Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Takeru Hayashi"'
Autor:
Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6634 (2022)
PAR1b is a cytoplasmic serine/threonine kinase that controls cell polarity and cell–cell interaction by regulating microtubule stability while mediating cytoplasmic-to-nuclear translocation of BRCA1. PAR1b is also a cellular target of the CagA prot
Externí odkaz:
https://doaj.org/article/f0a129798c3b4030b0fd6f373ef70c31
Autor:
Kana Hashi, Chihiro Imai, Koji Yahara, Kamrunnesa Tahmina, Takeru Hayashi, Takeshi Azuma, Takako Miyabe-Nishiwaki, Hideyuki Sato, Masao Matsuoka, Sachi Niimi, Munehiro Okamoto, Masanori Hatakeyama
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Helicobacter pylori cagA-positive strains are critically involved in the development of gastric cancer. Upon delivery into gastric epithelial cells via type IV secretion, the cagA-encoded CagA interacts with and thereby perturbs the pro-onco
Externí odkaz:
https://doaj.org/article/f8666df3919444ac8c305271f76849db
Autor:
Takeru Hayashi, Miki Senda, Nobuhiro Suzuki, Hiroko Nishikawa, Chi Ben, Chao Tang, Lisa Nagase, Kaori Inoue, Toshiya Senda, Masanori Hatakeyama
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2876-2890 (2017)
Helicobacter pylori East Asian CagA is more closely associated with gastric cancer than Western CagA. Here we show that, upon tyrosine phosphorylation, the East Asian CagA-specific EPIYA-D segment binds to the N-SH2 domain of pro-oncogenic SHP2 phosp
Externí odkaz:
https://doaj.org/article/0c000b922a6440fd860b571bbe0db464
Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP1
Autor:
Christopher Takaya Knight, Masanori Hatakeyama, Atsushi Takahashi-Kanemitsu, Takeru Hayashi, Xiaojing Wu, Chi Ben
Publikováno v:
J Biol Chem
In addition to acting as a transcriptional co-activator, YAP1 directly mediates translocalization of the pro-oncogenic phosphatase SHP2 from the cytoplasm to nucleus. In the cytoplasm, SHP2 potentiates RAS–ERK signaling, which promotes cell prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b8ae43658f5bc841da165d0deb7d0f
https://doi.org/10.1074/jbc.ra120.013820
https://doi.org/10.1074/jbc.ra120.013820
Autor:
Miki Senda, Masanori Hatakeyama, Atsuo T. Sasaki, Koh Takeuchi, Takeru Hayashi, Toshiya Senda
Publikováno v:
Crystal Growth & Design. 16:1565-1571
Current X-ray sources—such as high-flux synchrotron radiation and XFEL—enable us to determine the tertiary structures of proteins at medium or low resolution even from crystals with poor quality. However, high-resolution crystal structures are st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48276b89dad585b8d1167e40cdcbccc2
https://doi.org/10.1021/acs.cgd.5b01692
https://doi.org/10.1021/acs.cgd.5b01692
Autor:
Seiichi Sato, Hideaki Higashi, Naoko Murata-Kamiya, Masanori Hatakeyama, Naomi Ohnishi, Akinori Takaoka, Shoichiro Kameoka, Takeru Hayashi, Takeshi Kameyama, Takaya Hayashi
Publikováno v:
Biomedical Research. 37:21-27
More than 50% of people in the world are infected with Helicobacter pylori (H. pylori), which induces various gastric diseases. Especially, epidemiological studies have shown that H. pylori infection is a major risk factor for gastric cancer. It has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cddd8c796c676189f86e6f2059c503d1
https://doi.org/10.2220/biomedres.37.21
https://doi.org/10.2220/biomedres.37.21
Publikováno v:
Biochemical and Biophysical Research Communications. 469:1133-1139
SHP2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that plays a key role in the proliferation of cells via RAS-ERK activation. SHP2 also promotes Wnt signaling by dephosphorylating parafibromin. Germline missense mutations of PTPN11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c79e606bb6e4c355b36463449029ac3
https://doi.org/10.1016/j.bbrc.2015.12.117
https://doi.org/10.1016/j.bbrc.2015.12.117
Publikováno v:
The Proceedings of Conference of Tokai Branch. :311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46480a7881aed5584a810c58bdd268b1
https://doi.org/10.1299/jsmetokai.2020.69.311
https://doi.org/10.1299/jsmetokai.2020.69.311
Publikováno v:
The Proceedings of Conference of Tokai Branch. :312
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11cec6a929e6d3a750e769ccd69b111c
https://doi.org/10.1299/jsmetokai.2020.69.312
https://doi.org/10.1299/jsmetokai.2020.69.312
Publikováno v:
The Proceedings of the Fluids engineering conference. 2019:OS10-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0e20498ba8c76e61fba851dab7d723d
https://doi.org/10.1299/jsmefed.2019.os10-11
https://doi.org/10.1299/jsmefed.2019.os10-11