Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Takeshi, Chujo"'
Autor:
Jin Matsuura, Shinichiro Akichika, Fan-Yan Wei, Tsutomu Suzuki, Takahiro Yamamoto, Yuka Watanabe, Leoš Shivaya Valášek, Akitake Mukasa, Kazuhito Tomizawa, Takeshi Chujo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Human cytoplasmic tRNAs contain dihydrouridine modifications at positions 16 and 17 (D16/D17). The enzyme responsible for D16/D17 formation and its cellular roles remain elusive. Here, we identify DUS1L as the human tRNA D16/D17 writer. DUS1
Externí odkaz:
https://doaj.org/article/62cf225a3782431ea55558721a3f500c
Autor:
Yoshitaka Murakami, Fan-Yan Wei, Yoshimi Kawamura, Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kyoko Miura, Yuichi Oike, Yukio Ando, Mitsuharu Ueda, Kazuhito Tomizawa, Takeshi Chujo
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A mitochondrial tRNA modification enzyme, NSUN3, is found to be essential for embryonic development in mice, with whole-body knockout causing embryonic lethality and heart-specific Nsun3 knockout leading to heart aberration in older mice.
Externí odkaz:
https://doaj.org/article/18bce67c3ad3458da80e542465626a4f
Autor:
Kaori Oka, Shusuke Fujioka, Yoshimi Kawamura, Yoshihiro Komohara, Takeshi Chujo, Koki Sekiguchi, Yuki Yamamura, Yuki Oiwa, Natsuko Omamiuda-Ishikawa, Shohei Komaki, Yoichi Sutoh, Satoko Sakurai, Kazuhito Tomizawa, Hidemasa Bono, Atsushi Shimizu, Kimi Araki, Takuya Yamamoto, Yasuhiro Yamada, Hiroyuki Oshiumi, Kyoko Miura
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Naked mole rats are found to be resistant to cancer development through dampened inflammatory response due to genetically determined impaired necroptosis, with essential necroptosis genes RIPK3 and MLKL containing mutations causing premature stop cod
Externí odkaz:
https://doaj.org/article/9dd13d092962438287167bbbff17d001
Autor:
Yu Nagayoshi, Kayo Nishiguchi, Ryosuke Yamamura, Takeshi Chujo, Hiroyuki Oshiumi, Hiroko Nagata, Hitomi Kaneko, Keiichi Yamamoto, Hirotomo Nakata, Korin Sakakida, Akihiro Kunisawa, Masataka Adachi, Yutaka Kakizoe, Takanori Mizobe, Jun-ichi Kuratsu, Shinya Shimada, Yasushi Nakamori, Masao Matsuoka, Masashi Mukoyama, Fan-Yan Wei, Kazuhito Tomizawa
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1233 (2022)
SARS-CoV-2 infection alters cellular RNA content. Cellular RNAs are chemically modified and eventually degraded, depositing modified nucleosides into extracellular fluids such as serum and urine. Here we searched for COVID-19-specific changes in modi
Externí odkaz:
https://doaj.org/article/fd140ee4687e4b7fbff56f17a96badec
Autor:
Mayumi Hirayama, Fan-Yan Wei, Takeshi Chujo, Shinya Oki, Maya Yakita, Daiki Kobayashi, Norie Araki, Nozomu Takahashi, Ryoji Yoshida, Hideki Nakayama, Kazuhito Tomizawa
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: N6-Methyladenosine (m6A) modification is the major chemical modification in mRNA that controls fundamental biological processes, including cell proliferation. Herein, we demonstrate that fat mass and obesity-associated (FTO) demethylates m6A
Externí odkaz:
https://doaj.org/article/b31306cd90024b878954550d4a52dce1
Autor:
Junichi Iwakiri, Kumiko Tanaka, Takeshi Chujo, Hiro Takakuwa, Tomohiro Yamazaki, Goro Terai, Kiyoshi Asai, Tetsuro Hirose
Publikováno v:
RNA. 29:170-177
The mammalian cell nucleus contains dozens of membrane-less nuclear bodies that play significant roles in various aspects of gene expression. Several nuclear bodies are nucleated by specific architectural noncoding RNAs (arcRNAs) acting as structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b103ac02cb94595812aa98da3747700e
https://doi.org/10.1261/rna.079469.122
https://doi.org/10.1261/rna.079469.122
Autor:
Maya Yakita, Takeshi Chujo, Fan-Yan Wei, Mayumi Hirayama, Koji Kato, Nozomu Takahashi, Kenta Naganuma, Masashi Nagata, Kenta Kawahara, Hideki Nakayama, Kazuhito Tomizawa
Publikováno v:
RNA. 28:1013-1027
N6-isopentenyladenosine (i6A), a modified adenosine monomer, is known to induce cell death upon its addition to the culture medium. However, the molecular fate of extracellularly added i6A has yet to be identified. Here we show that i6A addition to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86e0b54cf036d491bd3a9842bae83a9d
https://doi.org/10.1261/rna.079176.122
https://doi.org/10.1261/rna.079176.122
Autor:
Sheng-Lan Shi, Hiroyuki Fukuda, Mayumi Hirayama, Kazuhito Tomizawa, Hiroyuki Oshiumi, Fan-Yan Wei, Takahiro Yamamoto, Takeshi Chujo, Taku Kaitsuka
Publikováno v:
Nucleic Acids Research
Retroviral infection requires reverse transcription, and the reverse transcriptase (RT) uses cellular tRNA as its primer. In humans, the TRMT6-TRMT61A methyltransferase complex incorporates N1-methyladenosine modification at tRNA position 58 (m1A58);
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52054e2351b7e972f44783004b184e50
https://doi.org/10.1093/nar/gkab879
https://doi.org/10.1093/nar/gkab879
Phase-separated membraneless organelles often contain RNAs that exhibit unusual semi-extractability upon the conventional RNA extraction method, and can be efficiently retrieved by needle shearing or heating during RNA extraction. Semi-extractable RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b266ca5297914ecb5e92990c4ef2410
https://doi.org/10.1101/2022.10.03.510572
https://doi.org/10.1101/2022.10.03.510572
Autor:
Dan Bar-Yaacov, Idan Frumkin, Yuka Yashiro, Takeshi Chujo, Yuma Ishigami, Yonatan Chemla, Amit Blumberg, Orr Schlesinger, Philipp Bieri, Basil Greber, Nenad Ban, Raz Zarivach, Lital Alfonta, Yitzhak Pilpel, Tsutomu Suzuki, Dan Mishmar
Publikováno v:
PLoS Biology, Vol 15, Iss 1, p e1002594 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.1002557.].
Externí odkaz:
https://doaj.org/article/d68ebf9c64a34bf3b0db2f6d2a1e4ea8