Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Takeshi Iwasaki"'
Autor:
Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Koichiro Ohmura, Hiroyuki Yoshitomi, Koichi Murata, Kosaku Murakami, Akira Onishi, Masao Tanaka, Shuichi Matsuda, Fumihiko Matsuda, Akio Morinobu, Motomu Hashimoto
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-11 (2024)
Abstract Background The biological mechanisms underlying the differential response to abatacept in patients with rheumatoid arthritis (RA) are unknown. Here, we aimed to identify cellular, transcriptomic, and proteomic features that predict resistanc
Externí odkaz:
https://doaj.org/article/349a98cfe73040428b6ad347d65b135d
Autor:
Takeshi Iwasaki, Kazuhiko Hayashi, Michiko Matsushita, Daisuke Nonaka, Takamasa Matsumoto, Midori Taniguchi, Satoshi Kuwamoto, Yoshihisa Umekita, Yoshinao Oda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The pathogenesis of 80% of Merkel cell carcinoma (MCC) cases is associated with Merkel cell polyomavirus (MCPyV). Forkhead helix transcription factor P3 (FOXP3) and the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-ba
Externí odkaz:
https://doaj.org/article/4818982edfac4958b7e91cbf8a730c43
Autor:
Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki, Mahoko Ueda, Yoshinao Oda, Kazuhiko Yamamoto, Yuta Kochi, Yoshihiro Baba
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathog
Externí odkaz:
https://doaj.org/article/a234cc3fadbb43ac865e2196a80d4551
Autor:
Yoshie Gon, Tsugumitsu Kandou, Tatsuaki Tsuruyama, Takeshi Iwasaki, Koji Kitagori, Kosaku Murakami, Ran Nakashima, Shuji Akizuki, Akio Morinobu, Masaki Hikida, Tsuneyo Mimori, Hajime Yoshifuji
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0279389 (2023)
Immunoglobulin (Ig) G4 is an IgG subclass that can exhibit inhibitory functions under certain conditions because of its capacity to carry out Fab-arm exchange, inability to form immune complexes, and lack of antibody-dependent and complement-dependen
Externí odkaz:
https://doaj.org/article/6aa6a1b0e0924932ba2ead911511fd49
Autor:
Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111929- (2023)
Summary: The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular impo
Externí odkaz:
https://doaj.org/article/36523fb8ccbc455a9c49d7317c9ee01e
Autor:
Takeshi Iwasaki, Yoichiro Kamatani, Kazuhiro Sonomura, Shuji Kawaguchi, Takahisa Kawaguchi, Meiko Takahashi, Koichiro Ohmura, Taka-Aki Sato, Fumihiko Matsuda
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105738- (2023)
Summary: An increase in ethnic diversity in genetic studies has the potential to provide unprecedented insights into how genetic variations influence human phenotypes. In this study, we conducted a quantitative trait locus (QTL) analysis of 121 metab
Externí odkaz:
https://doaj.org/article/8c693a9441bf47989f2c23676755dc2a
Autor:
Hiroki Mukoyama, Mirei Shirakashi, Nozomi Tanaka, Takeshi Iwasaki, Toshiki Nakajima, Hideo Onizawa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Masao Tanaka, Akio Morinobu, Hajime Yoshifuji
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-9 (2021)
Abstract Background Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified. Methods We retrospectively investigated 166 consecutive patients w
Externí odkaz:
https://doaj.org/article/5f28c73e92f64a95abaa15482ad0e71e
Autor:
Keiichiro Kadoba, Ryu Watanabe, Takeshi Iwasaki, Toshiki Nakajima, Koji Kitagori, Shuji Akizuki, Kosaku Murakami, Ran Nakashima, Motomu Hashimoto, Masao Tanaka, Koichiro Ohmura, Akio Morinobu, Chikashi Terao, Hajime Yoshifuji
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract HLA-B*52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3 (rs103294) were newly identified as non-HLA susceptibility loci in TAK. Here, we examined
Externí odkaz:
https://doaj.org/article/f9e1ab64075742b083494f7b8b797a97
Autor:
Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Kenji Okuma, Takuma Oku, Yoshitaka Hirayama, Koichiro Ohmura, Koichi Murata, Kosaku Murakami, Hiroyuki Yoshitomi, Masao Tanaka, Shuichi Matsuda, Fumihiko Matsuda, Akio Morinobu, Motomu Hashimoto
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The factors influencing long-term responses to a tumor necrosis factor inhibitor (TNFi) in rheumatoid arthritis (RA) patients currently remain unknown. Therefore, we herein conducted a multi-omics analysis of TNFi responses in a Japanese RA cohort. B
Externí odkaz:
https://doaj.org/article/9145474307c14f30a6acaadba2dbc46b
Autor:
Takeshi Iwasaki, Shuichiro Nakabo, Chikashi Terao, Kosaku Murakami, Ran Nakashima, Motomu Hashimoto, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Yasuo Miura, Kimiko Yurugi, Taira Maekawa, Myrthe A. M. van Delft, Leendert A. Trouw, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)
Abstract Background The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP antibody and, thus, may
Externí odkaz:
https://doaj.org/article/c195d9a8f7024b4584db27527af4faa3