Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Takeshi Matsugi"'
Autor:
Naoto Mori, Takaharu Mochizuki, Fumiyoshi Yamazaki, Shiro Takei, Hidetoshi Mano, Takeshi Matsugi, Mitsutoshi Setou
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211376 (2019)
It is essential to elucidate drug distribution in the ocular tissues and drug transit in the eye for ophthalmic pharmaceutical manufacturers. Atropine is a reversible muscarinic receptor used to treat various diseases. However, its distribution in oc
Externí odkaz:
https://doaj.org/article/3892cd948d8040a6a250d478a67eb7b9
Autor:
Yasuko Yamamoto, Naveed K Shams, Tomoaki Inazumi, Yukihiko Sugimoto, Takazumi Taniguchi, Ryo Iwamura, Kenji Yoneda, Takeshi Matsugi, Noriko Odani-Kawabata
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics
Purpose: We aimed at comparing the effects of omidenepag (OMD) with those of prostaglandin F (FP) receptor agonists (FP agonists) on adipogenesis in mouse 3T3-L1 cells. Methods: To evaluate the agonistic activities of OMD against the mouse EP2 (mEP2)
Effect of Diquafosol Ophthalmic Solution on Airflow-Induced Ocular Surface Disorder in Diabetic Rats
Publikováno v:
Clinical Ophthalmology. 14:1019-1024
Purpose To examine the effect of 3% diquafosol ophthalmic solution (DQS) on ocular surface disorders in diabetic model rats maintained in a continuous airflow condition. Methods Goto-Kakizaki (GK) rats, a spontaneous model of type 2 diabetes, were ex
Autor:
Kenji Yoneda, Shan Fan, Carol B. Toris, Masaki Ichikawa, Masahiro Fuwa, Ryo Iwamura, Jin-Zhong Zhang, Takeshi Matsugi, Naveed K Shams, Noriko Odani-Kawabata, Takazumi Taniguchi
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 34:531-537
To investigate the mechanism of the intraocular pressure (IOP)-lowering effect of a novel selective prostaglandin E2 receptor 2 (EP2) receptor agonist, omidenepag isopropyl (OMDI).The effect of OMDI on IOP and aqueous humor dynamics was evaluated in
Effect of Diquafosol Ophthalmic Solution on Airflow-Induced Ocular Surface Disorder in Diabetic Rats
Publikováno v:
Clinical Ophthalmology (Auckland, N.Z.)
Purpose To examine the effect of 3% diquafosol ophthalmic solution (DQS) on ocular surface disorders in diabetic model rats maintained in a continuous airflow condition. Methods Goto–Kakizaki (GK) rats, a spontaneous model of type 2 diabetes, were
Autor:
Mark C Gillies, Weiyong Shen, Jin-Zhong Zhang, Ting Zhang, Ling Zhu, Ashish Easow Mathai, Michelle Yam, Keiichi Shibagaki, So-Ra Lee, Victoria Pye, Takeshi Matsugi
Publikováno v:
Investigative ophthalmologyvisual science. 59(15)
Purpose Subretinal fibroneovascularization is one of the most common causes of vision loss in neovascular AMD (nAMD). Anti-VEGF therapy effectively inhibits vascular leak and neovascularization but has little effect on fibrosis. This study aimed to i
Autor:
Naoto Mori, Takaharu Mochizuki, Fumiyoshi Yamazaki, Shiro Takei, Hidetoshi Mano, Takeshi Matsugi, Mitsutoshi Setou
Matrix-assisted laser desorption/ionization–imaging mass spectrometry (MALDI-IMS) evaluates drug distribution in biological samples. However, there have been few investigations of drug distribution in ocular tissues, including whole-eye segments. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f93b789661928ee9d909425eadf3a3a
https://doi.org/10.17504/protocols.io.v7ae9ie
https://doi.org/10.17504/protocols.io.v7ae9ie
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Autor:
Takazumi Taniguchi, Noriko Odani-Kawabata, Tomoko Kirihara, Atsushi Shimazaki, Kenzo Yamamura, Kenji Yoneda, Takeshi Matsugi, Jin-Zhong Zhang, Naveed K Shams, Ryo Iwamura
Publikováno v:
Investigative Opthalmology & Visual Science. 59:145
Purpose The objective of this study was to investigate the pharmacologic characteristics of omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure (IOP)-lowering agent, with better IOP control and fewer side effects than ot
Autor:
Takeshi Suzuki, Mihoko Hirata, Koichiro Kawashima, Yoshihisa Kudo, Takeshi Nakamura, Masaru Kanagawa, Takeshi Matsugi, Ryoichi Takagi
Publikováno v:
Neuroscience Letters. 311:89-92
We examined the development of cholinergic neuronal functions and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) responses in cultured embryonic rat septal cells. Choline acetyltransferase activity was increased from 4 to 6 days in