Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Takeshi Niki"'
Publikováno v:
Stem Cell Research, Vol 34, Iss , Pp - (2019)
Angelman syndrome is a rare neurodevelopmental disorder caused by the loss of function of the maternally expressed E3 ubiquitin ligase UBE3A. We established human induced pluripotent stem cells (iPSCs) from an Angelman syndrome patient with the delet
Externí odkaz:
https://doaj.org/article/dea2811a24c040aea310d7eb7d464963
Autor:
Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M.M. Iguchi-Ariga, Hiroyoshi Ariga
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 305-310 (2015)
Parkinson's disease (PD) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. Oxidative stress is one of the causes of PD. Since symptomatic PD therapies are used, identification of com
Externí odkaz:
https://doaj.org/article/1476a834b4384783a409ac145982a2ad
Autor:
Shiori Yamaguchi, Takuya Yamane, Kazuko Takahashi-Niki, Izumi Kato, Takeshi Niki, Matthew S Goldberg, Jie Shen, Kenji Ishimoto, Takefumi Doi, Sanae M M Iguchi-Ariga, Hiroyoshi Ariga
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38144 (2012)
DJ-1 is a novel oncogene and also causative gene for familial Parkinson's disease park7. DJ-1 has multiple functions that include transcriptional regulation, anti-oxidative reaction and chaperone and mitochondrial regulation. For transcriptional regu
Externí odkaz:
https://doaj.org/article/85540d3ab11747a0bc6b1f3164b38c29
Autor:
Makoto Fushimi, Yoshiteru Nishimura, Takeshi Niki, Tadashi Hidaka, Yoshinobu Kawahara, Haruhisa Inoue, Takeshi Hioki, Takagi Terufumi, Keiko Imamura, Satoru Hayashi, Mi Ho Giga, Yoshikazu Giga
Publikováno v:
Patterns
Summary Machine learning is expected to improve low throughput and high assay cost in cell-based phenotypic screening. However, it is still a challenge to apply machine learning to achieving sufficiently complex phenotypic screening due to imbalanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9c830b53dec2185eb3fcd7a1646df3
https://doi.org/10.1016/j.patter.2020.100140
https://doi.org/10.1016/j.patter.2020.100140
Autor:
Tatsuki Yasuda, Takeshi Niki, Sanae M.M. Iguchi-Ariga, Hiroyoshi Ariga, Yoshiro Saito, Asami Okamoto, Kazuko Takahashi-Niki, Jinro Endo
Publikováno v:
Brain Research. 1729:146641
DJ-1 was identified as an oncogene and also as a causative gene for a familial form of Parkinson disease (PD). DJ-1 plays various roles in anti-oxidative stress response. Superfluous oxidation of DJ-1 at cysteine residue 106 (C106), an inactive form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520940f2b894e64c6763aa687ac4260e
https://doi.org/10.1016/j.brainres.2019.146641
https://doi.org/10.1016/j.brainres.2019.146641
Publikováno v:
Stem Cell Research, Vol 34, Iss, Pp-(2019)
Angelman syndrome is a rare neurodevelopmental disorder caused by the loss of function of the maternally expressed E3 ubiquitin ligase UBE3A. We established human induced pluripotent stem cells (iPSCs) from an Angelman syndrome patient with the delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84325d3540e51f9829a608d1227988cb
https://pubmed.ncbi.nlm.nih.gov/30605843
https://pubmed.ncbi.nlm.nih.gov/30605843
Autor:
Kotaro Suzuki, Naruyuki Michitani, Mai Sasaki, Kazuko Takahashi-Niki, Sanae M.M. Iguchi-Ariga, Ayako Inafune, Hiroyoshi Ariga, Yoshitaka Hatakeyama, Takeshi Niki, Yoshihisa Kitamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 305-310 (2015)
Parkinson's disease (PD) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. Oxidative stress is one of the causes of PD. Since symptomatic PD therapies are used, identification of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf7c5f18acabddb4870b3c15acebe20
Publikováno v:
Advances in experimental medicine and biology. 1037
DJ-1 is an oncogene and also a causative gene for familial Parkinson's disease. DJ-1 has various functions, and the oxidative status of a cysteine residue at position 106 (C106) is crucial for determination of the activation level of DJ-1.DJ-1 binds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2be5d0d17bc8a972ab2f3413727709e2
https://pubmed.ncbi.nlm.nih.gov/29147905
https://pubmed.ncbi.nlm.nih.gov/29147905
Publikováno v:
Free radical research. 51(4)
DJ-1 is a causative gene for familial Parkinson's disease (PD). Loss-of-function of DJ-1 protein is suggested to contribute to the onset of PD, but the causes of DJ-1 dysfunction remain insufficiently elucidated. In this study, we found that the SDS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b938308288cadad0998b698b68d91e
https://pubmed.ncbi.nlm.nih.gov/28446034
https://pubmed.ncbi.nlm.nih.gov/28446034
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811065828
DJ-1 is an oncogene and also a causative gene for familial Parkinson's disease. DJ-1 has various functions, and the oxidative status of a cysteine residue at position 106 (C106) is crucial for determination of the activation level of DJ-1.DJ-1 binds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df9b09883d0c053cd210977d47bec6ad
https://doi.org/10.1007/978-981-10-6583-5_7
https://doi.org/10.1007/978-981-10-6583-5_7
