Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Takeshi Hosaka"'
Autor:
Keiichiro Mukai, Takeshi Hosaka, Ryoko Hamauzu, Kanata Hoshino, Tomoko Maruyama, Daiki Hayashi, Momoko Kobayashi
Publikováno v:
Current Microbiology. 77:2933-2939
Activating the genetic potential of Streptomyces strains to produce secondary metabolites can improve the production of useful biologically active compounds and facilitate the discovery of novel biologically active compounds. In this study, we found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8684a00c583b4f97ce1ac6f311ccce
https://doi.org/10.1007/s00284-020-02126-9
https://doi.org/10.1007/s00284-020-02126-9
Publikováno v:
Applied Microbiology and Biotechnology. 104:2193-2203
Mutations in rrn encoding ribosomal RNA (rRNA) and rRNA modification often confer resistance to ribosome-targeting antibiotics by altering the site of their interaction with the small (30S) and large (50S) subunits of the bacterial ribosome. The high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789dbabd6cf9a8ed0ade2adc59659d12
https://doi.org/10.1007/s00253-019-10288-1
https://doi.org/10.1007/s00253-019-10288-1
Publikováno v:
Applied and Environmental Microbiology. 88
The abuse or overuse of antibacterial agents for therapy and animal husbandry has caused an increased population of antimicrobial-resistant bacteria in the environment. Consequently, fewer effective antimicrobials are now available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51daf01c533c45284512a55eb5748d11
https://doi.org/10.1128/aem.02327-21
https://doi.org/10.1128/aem.02327-21
Autor:
Takanori Oyoshi, Shinya Kodani, Issara Kaweewan, Kanata Hoshino, Hisayuki Komaki, Gouchi Isokawa, Hikaru Hemmi, Takeshi Hosaka
Publikováno v:
SC10201902280009
NARO成果DBd
NARO成果DBd
Using genome mining, a new cytotoxic peptide named curacozole was isolated from Streptomyces curacoi. Through ESI-MS and NMR analyses, curacozole was determined to be a macrocyclic peptide containing two isoleucine, two thiazole and three oxazole moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4438b9e86d93210709bc5b15ec3325e4
https://doi.org/10.1038/s41429-018-0105-4
https://doi.org/10.1038/s41429-018-0105-4
Autor:
Yu Imai, Kozo Ochi, Keiichiro Mukai, Kazuma Shimono, Misaki Ishizuka, Takeshi Hosaka, Ryoko Hamauzu
Publikováno v:
Antonie van Leeuwenhoek. 111:705-716
Lincomycin forms cross-links within the peptidyl transferase loop region of the 23S ribosomal RNA (rRNA) of the 50S subunit of the bacterial ribosome, which is the site of peptide bond formation, thereby inhibiting protein synthesis. We have previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76b4b8ff571aa4eda6fe1a33972206f
https://doi.org/10.1007/s10482-018-1021-0
https://doi.org/10.1007/s10482-018-1021-0
Autor:
Yoshikazu Hiraga, Kiriko Murakami, Hirofumi Yoshikawa, Takatsugu Miyazaki, Yukinori Tanaka, Nobuyuki Fujita, Shigehachi Gibu, Takeshi Hosaka, Kozo Ochi, Yuh Shiwa, Ken Kasahara, Kazumi Funane, Takashi Inaoka
Publikováno v:
SC30201903060024
NARO成果DBa
出版社版PDFのためアーカイブ不可
NARO成果DBa
出版社版PDFのためアーカイブ不可
This study shows that sequential introduction of drug resistance mutations substantially increased enzyme production in Paenibacillus agaridevorans The triple mutant YT478 (rsmG Gln225→stop codon, rpsL K56R, and rpoB R485H), generated by screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1c03722090ea38965166e802a38c6b
https://doi.org/10.1128/jb.00188-18
https://doi.org/10.1128/jb.00188-18
Publikováno v:
Applied and Environmental Microbiology. 81:3869-3879
Antibiotics have either bactericidal or bacteriostatic activity. However, they also induce considerable gene expression in bacteria when used at subinhibitory concentrations (below the MIC). We found that lincomycin, which inhibits protein synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1e7eb5d26d0cf0fc57c34589c859a1
https://doi.org/10.1128/aem.04214-14
https://doi.org/10.1128/aem.04214-14
Autor:
Takeshi Hosaka, Kozo Ochi
Publikováno v:
Applied Microbiology and Biotechnology
Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each strain contains genes that encode the enzymes to synthesize a plethora of potential secondary metabolites, only a fraction are expressed during fermentation. Interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2240dcefa22c11b46e7d6ef58268fbd4
https://doi.org/10.1007/s00253-012-4551-9
https://doi.org/10.1007/s00253-012-4551-9
Publikováno v:
The Journal of Antibiotics. 65:323-326
Development of the ability to produce secondary metabolites in Streptomyces through the acquisition of erythromycin resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c7ddc954ba1e0c90e26e9a25b2342b
https://doi.org/10.1038/ja.2012.16
https://doi.org/10.1038/ja.2012.16
Publikováno v:
The Journal of Antibiotics. 63:477-481
Genome sequencing projects have revealed many biosynthesis gene clusters for the production of as-yet unknown secondary metabolites, especially in actinomycetes. Here, we report that the rare earth elements, scandium and/or lanthanum, markedly activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65823e39381262c746ab9b3a92c7cbeb
https://doi.org/10.1038/ja.2010.53
https://doi.org/10.1038/ja.2010.53