Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Takeshi Imanishi"'
Autor:
Takeshi Imanishi, Satoshi Obika, Futaba Makimura, Ayako Orita, Tomohisa Osaki, Noritsugu Hosoki, Tetsuya Kodama, Kosuke Ramon Ito
Publikováno v:
Molecules, Vol 16, Iss 12, Pp 10695-10708 (2011)
Double-stranded DNA (dsDNA) templates can hybridize to and accelerate cleavage of oligonucleotides containing a P3’→N5’ phosphoramidate (P-N) linkage. This dsDNA-templated cleavage of P-N linkages could be due to conformational strain placed on
Externí odkaz:
https://doaj.org/article/83b6fbe2af6a4f4fb31b6911553fb1f9
Autor:
Tsuyoshi Yamamoto, Hidenori Yasuhara, Fumito Wada, Mariko Harada-Shiba, Takeshi Imanishi, Satoshi Obika
Publikováno v:
Journal of Nucleic Acids, Vol 2012 (2012)
The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2′,4′-BNANC antisense oligonucleotides (AONs) ranging from 10- to 20-nt-long, targeted apolipoprotein B.
Externí odkaz:
https://doaj.org/article/847ece0d41d04df6a535804f9fbc3856
Autor:
Tsuyoshi Yamamoto, Mariko Harada-Shiba, Moeka Nakatani, Shunsuke Wada, Hidenori Yasuhara, Keisuke Narukawa, Kiyomi Sasaki, Masa-Aki Shibata, Hidetaka Torigoe, Tetsuji Yamaoka, Takeshi Imanishi, Satoshi Obika
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonuc
Externí odkaz:
https://doaj.org/article/2e206c7e3b2d4e9f9e1170bbf0385502
Autor:
Takeshi Imanishi, Haruhisa Yoshikawa, Aki Fujisaka, Hiroko Takuma, Yoshiyuki Hari, Juanjuan Pang, Satoshi Obika, S. M. Abdur Rahman
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1728-1741
We efficiently synthesized 2'-O,4'-C-aminomethylene-bridged nucleic acid (2',4'-BNANC) monomers bearing the four nucleobases, guanine, adenine, thymine, and 5-methylcytosine and incorporated these monomers into oligonucleotides. Initially, we carried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2e6cccc43ae4875c670a86acd6da6e
https://doi.org/10.1016/j.bmc.2019.02.034
https://doi.org/10.1016/j.bmc.2019.02.034
Autor:
Shinichi, Hattori, Souichi, Mugiya, Yutaka, Kurita, Shigenori, Sato, Takeshi, Imanishi, Shin, Kasugai
Publikováno v:
Hinyokika kiyo. Acta urologica Japonica. 67(1)
A 70-year-old man complaining of pain in his right leg presented to the Department of Orthopedics in our hospital. X-ray findings revealed calcifications around the left kidney. He was referred to our department for further examination. Computed tomo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fdd75b0f911b577218153fcb85221b8
https://pubmed.ncbi.nlm.nih.gov/33535291
https://pubmed.ncbi.nlm.nih.gov/33535291
Autor:
Aki, Fujisaka, Yoshiyuki, Hari, Hiroko, Takuma, S M Abdur, Rahman, Haruhisa, Yoshikawa, Juanjuan, Pang, Takeshi, Imanishi, Satoshi, Obika
Publikováno v:
Bioorganicmedicinal chemistry. 27(8)
We efficiently synthesized 2'-O,4'-C-aminomethylene-bridged nucleic acid (2',4'-BNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1960d1a92a8eee4b0c3f31791173312
https://pubmed.ncbi.nlm.nih.gov/30862430
https://pubmed.ncbi.nlm.nih.gov/30862430
Publikováno v:
Nucleic Acid Therapeutics. 24:186-191
Gene knockdowns using oligonucleotide-based approaches are useful for studying gene function in both in vitro cell culture systems and in vivo animal models. We evaluated the efficacy of 2',4'-bridged nucleic acids (BNA)-modified antisense oligonucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4a0551d7adbde169eac60d8295f162
https://doi.org/10.1089/nat.2013.0464
https://doi.org/10.1089/nat.2013.0464
Publikováno v:
Tetrahedron. 69:6810-6820
Novel dendrimers having an adamantane structure as a core were synthesized such that even low generation dendrimers had a globular structure. Moreover we tried to give them biodegradable function by using ester bonds. Synthesis of the dendrimers, par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03efa110e621ce7d91ecee8dca5d3df
https://doi.org/10.1016/j.tet.2013.06.024
https://doi.org/10.1016/j.tet.2013.06.024
Autor:
Takeshi Imanishi, Satoshi Obika, Hiroyasu Inohara, Yoshiyuki Hari, Shin Ijitsu, Satoshi Kashima
Publikováno v:
Tetrahedron. 69:6381-6391
Oligonucleotides containing 2′-deoxyribonucleotides bearing hydroxyphenyl nucleobases or their 2′,4′-BNA-modified analogs were synthesized, and the triplex-forming ability of their oligonucleotides with double-stranded DNA targets was evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04a74045aaae65cc5166195077c04a96
https://doi.org/10.1016/j.tet.2013.05.107
https://doi.org/10.1016/j.tet.2013.05.107
Autor:
Yoshiko Chihara, Kazuyuki Miyashita, Takao Yamaguchi, Takeshi Imanishi, Masahiro Ikejiri, Moe Tsuchino, Satoshi Obika
Publikováno v:
Organic Letters. 14:4406-4409
A small molecular model compound for the green fluorescent protein chromophore was readily synthesized by a novel condensation reaction of (thio)imidate with imino-ester via an aziridine intermediate. This compound showed fluorescence in the solid an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3662a0c73118d1935c19a13b0c4e7bd1
https://doi.org/10.1021/ol301901e
https://doi.org/10.1021/ol301901e