Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Takeru, Ehara"'
3
Understanding metabolism related differences in ocular efficacy of MGV354
Autor: Ganesh Prasanna, Christopher Breen, Sean Kim, Jennifer L. Dumouchel, Christopher M. Adams, Muneto Mogi, Upendra A. Argikar, Takeru Ehara
MGV354 was being developed as a novel ocular therapy for lowering of intraocular pressure, a key modifiable risk factor for glaucoma. MGV354 is an activator of soluble guanylate cyclase, an enzyme known to be involved in the regulation of IOP. MGV354
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7f7727c2eac407f349460ea55f31ed
Zobrazit plný text záznamu
5
A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing
Autor: Christopher Towler, Malay Ghosh, Christopher M. Adams, Ronald Newton, Rebecca C. Stacy, Todd Topley, Ganesh Prasanna, Luciana Ferrara, Louis Yang, Takeru Ehara, Chuanxi Xiang, Byron Li, Muneto Mogi, Cale McAllister, Sean Kim, Dennis S Rice, Christopher Thow Hing Ng
Publikováno v: Investigative ophthalmologyvisual science. 59(5)
Purpose The nitric oxide/soluble guanylate cyclase/protein kinase G (NO/sGC/PKG) is known to be involved in the regulation of intraocular pressure (IOP) and may be dysregulated in glaucoma. The purpose is to demonstrate that the sGC activator MGV354
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f1df00433296709f3c9e00a5de99a9
https://pubmed.ncbi.nlm.nih.gov/29610853
Zobrazit plný text záznamu
6
Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors
Autor: Shimpei Kawakami, Nikolaus Schiering, Takeru Ehara, Fumiaki Yokokawa, Hiroki Gunji, Takanori Kanazawa, Kazuhide Konishi, Takatoshi Kosaka, Yuko Hitomi, Frederic Cumin, Osamu Irie, Nils Ostermann, Trixie Wagner, Philipp Grosche, Masaki Suzuki, Werner Breitenstein, Dean F. Rigel, Randy L. Webb, Atsushi Toyao, Jürgen Maibaum
Publikováno v: ACS Medicinal Chemistry Letters. 5:787-792
A cis-configured 3,5-disubstituted piperidine direct renin inhibitor, (syn,rac)-1, was discovered as a high-throughput screening hit from a target-family tailored library. Optimization of both the prime and the nonprime site residues flanking the cen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676c84f7439ee66a9dd9b3f35cd39039
https://doi.org/10.1021/ml500137b
Zobrazit plný text záznamu
7
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2
Autor: Masashi Kishida, Yuko Hitomi, Genji Iwasaki, Keiichi Masuya, Fumiaki Yokokawa, Hiroki Gunji, Yuki Iwaki, Keiko Tanabe, Takatoshi Kosaka, Hart Terance William, Atsushi Toyao, Stuart Bevan, Takeru Ehara, Marzia Malcangio, Andrew James Culshaw, Alyson Fox, Mohammed Yaqoob, Takanori Kanazawa, Naoki Teno, Kazuhide Konishi, Osamu Irie, Peter Hiestand, Hajime Hirao, Junichi Sakaki, Allan Hallett, Atsuko Iwasaki
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:5280-5284
We describe here orally active and brain-penetrant cathepsin S selective inhibitors, which are virtually devoid of hERG K(+) channel affinity, yet exhibit nanomolar potency against cathepsin S and over 100-fold selectivity to cathepsin L. The new non
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8439439159fed7e2b80822ff5034fc15
https://doi.org/10.1016/j.bmcl.2008.08.067
Zobrazit plný text záznamu
8
Effect of Cathepsin K Inhibitors on Bone Resorption
Autor: Motohiko Kometani, Ichiro Umemura, Naoko Matsuura, Ikuo Sugiyama, Yuko Hitomi, Takeru Ehara, Takatoshi Kosaka, Keiichi Masuya, Naoki Teno, Genji Iwasaki, Noriko Uchiyama, Kazuhiro Toriyama, Osamu Irie, Takahiro Miyake, Hiroaki Fukaya, Kazuhiko Nonomura
Publikováno v: Journal of Medicinal Chemistry. 51:5459-5462
On the basis of the pyrrolopyrimidine core structure that was previously discovered, cathepsin K inhibitors having a spiro amine at the P3 have been explored to enhance the target, bone marrow, tissue distribution. Several spiro structures were ident
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdb3283586e240e5700f0f269569870
https://doi.org/10.1021/jm800626a
Zobrazit plný text záznamu
10
One-pot synthesis of 2-aminobenzimidazoles using 2-chloro-1,3-dimethylimidazolinium chloride (DMC)
Autor: Jonathan P. van Dyck, Miller Bridget R, Brian Diaz, Catherine Solovay, Poon Daniel J, Nan Ji, Takeru Ehara, Stillwell Brady S, Christopher M. Adams, Siesel David A, Gu Danlin, David M. Ryckman, Donglei Liu, Chun Zhang, Martin Dimitroff, Pick Teresa E, Gerald D. Artman, Fupeng Ma, Swiftney Tyson
Publikováno v: Tetrahedron Letters. 51:5319-5321
2-Chloro-1,3-dimethylimidazolinium chloride (DMC or DMC-Cl) has been found to effectively and rapidly generate 2-aminobenzimidazoles from 1,2-diaminoarenes and isothiocyanates in moderate to good yields at room temperature in a one-pot operation.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::634dfa9658f671c941424273b12b27b0
https://doi.org/10.1016/j.tetlet.2010.07.177
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje