is a transposable element that can move within the genome, potentially leading to genome diversity and modified gene function. Although L1 activity in somatic cells is normally suppressed through DNA methylation, some
Externí odkaz:
https://doaj.org/article/15b8b3e720fd4b50aaa2b7d4ca1e3e45
Autor:
Tomoyuki Oshio, Rei Kawashima, Yuki I Kawamura, Teruki Hagiwara, Noriko Mizutani, Toshihiko Okada, Takeshi Otsubo, Kyoko Inagaki-Ohara, Akihiro Matsukawa, Tatsuya Haga, Shigeru Kakuta, Yoichiro Iwakura, Seijiro Hosokawa, Taeko Dohi
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94445 (2014)
Chemokine (C-C motif) receptor 8 (CCR8), the chemokine receptor for chemokine (C-C motif) ligand 1 (CCL1), is expressed in T-helper type-2 lymphocytes and peritoneal macrophages (PMφ) and is involved in various pathological conditions, including per
Externí odkaz:
https://doaj.org/article/66da9cc3a05a4116bd139b7990b85f75
Autor:
Takeshi Otsubo, Yoshimitsu Akiyama, Yutaka Hashimoto, Shu Shimada, Kentaro Goto, Yasuhito Yuasa
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16617 (2011)
BACKGROUND: SRY (sex-determining region Y)-box 2 (SOX2) is a crucial transcription factor for the maintenance of embryonic stem cell pluripotency and the determination of cell fate. Previously, we demonstrated that SOX2 plays important roles in growt
Externí odkaz:
https://doaj.org/article/b0a37bf4940a485a9a3217a563d9a69c
Autor:
Masahira Hattori, Takeshi Otsubo, Yuki I. Kawamura, Satoshi Yamashita, Kei Iida, Kazuhiko Yamada, Toru Igari, Taeko Dohi, Koro Nishikata, Kenshiro Oshima, Tetsuro Toyoda, Kyoko Nohara, Teruki Hagiwara
Publikováno v:
Oncotarget
Esophageal squamous cell carcinoma (ESCC) is associated with the accumulation of genetic and epigenetic changes in the background mucosa. Dysregulated DNA methylation is known to lead to the inactivation of tumor suppressor genes and the activation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50cc7db8dc03b8b0034123e3b0c2db2
https://doi.org/10.18632/oncotarget.21375
https://doi.org/10.18632/oncotarget.21375
Autor:
John R. Weis, Harumi Suzuki, Masayuki Kitajima, Kenshiro Oshima, Takeshi Otsubo, Taeko Dohi, Yuki I. Kawamura, Toshiyuki Takai, Ryunosuke Muro, Masahira Hattori, Takaho A. Endo, Hiroyo Oda, Tetsuro Toyoda, Yoichi Shinkai, Shoichi Takikita
Publikováno v:
The Journal of Immunology. 197:2269-2279
ESET/SETDB1, one of the major histone methyltransferases, catalyzes histone 3 lysine 9 (H3K9) trimethylation. ESET is critical for suppressing expression of retroviral elements in embryonic stem cells; however, its role in the immune system is not kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a88d3985164b6e0d82afce63aae709d
https://doi.org/10.4049/jimmunol.1502486
https://doi.org/10.4049/jimmunol.1502486
Autor:
Chihaya Hinohara, Teruki Hagiwara, Yuki I. Kawamura, Oki Miyake, Toshio Shimizu, Miwa Tamura-Nakano, Takuhito Sezaki, Takeshi Otsubo, Taeko Dohi, Kazuhiko Yamada
Publikováno v:
Cancer Medicine
Periplakin (PPL), a member of the plakin family of proteins that localizes to desmosomes and intermediate filaments, is downregulated in human esophageal squamous cell carcinoma (ESCC). Little is known, however, about the molecular mechanism underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a12f9082cdee5a1ab8d44542d8e5f1e
http://europepmc.org/articles/PMC4380967
http://europepmc.org/articles/PMC4380967
Autor:
Yuki I. Kawamura, Eiko Kobayashi, Toshihiko Okada, Kazuhide Higuchi, Teruki Hagiwara, Taeko Dohi, Takuya Inoue, Takeshi Otsubo, Fumika Inazuka, Shinji Fukuda
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
Fasting-refeeding in mice induces transient hyperproliferation of colonic epithelial cells, which is dependent on the lactate produced as a metabolite of commensal bacteria. We attempted to manipulate colonic epithelial cell turnover with intermitten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b55fd757ff0ebc681accac58bf0c21
https://pubmed.ncbi.nlm.nih.gov/28955126
https://pubmed.ncbi.nlm.nih.gov/28955126
Publikováno v:
Cancer Research. 79:4078-4078
Toll-like receptors (TLRs) are a family of pattern-recognition receptors (PRR) that recognize pathogen-associated molecular patterns (PAMPs). TLR7 is mainly expressed in plasmacytoid dendritic cells (pDCs) and recognizes virus derived single-stranded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c58181d996dd6a023feba1ee659581c9
https://doi.org/10.1158/1538-7445.am2019-4078
https://doi.org/10.1158/1538-7445.am2019-4078
Autor:
Masashi Goto, Yosuke Ota, Yuko Hirose, Erina Koga-Yamakawa, Masashi Murata, Takeshi Otsubo, Yasushi Matsuki, Junya Koroki
Publikováno v:
Cancer Research. 78:4726-4726
Toll-like receptors (TLRs) are a family of pattern-recognition receptors (PRR) that recognize pathogen-associated molecular patterns (PAMPs). TLR7 is mainly expressed in plasmacytoid dendritic cells (pDCs) and recognizes virus derived single-stranded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f120be680debbdbb920aa12c558a3bf4
https://doi.org/10.1158/1538-7445.am2018-4726
https://doi.org/10.1158/1538-7445.am2018-4726
Publikováno v:
Carcinogenesis. 31:777-784
Aberrant expression of microRNA (miRNA) has been reported in various cancers. To clarify the role of miRNA in gastric carcinogenesis, we performed miRNA microarray analysis and investigated expression changes of miRNAs in a 5-aza-2'-deoxycytidine (5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be51672ebd64fbb8c197dcb63baba37
https://doi.org/10.1093/carcin/bgq013
https://doi.org/10.1093/carcin/bgq013