Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Takeo Shimo"'
Publikováno v:
Drug and Chemical Toxicology. 34:192-198
To clarify the toxicological aspects of crystal-mediated nephrotoxicity, we performed analysis concerning the correlation between representative kidney-related parameters and renal histopathology, using the individual data obtained from the 4-week to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b023f32b468b96d0f7f5c865f4e5bdcd
https://doi.org/10.3109/01480545.2010.500291
https://doi.org/10.3109/01480545.2010.500291
Autor:
Osamu Nagata, Takeo Shimo, Takako Igarashi, Takashi Nakazawa, Noriko Chikamatsu, Masaharu Yamamoto
Publikováno v:
Archives of Toxicology. 80:442-448
To investigate the mechanism on photosensitive dermatitis caused by ketoprofen (KP) in humans, the following experiments were performed by topical application on guinea pigs. The phototoxicity study involving treatment with 10% solution of KP, its en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a5ad155832dba7b3ed931dac6c40a5
https://doi.org/10.1007/s00204-006-0063-7
https://doi.org/10.1007/s00204-006-0063-7
Publikováno v:
Toxicological Sciences. 87:267-276
The possible mechanism of the underlying nephropathy found in the rat toxicity study of FYX-051, a xanthine oxidoreductase inhibitor, was investigated. Rats received oral treatment of either 1 or 3 mg/kg of FYX-051, with and without citrate for four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4555c1824525f0eac785ea6614bdff72
https://doi.org/10.1093/toxsci/kfi210
https://doi.org/10.1093/toxsci/kfi210
Autor:
Akemi Saito, Yasuji Aoki, Eisuke Morohashi, Yasuhiro Tega, Takeo Shimo, Junichi Katayama, Osamu Nagata
Publikováno v:
Journal of Toxicologic Pathology. 14:1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fe60cb675db9d20e917a0d6cfe20cc
https://doi.org/10.1293/tox.14.1
https://doi.org/10.1293/tox.14.1
Autor:
Masao Hirose, Hiroshi Onodera, Toru Tamura, Yasuji Aoki, Hisayoshi Takagi, Kunitoshi Mitsumori, Osamu Nagata, Kazuo Yasuhara, Takeo Shimo
Publikováno v:
Toxicological Sciences. 58:43-49
It is unknown whether endocrine-disrupting chemicals (EDCs) with estrogenic activities have any modifying effects on uterine carcinogenesis. In our previous study, we established a uterine-carcinogenesis model that is useful for detecting tumor-modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450bb1c95a7535a305a39a5e3d13674b
https://doi.org/10.1093/toxsci/58.1.43
https://doi.org/10.1093/toxsci/58.1.43
Autor:
Chika Maruyama, Kazuo Yasuhara, Takatoshi Koujitani, Hiroshi Onodera, Masao Hirose, Kunitoshi Mitsumori, Takeo Shimo, Hisayoshi Takagi, Shigeharu Wakana
Publikováno v:
Carcinogenesis. 21:1039-1042
To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53( +/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b73e656042226580dcde3fb2e36d34
https://doi.org/10.1093/carcin/21.5.1039
https://doi.org/10.1093/carcin/21.5.1039
Publikováno v:
Journal of Toxicologic Pathology. 13:123-126
A hematopoietic neoplasm was found in a 14-week-old male Sprague-Dawley (SD) rat. Blood smear examination revealed the existence of numerous blastic cells with large, round or oval nuclei, and scant pale cytoplasm containing no granules. At autopsy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9df059ea5ce90d93c13892a4cd7a135
https://doi.org/10.1293/tox.13.123
https://doi.org/10.1293/tox.13.123
Autor:
Hiroshi Onodera, Takeo Shimo, Kiyoshi Takegawa, Keisuke Kitaura, Kunitoshi Mitsumori, Michihito Takahashi, Kazuo Yasuhara
Publikováno v:
Japanese Journal of Cancer Research : Gann
In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c757ccf5aa93b391e045b3f15de611cf
https://doi.org/10.1111/j.1349-7006.1998.tb00536.x
https://doi.org/10.1111/j.1349-7006.1998.tb00536.x
Autor:
Masafumi Ohshita, Takeo Shimo, Junichi Katayama, Eiichi Okezaki, Yasuji Aoki, Osamu Nagata, Akemi Saito
Publikováno v:
Journal of Toxicologic Pathology. 11:229-234
To elucidate the possible pathomechanism of glomerulosclerosis by partial nephrectomy, male SD rats received 3/4 nephrectomy and were maintained without further treatment for 8 weeks (3/4 nephrectomized group). Another group received a sham operation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eb426ef585d82b5736f59af052b45a9
https://doi.org/10.1293/tox.11.229
https://doi.org/10.1293/tox.11.229
Autor:
Takeo Shimo, Kunitoshi Mitsumori, Masakazu Takahashi, Junichi Katayama, Akemi Saito, Hidenobu Yoshida, Yasuji Aoki, Hiroshi Onodera, Michihito Takahashi
Publikováno v:
Europe PubMed Central
To clarify relationships between serum thyroid-stimulating hormone (TSH) levels and ultrastructural changes in thyrotrophs caused by intermittent or continuous treatments with antithyroid compound, male Fischer-344 rats initiated with N-bis(2-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cacea747775201ffab17af580a3a8e
https://doi.org/10.1177/019262339702500207
https://doi.org/10.1177/019262339702500207