Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Takeshi Biwa"'
Autor:
Kazumasa, Kurogi, Seigo, Sugiyama, Kenji, Sakamoto, Shinji, Tayama, Shinichi, Nakamura, Takeshi, Biwa, Kunihiko, Matsui, Hisao, Ogawa, Kazuki, Fukuda
Publikováno v:
Journal of Cardiology. 62(2):87-94
Background Many large-scale clinical trials have confirmed that statins are effective in reducing low-density lipoprotein cholesterol (LDL-C) level, resulting in reducing cardiovascular events. Recent studies have focused on the effects of statins on
Autor:
Masakazu Sakai, Seikoh Horiuchi, Akira Miyazaki, Yu-Ichiro Sakamoto, Kyu Kyu Maung, Takeshi Biwa, Hideki Hakamata, Mehtap Yuksel
Publikováno v:
Annals of the New York Academy of Sciences. 902:342-346
Autor:
Takayuki Sasahara, Masakazu Sakai, Yoshichika Anami, Motoaki Shichiri, Toru Takemura, Takeshi Matsumura, Hirofumi Matsuda, Takeshi Biwa, Takeshi Nishikawa
Publikováno v:
Atherosclerosis. 152:347-357
Macrophage-derived foam cells are known to play an essential role in the development and progression of atherosclerotic lesions. Probucol prevents oxidative modification of low-density lipoprotein (LDL) and lowers plasma contents of LDL and high-dens
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 7:14-20
We and other groups have recently demonstrated that oxidized low density lipoprotein (Ox-LDL) induces proliferation of macrophages in vitro. Since previous immunohistochemical studies demonstrated that macrophages and macrophage derived foam cells pr
Autor:
Hideki Hakamata, Takeshi Biwa, Seikoh Horiuchi, Takeshi Matsumura, Masakazu Sakai, Ding Yi, Motoaki Shichiri
Publikováno v:
Annals of the New York Academy of Sciences. 811:378-384
Autor:
Motoaki Shichiri, Kengo Kaneko, Takayuki Sasahara, Yoshichika Anami, Kohji Matsuda, Noboru Furukawa, Takeshi Biwa, Masakazu Sakai, Shinsuke Kiritoshi, Takeshi Matsumura, Tetsuya Shirotani
Publikováno v:
Atherosclerosis. 153(1)
Inflammatory process plays an important role in the development and progression of atherosclerotic lesions. Recently, group-II phospholipase A 2 (PLA 2 ), an inflammatory mediator, was reported to exist in human atherosclerotic lesions and to enhance
Autor:
Masakazu Sakai, Hirofumi Matsuda, Motoaki Shichiri, Toru Takemura, Takeshi Biwa, Takayuki Sasahara, Yoshichika Anami, Shozo Kobori, Takeshi Matsumura
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 19(7)
Abstract —Glucocorticoid, an anti-inflammatory agent, inhibits the development of atherosclerosis in various experimental animal models. This is partially explained by its ability to inhibit smooth muscle cell migration and proliferation in the int
Autor:
Seikoh Horiuchi, Hideki Hakamata, Akira Miyazaki, Motoaki Shichiri, Tatsuhiko Kodama, Takeshi Biwa, Masakazu Sakai, Hiroshi Suzuki
Publikováno v:
The Journal of biological chemistry. 273(43)
We have examined whether certain secreted factor(s) is involved in oxidized low density lipoprotein (Ox-LDL)-induced murine macrophage growth. An antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) effectively inhibited Ox-LDL-
Autor:
Takeshi Matsumura, Shozo Kobori, Takeshi Biwa, Hirofumi Matsuda, Seikoh Horiuchi, Masakazu Sakai, Toru Takemura, Hideki Hakamata, Motoaki Shichiri
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 17(11)
Abstract Recent studies demonstrated that oxidized LDL (Ox-LDL) induces macrophage growth in vitro. The present study was undertaken to elucidate the intracellular signaling pathways for macrophage growth. Ox-LDL initiated a rapid and transient rise
Autor:
Shozo Kobori, Yoshihiro Sato, Masakazu Sakai, Seikoh Horiuchi, Takeshi Matsumura, Hideki Hakamata, Takeshi Biwa, Toru Takemura, Motoaki Shichiri
Publikováno v:
Atherosclerosis. 133(1)
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors ameliorate atherosclerotic diseases in several models of vascular disease. This is largely due to their ability to reduce plasma cholesterol levels in vivo. Proliferation of cellula