Zobrazeno 1 - 10 of 94 pro vyhledávání: '"Takeshi, Kawabe"'
1
Akademický článek
Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state
Autor: Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Naoto Ishii, Jinfang Zhu, Takeshi Kawabe
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
Conventional CD4+ T lymphocytes consist of naïve, foreign antigen-specific memory, and self-antigen-driven memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells tonically proliferate in response to self-antigens an
Externí odkaz: https://doaj.org/article/83a3f84c703d4407bf04d09b3d5470f8
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2
Akademický článek
Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes
Autor: Takeshi Kawabe
Publikováno v: Immunological Medicine, Vol 46, Iss 1, Pp 1-8 (2023)
AbstractCD4+ T lymphocytes play an essential role in adaptive immune responses. In pathogen infection, naïve CD4+ T cells that strongly respond to foreign antigens robustly proliferate to differentiate into effector/memory cells, contributing to eli
Externí odkaz: https://doaj.org/article/4ce965f8020c49838ff5711b159f3145
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4
Akademický článek
Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses
Autor: Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Shunichi Tayama, Akihisa Kawajiri, Takumi Suzuki, Riou Tanaka, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Sprent, Rémy Bosselut, Alan Sher
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Under steady-state conditions, conventional CD4+ T lymphocytes are classically divided into naïve (CD44lo CD62Lhi) and memory (CD44hi CD62Llo) cell compartments. While the latter population is presumed to comprise a mixture of distinct subpopulation
Externí odkaz: https://doaj.org/article/d66f6ac930a24af8947edeb2266a5f97
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5
Akademický článek
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
Autor: Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
CD4+ T cells contain a T-bethigh memory-phenotype (MP) population with innate-like functions. Here the authors characterize the requirements for their differentiation at homeostasis and identify a function for IL-12 that is tonically produced by type
Externí odkaz: https://doaj.org/article/ef3cb49a011444f1ac9d73d4ce336452
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7
Akademický článek
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia
Autor: Taizou Hirano, Toshiaki Kikuchi, Naoki Tode, Arif Santoso, Mitsuhiro Yamada, Yoshiya Mitsuhashi, Riyo Komatsu, Takeshi Kawabe, Takeshi Tanimoto, Naoto Ishii, Yuetsu Tanaka, Hidekazu Nishimura, Toshihiro Nukiwa, Akira Watanabe, Masakazu Ichinose
Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 4, Pp 422-436 (2016)
Abstract Influenza virus epidemics potentially cause pneumonia, which is responsible for much of the mortality due to the excessive immune responses. The role of costimulatory OX40–OX40 ligand (OX40L) interactions has been explored in the non‐inf
Externí odkaz: https://doaj.org/article/e942f85376eb4d95a3acbc6ab194b924
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8
Akademický článek
Author Correction: Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
Autor: Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz: https://doaj.org/article/9eb904a4ce104f109e84bf1e22df22a8
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9
Akademický článek
Germ-Free Conditions Modulate Host Purine Metabolism, Exacerbating Adenine-Induced Kidney Damage
Autor: Eikan Mishima, Mariko Ichijo, Takeshi Kawabe, Koichi Kikuchi, Yukako Akiyama, Takafumi Toyohara, Takehiro Suzuki, Chitose Suzuki, Atsuko Asao, Naoto Ishii, Shinji Fukuda, Takaaki Abe
Publikováno v: Toxins, Vol 12, Iss 9, p 547 (2020)
Alterations in microbiota are known to affect kidney disease conditions. We have previously shown that germ-free conditions exacerbated adenine-induced kidney damage in mice; however, the mechanism by which this occurs has not been elucidated. To exp
Externí odkaz: https://doaj.org/article/684a33b170c540039b4ca6e619c26e35
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10
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis
Autor: Hitoshi Terui, Kenshi Yamasaki, Moyuka Wada-Irimada, Mayuko Onodera-Amagai, Naokazu Hatchome, Masato Mizuashi, Riu Yamashita, Takeshi Kawabe, Naoto Ishii, Takaaki Abe, Yoshihide Asano, Setsuya Aiba
Publikováno v: Science Immunology. 7
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by inflammation of various organs such as skin, kidneys, bones, and brain and the presence of autoantibodies. Although the cause of SLE is not completely understood, environmen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25e8b38832b09cfa8264212e6b086ac2
https://doi.org/10.1126/sciimmunol.abm9811
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