Výsledky vyhledávání - "Takeshi, Hioki"

Prediction of Compound Bioactivities Using Heat-Diffusion Equation

Autor: Makoto Fushimi, Yoshiteru Nishimura, Takeshi Niki, Tadashi Hidaka, Yoshinobu Kawahara, Haruhisa Inoue, Takeshi Hioki, Takagi Terufumi, Keiko Imamura, Satoru Hayashi, Mi Ho Giga, Yoshikazu Giga

Publikováno v: Patterns

Summary Machine learning is expected to improve low throughput and high assay cost in cell-based phenotypic screening. However, it is still a challenge to apply machine learning to achieving sufficiently complex phenotypic screening due to imbalanced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9c830b53dec2185eb3fcd7a1646df3
https://doi.org/10.1016/j.patter.2020.100140

Zobrazit plný text záznamu

Brain Testosterone Deficiency Leads to Down-Regulation of Mitochondrial Gene Expression in Rat Hippocampus Accompanied by a Decline in Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α Expression

Autor: Takeshi Hioki, Shunya Suzuki, Shigeru Morita, Tsuneo Masaki, Megumi Morimoto, Ryuichi Tozawa, Takashi Horiguchi

Publikováno v: Journal of Molecular Neuroscience. 52:531-537

Age-related decrease of testosterone levels in blood and brain is believed to be associated with neurodegenerative diseases such as Alzheimer's disease. However, the effect of testosterone on brain function is not well understood. Therefore, we inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a876cc0a12a5b49bcf5bfe4e9827b3
https://doi.org/10.1007/s12031-013-0108-3

Zobrazit plný text záznamu

Grouping of Observer's Visual Characteristics on the Basis of Difference in the Criteria of Visual Detection and Selection of the Fittest Clustering Method: Verification of Observer's Group with Radiologist-like Visual Characteristics

Autor: Takeshi Hioki, Takanaga Niimi, Kenichi Kamegai, Kuniharu Imai, Akihiro Mano

Publikováno v: Japanese Journal of Radiological Technology. 60:513-519

Various clustering methods are used in cluster analyses, with each clustering method demonstrating unique advantages. Therefore, it is important to make the best use of the advantages each method provides. We have recognized that it is necessary in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147b1852d7d042f46740e148492e8006
https://doi.org/10.6009/jjrt.kj00000922396

Zobrazit plný text záznamu

DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells

Autor: Shigeo Uchino, Takeshi Hioki, Sadayo Nakajima-Iijima, Takehisa Ishii, Mutsuya Yamamoto

Publikováno v: European Journal of Biochemistry. 269:139-147

Exposure of PC12 cells to C(2)-ceramide results in dose- dependent apoptosis. Here, we investigate the involvement of death-associated protein (DAP) kinase, initially identified as a positive mediator of the interferon-gamma-induced apoptosis of HeLa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35892358a62f2266d89cf783fbd80702
https://doi.org/10.1046/j.0014-2956.2002.00029.x

Zobrazit plný text záznamu

Developmental changes in distribution of death-associated protein kinase mRNAs

Autor: Shin Nagayama, Mutsuya Yamamoto, Xiaofen Sun, Takeshi Hioki, Hiroshi Takahashi, Shigeo Uchino, Sadayo Nakajima-Iijima, Noriko Ooashi, Takehisa Ishii, Takeshi Nakamura, Yoshihisa Kudo, Adi Kimchi

Publikováno v: Journal of Neuroscience Research. 58:674-683

Death-associated protein kinase (DAP-kinase) is Ca2+/calmodulin-dependent serine/threonine kinase that contains ankyrin repeats and the death domain. It has been isolated as a positive mediator of interferon-γ-induced apoptotic cell death of HeLa ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c579590f9e98a434e9e1091ab2f37ff0
https://doi.org/10.1002/(sici)1097-4547(19991201)58:5<674::aid-jnr8>3.0.co

Zobrazit plný text záznamu

HNF-6 Is Expressed in Endoderm Derivatives and Nervous System of the Mouse Embryo and Participates to the Cross-Regulatory Network of Liver-Enriched Transcription Factors

Autor: Jacques J. Picard, Frédéric Clotman, Frédéric P. Lemaigre, Claire Landry, Hiroaki Oda, Guy G. Rousseau, Takeshi Hioki

Publikováno v: Developmental Biology. 192:247-257

Hepatocyte nuclear factor-6 (HNF-6) is a liver-enriched transcription factor that contains a single cut domain and a novel type of homeodomain. Here we have studied the developmental expression pattern of HNF-6 in the mouse.In situhybridization exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acd78087eaaa99ce9bd2bb2feb4df1a
https://doi.org/10.1006/dbio.1997.8757

Zobrazit plný text záznamu

Crystallization and preliminary X-ray analysis of two inhibitor complexes of the catalytic domain of death-associated protein kinase

Autor: Akira Yamakawa, Hiromi Sanuki, Naoki Shibata, Yamada Kazunori, Naoko Andou, Kumiko Morita, Takeshi Hioki, Takehisa Ishii, Hideaki Ogata, Yoshiki Higuchi

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 60:764-766

The catalytic domain of death-associated protein kinase (DAPK) has been overexpressed, purified and crystallized using the sitting-drop vapour-diffusion method with PEG 8000 and magnesium acetate as precipitants. Complexes with the inhibitor staurosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8168ac5513b571093f7a3fa24eec1b3
https://doi.org/10.1107/s0907444904003014

Zobrazit plný text záznamu

[Classification of observer-groups with cluster analysis and the criteria of visual decision for each group]

Autor: Takeshi Hioki, Kuniharu Imai, Kenichi Kamegai, Takanaga Niimi, Akihiro Mano

Publikováno v: Nihon Hoshasen Gijutsu Gakkai zasshi. 59(10)

It is important that the evaluation of X-ray images include the observer's visual characteristics. However, evaluations of X-ray images that include these characteristics are not performed because of the difficulty of quantitatively elucidating visua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9669ef1ac4246ab2cbac7459a11ba2
https://pubmed.ncbi.nlm.nih.gov/14646994

Zobrazit plný text záznamu

DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells

Autor: Mutsuya, Yamamoto, Takeshi, Hioki, Takehisa, Ishii, Sadayo, Nakajima-Iijima, Shigeo, Uchino

Publikováno v: European journal of biochemistry. 269(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28d9aa040c7c87c86e19d267658d8a5c
https://pubmed.ncbi.nlm.nih.gov/11784307

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání