Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Takeshi Hatani"'
Autor:
Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation
Externí odkaz:
https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
Autor:
Masafumi Takeda, Yasuharu Kanki, Hidetoshi Masumoto, Shunsuke Funakoshi, Takeshi Hatani, Hiroyuki Fukushima, Akashi Izumi-Taguchi, Yusuke Matsui, Teppei Shimamura, Yoshinori Yoshida, Jun K. Yamashita
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 546-556 (2018)
Summary: Here, we find that human-induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM)-fated progenitors (CFPs) that express a tetraspanin family glycoprotein, CD82, almost exclusively differentiate into CMs both in vitro and in vivo. CD8
Externí odkaz:
https://doaj.org/article/d0b7145ff6b94823be86764cceae4e66
Autor:
Yuta Tsujisaka, Takeshi Hatani, Chikako Okubo, Ryo Ito, Azuma Kimura, Megumi Narita, Kazuhisa Chonabayashi, Shunsuke Funakoshi, Antonio Lucena-Cacace, Taro Toyoda, Kenji Osafune, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida
Publikováno v:
Stem Cell Reports. 17:1772-1785
For regenerative cell therapies using pluripotent stem cell (PSC)-derived cells, large quantities of purified cells are required. Magnetic-activated cell sorting (MACS) is a powerful approach to collect target antigen-positive cells; however, it rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d878b522808a83c2f0cb1ff13713631e
https://doi.org/10.1016/j.stemcr.2022.05.003
https://doi.org/10.1016/j.stemcr.2022.05.003
Autor:
Taku Monjo, Tomoyuki Nishimoto, Yuya Fujiwara, Norihisa Tamura, Masako Sasaki, Yoshinori Yoshida, Takeshi Hatani, Chikako Okubo, Shigeru Kondo, Tatsuya Ando, Kenji Miki, Misato Nakanishi-Koakutsu, Tsukasa Sugo, Kenichi Imahashi, Ikue Takei, Yuki Naka, Antonio Lucena-Cacace, Sachiko Imaichi, Megumi Narita, Stephanie C. Napier, Kohei Deguchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
One of the earliest maturation steps in cardiomyocytes (CMs) is the sarcomere protein isoform switch between TNNI1 and TNNI3 (fetal and neonatal/adult troponin I). Here, we generate human induced pluripotent stem cells (hiPSCs) carrying a TNNI1[EmGFP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1caae6fb715db7abebf5f35ec46fe5
https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
Autor:
Yoshihiko Fujita, Moe Hirosawa, Karin Hayashi, Takeshi Hatani, Yoshinori Yoshida, Takuya Yamamoto, Hirohide Saito
Publikováno v:
Science Advances
Human induced pluripotent stem cells (iPSCs) are promising cell resources for cell therapy and drug discovery. However, iPSC-derived differentiated cells are often heterogenous and need purification using a flow cytometer, which has high cost and tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32c5725fc9aea55daa74616ce64693b
https://pubmed.ncbi.nlm.nih.gov/34985961
https://pubmed.ncbi.nlm.nih.gov/34985961
Autor:
Takeshi Hatani, Yuta Tsujisaka, Kenji Miki, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida
Publikováno v:
Circulation. 144
Background: For disease modeling and drug screening using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), matured iPSC-CMs are required to understand the underlying mechanism of diseases and to get the candidate drug’s deleterious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c3a9b1008ee4b7585bc875d29a625f
https://doi.org/10.1161/circ.144.suppl_1.13329
https://doi.org/10.1161/circ.144.suppl_1.13329
Autor:
Manabu Kasamoto, Yoshinori Yoshida, Shunsuke Funakoshi, Takeshi Hatani, Takeshi Kimura, Chikako Okubo
Publikováno v:
Circulation. 144
Rationale: The only treatment for drug-resistant heart failure is heart transplantation, however, it has problems such as donor shortages and rejection. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-cardiomyocytes) are promising s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bb1f45e0f5af2d148422ea5c593aca2
https://doi.org/10.1161/circ.144.suppl_1.11832
https://doi.org/10.1161/circ.144.suppl_1.11832
Autor:
Takeshi, Hatani, Yoshinori, Yoshida
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2320
Myocardial infarction is caused by a lack of oxygen due to blockage of a coronary artery and is a common cause of heart failure. Despite therapeutic advances, the prognosis of patients with heart failure is poor. One of the reasons is that present th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23b30a5f579af45251fac30fb4d4b7ca
https://pubmed.ncbi.nlm.nih.gov/34302665
https://pubmed.ncbi.nlm.nih.gov/34302665
Autor:
Yoshinori Yoshida, Takeshi Hatani
Publikováno v:
Methods in Molecular Biology ISBN: 9781071614839
Myocardial infarction is caused by a lack of oxygen due to blockage of a coronary artery and is a common cause of heart failure. Despite therapeutic advances, the prognosis of patients with heart failure is poor. One of the reasons is that present th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16fca49aa3fcc05c6421ed0c7b7525c5
https://doi.org/10.1007/978-1-0716-1484-6_24
https://doi.org/10.1007/978-1-0716-1484-6_24
Autor:
Masahiro Kimura, Tetsushi Nakao, Shin Watanabe, Yoshinori Yoshida, Osamu Baba, Masataka Nishiga, Takeshi Hatani, Tsukasa Inada, Yui Miyasaka, Naoya Sowa, Shinji Ito, Yasuhiro Nakashima, Yasuhide Kuwabara, Shuhei Tsuji, Hisanori Kiryu, Masayasu Izuhara, Koh Ono, Satoshi Koyama, Kazuya Nagao, Yuya Ide, Tomohiro Nishino, Takahiro Horie, Fumiko Nakazeki, Takeshi Kimura
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Recent high-throughput approaches have revealed a vast number of transcripts with unknown functions. Many of these transcripts are long noncoding RNAs (lncRNAs), and intergenic region-derived lncRNAs are classified as long intergenic noncoding RNAs (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda0f318ed2931064e0b1b32dda80959
http://europepmc.org/articles/PMC7426859
http://europepmc.org/articles/PMC7426859