Zobrazeno 1 - 10
of 600
pro vyhledávání: '"Takeshi Noda"'
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT The hyaluronic acid capsule is crucial in protecting group A Streptococcus (GAS) against phagocytic killing. However, there have been reported outbreaks caused by capsule-deficient GAS strains, and the mechanisms underlying their evasion of
Externí odkaz:
https://doaj.org/article/7ac193490b7f429aba914968df3f0194
Autor:
Ryo Niwa, Kouji Sakai, Mandy Siu Yu Lung, Tomoko Matsumoto, Ryuta Mikawa, Shotaro Maehana, Masato Suzuki, Yuki Yamamoto, Thomas L. Maurissen, Ai Hirabayashi, Takeshi Noda, Makoto Kubo, Shimpei Gotoh, Knut Woltjen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/1900e217806e4b18ac7ee70eb831f2c7
Autor:
Kanako Tokuda, Shiou-Ling Lu, Zidi Zhang, Yumiko Kato, Siyu Chen, Kazuya Noda, Katsutoshi Hirose, Yu Usami, Narikazu Uzawa, Shinya Murakami, Satoru Toyosawa, Mitsunori Fukuda, Ge-Hong Sun-Wada, Yoh Wada, Takeshi Noda
Publikováno v:
Cell Structure and Function, Vol 48, Iss 2, Pp 223-239 (2023)
Osteoclasts play a crucial role in bone homeostasis by forming resorption pits on bone surfaces, resulting in bone resorption. The osteoclast expression of Rab38 protein is highly induced during differentiation from macrophages. Here we generated mic
Externí odkaz:
https://doaj.org/article/e7d62b5bd39e4e2782739301d81a6565
Autor:
Dohyun Im, Jun-ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, So Iwata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Histamine is a biogenic amine that participates in allergic and inflammatory processes by stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic target for chronic inflammatory diseases such as asthma and
Externí odkaz:
https://doaj.org/article/aecb7ce92dad48079fb1d6b2c25e5659
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113599- (2024)
Summary: Target of rapamycin complex 1 (TORC1) is a master regulator that monitors the availability of various amino acids to promote cell growth in Saccharomyces cerevisiae. It is activated via two distinct upstream pathways: the Gtr pathway, which
Externí odkaz:
https://doaj.org/article/2741d614525f48fc8212d539df2612fe
Autor:
Ryo Niwa, Kouji Sakai, Mandy Siu Yu Lung, Tomoko Matsumoto, Ryuta Mikawa, Shotaro Maehana, Masato Suzuki, Yuki Yamamoto, Thomas L. Maurissen, Ai Hirabayashi, Takeshi Noda, Makoto Kubo, Shimpei Gotoh, Knut Woltjen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, continues to spread around the world with serious cases and deaths. It has also been suggested that different genetic variants in the human genome affect b
Externí odkaz:
https://doaj.org/article/848a17b47661450f8d9a4795aaba1afe
Autor:
Shiou-Ling Lu, Takeshi Noda
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 555-558 (2022)
Xenophagy is an intracellular defense mechanism against invading pathogens. Streptococcus pyogenes (group A Streptococcus, GAS) is efficiently eliminated by this process in epithelial cells. However, we previously reported that the efficacy of xenoph
Externí odkaz:
https://doaj.org/article/642dcab9f8944599a3dd6f3aca47d4b7
Autor:
Zhikuan Zhang, Norimichi Nomura, Yukiko Muramoto, Toru Ekimoto, Tomoko Uemura, Kehong Liu, Moeko Yui, Nozomu Kono, Junken Aoki, Mitsunori Ikeguchi, Takeshi Noda, So Iwata, Umeharu Ohto, Toshiyuki Shimizu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
M protein plays essential roles in virus assembly and morphogenesis. Here, authors reveal two cryo-EM structures of M protein from SARS-CoV-2 that suggest conformational dynamics of M protein and its role in virus assembly.
Externí odkaz:
https://doaj.org/article/a5db8836d0a44eb0879660163e86a76f
Autor:
Hajime Shinoda, Tatsuya Iida, Asami Makino, Mami Yoshimura, Junichiro Ishikawa, Jun Ando, Kazue Murai, Katsumi Sugiyama, Yukiko Muramoto, Masahiro Nakano, Kotaro Kiga, Longzhu Cui, Osamu Nureki, Hiroaki Takeuchi, Takeshi Noda, Hiroshi Nishimasu, Rikiya Watanabe
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
An automated amplification-free digital RNA detection platform using CRISPR-Cas13a and magnetic bead technology implemented in a microchamber device demonstrates sensitive SARS-CoV-2 genomic RNA detection and variant discrimination.
Externí odkaz:
https://doaj.org/article/923ad554159546cdac4a486c9fc8e071
Autor:
Emi Sano, Tatsuya Suzuki, Rina Hashimoto, Yumi Itoh, Ayaka Sakamoto, Yusuke Sakai, Akatsuki Saito, Daisuke Okuzaki, Daisuke Motooka, Yukiko Muramoto, Takeshi Noda, Tomohiko Takasaki, Jun-Ichi Sakuragi, Shohei Minami, Takeshi Kobayashi, Takuya Yamamoto, Yasufumi Matsumura, Miki Nagao, Toru Okamoto, Kazuo Takayama
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Bronchial organoids (BO) and BO-derived air-liquid interface models (BO-ALI) are used to model SARS-CoV-2 infection of human bronchial epithelial cells, reporting that ciliated cells were permissive to the virus, unlike basal cells.
Externí odkaz:
https://doaj.org/article/9cc2cd2c28c541b5a28dd5c6e275c374