Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Takeshi Ichinohe"'
Autor:
Isaiah Song, Jiayue Yang, Misa Saito, Tenagy Hartanto, Yasunori Nakayama, Takeshi Ichinohe, Shinji Fukuda
Publikováno v:
npj Science of Food, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract Current treatment options for COVID-19 are limited, with many antivirals and immunomodulators restricted to the most severe cases and preventative care limited to vaccination. As the SARS-CoV-2 virus and its increasing variants threaten to b
Externí odkaz:
https://doaj.org/article/ea3cfa4f76ee4ef3a2f2ce84b271255f
Autor:
Minami Nagai, Miyu Moriyama, Chiharu Ishii, Hirotake Mori, Hikaru Watanabe, Taku Nakahara, Takuji Yamada, Dai Ishikawa, Takamasa Ishikawa, Akiyoshi Hirayama, Ikuo Kimura, Akihito Nagahara, Toshio Naito, Shinji Fukuda, Takeshi Ichinohe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Fever is a common symptom of influenza and coronavirus disease 2019 (COVID-19), yet its physiological role in host resistance to viral infection remains less clear. Here, we demonstrate that exposure of mice to the high ambient temperature o
Externí odkaz:
https://doaj.org/article/751754dc12254778afd6f740e9152c9e
Autor:
Tetsu Tatsuma, Makoto Nakakido, Takeshi Ichinohe, Yoshinori Kuroiwa, Kengo Tomioka, Chang Liu, Nobuhiro Miyamae, Tatsuya Onuki, Kouhei Tsumoto, Kazuhito Hashimoto, Toru Wakihara
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract In order to reduce infection risk of novel coronavirus (SARS-CoV-2), we developed nano-photocatalysts with nanoscale rutile TiO2 (4–8 nm) and Cu x O (1–2 nm or less). Their extraordinarily small size leads to high dispersity and good opt
Externí odkaz:
https://doaj.org/article/ec53887b834041e5b5b8954fadf6a5ff
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The gut microbiota plays a critical role in the induction of adaptive immune responses to influenza virus infection. However, the role of nasal bacteria in the induction of the virus-specific adaptive immunity is less clear. Here, we found t
Externí odkaz:
https://doaj.org/article/fc326cd3ad2c47479886d603cebf136d
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cytosolic mitochondrial DNA (mtDNA) plays a role in innate antiviral immunity but how this is triggered during infection remains unclear. Here, the authors provide evidence that the Influenza virus protein M2 stimulates translocation of mtDNA into th
Externí odkaz:
https://doaj.org/article/0b79c42b444a4fddaa8705575ccaf3a8
Autor:
Miyu Moriyama, Minami Nagai, Yuhei Maruzuru, Takumi Koshiba, Yasushi Kawaguchi, Takeshi Ichinohe
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101270- (2020)
Summary: Influenza virus M2 and PB1-F2 proteins have been proposed to activate the Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in macrophages by altering intracellular ionic balance or mitochondrial reactive oxygen specie
Externí odkaz:
https://doaj.org/article/7d9946dcf2dc4933a73b3ac1c9bc2402
Autor:
Shin-Ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, Natsuko Tanimura, Yoshiko Mori Saitoh, Ryutaro Fukui, Takuma Shibata, Katsuaki Sato, Takeshi Ichinohe, Mayumi Hayashi, Kazuishi Kubota, Hiroko Kozuka-Hata, Masaaki Oyama, Yorifumi Kikko, Toshiaki Katada, Kenji Kontani, Kensuke Miyake
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7+ endosomes to the periphery of the
Externí odkaz:
https://doaj.org/article/f3a96501c2b548c493e42bf4711580c2
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stim
Externí odkaz:
https://doaj.org/article/07a907f3222b4976945cd071e30ef983
Autor:
Tetsu Tatsuma, Makoto Nakakido, Takeshi Ichinohe, Yoshinori Kuroiwa, Kengo Tomioka, Chang Liu, Nobuhiro Miyamae, Tatsuya Onuki, Kouhei Tsumoto, Kazuhito Hashimoto, Toru Wakihara
Publikováno v:
Scientific Reports. 13
In order to reduce infection risk of novel coronavirus (SARS-CoV-2), we developed nano-photocatalysts with nanoscale rutile TiO2 (4–8 nm) and CuxO (1–2 nm or less). Their extraordinarily small size leads to high dispersity and good optical transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1658b5df69388d7b62b4af0bae63817
https://doi.org/10.1038/s41598-023-30690-0
https://doi.org/10.1038/s41598-023-30690-0
Autor:
Mizuki Yamamoto, Takeshi Ichinohe, Aya Watanabe, Ayako Kobayashi, Rui Zhang, Jiping Song, Yasushi Kawaguchi, Zene Matsuda, Jun-ichiro Inoue
Publikováno v:
Viruses, Vol 12, Iss 12, p 1475 (2020)
Flaviviruses bear class II fusion proteins as their envelope (E) proteins. Here, we describe the development of an in vitro quantitative mosquito-cell-based membrane-fusion assay for the E protein using dual split proteins (DSPs). The assay does not
Externí odkaz:
https://doaj.org/article/7dfc3336caeb4f36a8a03c79f0956976