Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Takeshi Ishigaki"'
Autor:
Masashi Uchida, Mitsuko Miyamoto, Mika Kitsukawa, Masafumi Isogaya, Ryoji Hayashi, Kuniaki Kawamura, Takeshi Ishigaki, Yasuhiro Morita, Katsuhiko Iseki
Publikováno v:
Molecules, Vol 17, Iss 2, Pp 1233-1246 (2012)
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl
Externí odkaz:
https://doaj.org/article/cba6f75255bc410fb2073936b36728ea
Autor:
Takeshi Ishigaki, Ryoji Hayashi, Masafumi Isogaya, Mitsuko Miyamoto, Yasuhiro Morita, Hiroaki Ito
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2886-2889
We searched for a strong and selective nonprostanoid IP agonist bearing piperidine and benzanilide moieties. Through optimization of substituents on the benzanilide moiety, the crucial part of the agonist, 43 (2-((1-(2-(N-(4-tolyl)benzo[d][1,3]dioxol
Autor:
Yoshifumi Imamura, Tsuyoshi Mutou, Kiyoyuki Yamada, Kiyotake Suenaga, Takeshi Ishigaki, Makoto Ojika, Akira Sakakura, Hideo Kigoshi, Kohji Yoshikawa
Publikováno v:
Tetrahedron. 68:982-987
Five cytotoxic macrolides, aplyronines D–H (4–8), were isolated from the Japanese sea hare Aplysia kurodai. They are new congeners of the antitumor compound aplyronine A (1), which was previously isolated from the same organism. Their structures
Autor:
Tsuyoshi Mutou, Kiyotake Suenaga, Hiroyuki Ishiwata, Hideo Kigoshi, Akira Sakakura, Makoto Ojika, Takeshi Ogawa, Toshiyuki Atsumi, Takeshi Ishigaki, Kiyoyuki Yamada
Publikováno v:
The Journal of Organic Chemistry. 61:5326-5351
The enantioselective total synthesis of aplyronine A (1), a potent antitumor substance of marine origin, was achieved by a convergent approach. Three segments 4, 5, and 6, corresponding to the C5−C11, C21−C27, and C28−C34 portions of aplyronine
Publikováno v:
Tetrahedron Letters. 36:5053-5056
Synthesis of aplyronines B and C, the congeners of aplyronine A, was achieved enantioselectively, which established their stereostructures.
Autor:
Kuniaki Kawamura, Mika Kitsukawa, Masashi Uchida, Mitsuko Miyamoto, Katsuhiko Iseki, Yasuhiro Morita, Ryoji Hayashi, Masafumi Isogaya, Takeshi Ishigaki
Publikováno v:
Molecules
Molecules, Vol 17, Iss 2, Pp 1233-1246 (2012)
Volume 17
Issue 2
Pages 1233-1246
Molecules, Vol 17, Iss 2, Pp 1233-1246 (2012)
Volume 17
Issue 2
Pages 1233-1246
An efficient synthesis of a highly potent and selective IP (PGI(2) receptor) agonist that is not structurally analogous to PGI(2) is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chloroph
Publikováno v:
Tetrahedron Letters. 34:8501-8504
By a series of reactions aplyronine A ( 1 ) an antitumor substance of marine origin was transformed into six fragments, and their structures were characterized by spectroscopic methods. Relative stereochemistry of four contiguous chiral centers (C29
Autor:
Kiyoyuki Yamada, Makoto Ojika, Masanori Nisiwaki, Itaru Tsukada, Kazuhiro Mizuta, Takeshi Ishigaki, Hideo Kigoshi
Publikováno v:
Tetrahedron Letters. 34:8505-8508
The absolute stereochemistry of the C21C34 fragment 2 of aplyronine A (1), a potent antitumor substance of marine origin, was determined by enantioselective synthesis.
Autor:
M. Ikagawa, Masanori Nisiwaki, Hiroyuki Niwa, Kazumasa Wakamatsu, Tatsuya Mori, Suketoshi Ito, Kazumasa Yamada, Itaru Tsukada, Takeshi Ishigaki
Publikováno v:
ChemInform. 22
Autor:
Kiyoyuki Yamada, Itaru Tsukada, Kazuhiro Mizuta, Takeshi Ishigaki, Masanori Nisiwaki, Makoto Ojika, Hideo Kigoshi
Publikováno v:
ChemInform. 25