Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Takeshi Kunimatsu"'
Autor:
Akihiko Kiyoshi, Isao Shimizu, Yasunori Katsura, Tadashi Tsubouchi, Kiyoko Bando, Seiko Oku, Shinji Tsujimoto, Toru Yamada, Kazuhiro Chihara, Yukiko Mine, Takeshi Kunimatsu
Publikováno v:
European Journal of Pharmacology. 826:96-105
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonists. DSP-6952 had a strong affinity of K i = 51.9 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::840f70dc774d7cf9b312025373d5c8ab
https://doi.org/10.1016/j.ejphar.2018.02.037
https://doi.org/10.1016/j.ejphar.2018.02.037
Autor:
Hiroko Endo, Junko Shinozaki, Kaori Miyamoto, Chiho Nagasawa, Hitoshi Watanabe, Shinobu Suzuki, Shota Saiki, Chiaki Nakamori, Kiyotaka Koyabu, Yayoi Honda, Chiaki Nakayama, Ikumi Washio, Takeshi Kunimatsu, Hisashi Nogawa, Hiroshi Iwasaki, Etsushi Takahashi, Yumiko Nozaki, Atsuhiro Yamanishi, Tetsuji Itoh
Publikováno v:
Regulatory Toxicology and Pharmacology. 77:75-86
In vitro screening of hERG channels are recommended under ICH S7B guidelines to predict drug-induced QT prolongation and Torsade de Pointes (TdP), whereas proarrhythmia is known to be evoked by blockage of other ion channels involved in cardiac contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c3022873eb82f6c37aaf1b87424a3a
https://doi.org/10.1016/j.yrtph.2016.02.007
https://doi.org/10.1016/j.yrtph.2016.02.007
Autor:
Tadashi, Tsubouchi, Takeshi, Kunimatsu, Shinji, Tsujimoto, Akihiko, Kiyoshi, Yasunori, Katsura, Seiko, Oku, Kazuhiro, Chihara, Yukiko, Mine, Toru, Yamada, Isao, Shimizu, Kiyoko, Bando
Publikováno v:
European journal of pharmacology. 826
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91091cee40ec448cdde13f1ae75e75c8
https://pubmed.ncbi.nlm.nih.gov/29501863
https://pubmed.ncbi.nlm.nih.gov/29501863
Autor:
Hitoshi Funabashi, Hitoshi Watanabe, Shinji Tsujimoto, Yayoi Honda, Yumiko Nozaki, Takeshi Kunimatsu
Publikováno v:
Toxicology and Applied Pharmacology. 278:72-77
Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ad8b84740e8e6f052c70c29a002695
https://doi.org/10.1016/j.taap.2014.04.007
https://doi.org/10.1016/j.taap.2014.04.007
Autor:
Takeshi Kunimatsu, Atsushi Yabunaka, Satoki Imai, Noriko Okahashi, Masashi Yabuki, Yohei Nishizato
Publikováno v:
Toxicology in Vitro. 28:397-402
SMP-028 is a new compound for treatment of asthma. Oral administration of SMP-028 to rats was associated with toxicological events in endocrine organs. These events mainly consisted of pathological changes in the adrenal gland, testis, prostate, semi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4af09e5f6b778144b0ea3be1aa28d0
https://doi.org/10.1016/j.tiv.2013.12.005
https://doi.org/10.1016/j.tiv.2013.12.005
Autor:
Juki Kimura, Hitoshi Funabashi, Hiroshi Inada, Izumi Matsumoto, Izuru Miyawaki, Akitoshi Tamura, Takeshi Kunimatsu
Publikováno v:
Toxicology and Applied Pharmacology. 265:351-359
Clobazam (CLB) is known to increase hepatobiliary thyroxine (T4) clearance in Sprague-Dawley (SD) rats, which results in hypothyroidism followed by thyroid follicular cell hypertrophy. However, the mechanism of the acceleration of T4-clearance has no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c44509faa97e033d240b7d07b233a
https://doi.org/10.1016/j.taap.2012.09.003
https://doi.org/10.1016/j.taap.2012.09.003
Autor:
Hiroyuki Ando, Takashi Kitaguchi, Takeshi Kunimatsu, Katsuyuki Kazusa, Kiyoshi Takasuna, Sei-ichi Araki, Norimasa Miyamoto, Shinobu Suzuki, Keiichi Asakura
Publikováno v:
Journal of pharmacological and toxicological methods. 83
Recent increasing evidence suggests that the currently-used platforms in vitro IKr and APD, and/or in vivo QT assays are not fully predictive for TdP, and do not address potential arrhythmia (VT and/or VF) induced by diverse mechanisms of action. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cad655f24aa1f9be03e970742459f2
https://pubmed.ncbi.nlm.nih.gov/27646297
https://pubmed.ncbi.nlm.nih.gov/27646297
Autor:
Izuru Miyawaki, Kazuhiro Chihara, Hiroshi Inada, Yumi Tateishi, Juki Kimura, Hitoshi Funabashi, Takashi Miyano, Takeshi Kunimatsu, Akihito Yamashita, Chiharu Fukuda
Publikováno v:
The Journal of Toxicological Sciences. 37:483-490
Mono-(2-ethylhexyl) phthalate (MEHP) is the most toxic metabolite of di-(2-ethylhexyl) phthalate (DEHP). It has been reported that DEHP causes abnormal reproductive development in women, and suppresses estradiol synthesis and ovulation in female rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dac3d4971b4bad387dda613b7f3988
https://doi.org/10.2131/jts.37.483
https://doi.org/10.2131/jts.37.483
Publikováno v:
Regulatory Toxicology and Pharmacology. 58:360-368
The main objective of this study was to evaluate the effects of the antipsychotic drugs haloperidol (HAL) and chlorpromazine (CPZ) on bone mineral density (BMD) in female rats and to examine the relationship between the effects on bone and reproducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c08dfc16c4a02a62a12a300810e2e2
https://doi.org/10.1016/j.yrtph.2010.08.001
https://doi.org/10.1016/j.yrtph.2010.08.001
Autor:
Juki Kimura, Kiyoko Bando, Takeshi Kunimatsu, Shoko Ochiai, Jiro Deguchi, Hitoshi Funabashi, Takaki Seki
Publikováno v:
Regulatory Toxicology and Pharmacology. 58:155-160
Lactic acidosis has been considered to be a side effect of some biguanides, after phenformin was withdrawn from the market because of its association with lactic acidosis. The potential of lactic acidosis induced by biguanides at human therapeutic ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5dc3e1b996c8862324d9875c0c0a59
https://doi.org/10.1016/j.yrtph.2010.05.005
https://doi.org/10.1016/j.yrtph.2010.05.005