Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Takeo Shimasaki"'
Autor:
Kagenori Ito, Tomofumi Yamamoto, Yusuke Hayashi, Shun Sato, Jun Nakayama, Fumihiko Urabe, Takeo Shimasaki, Eijiro Nakamura, Yoshiyuki Matui, Hiroyuki Fujimoto, Takahiro Kimura, Shin Egawa, Takahiro Ochiya, Yusuke Yamamoto
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2147-2167 (2023)
Clinically, the osteolytic phenotype is rare in prostate cancer (PCa), and the prognosis is generally worse than that of the osteoblastic phenotype. Osteoblastic prostate cancer (BPCa) is a major type of bone metastasis. Several factors responsible f
Externí odkaz:
https://doaj.org/article/552f86d13f2e40149574c3164a08091a
Autor:
Naoko Sakurai, Tomoyuki Shibata, Masakatsu Nakamura, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Ostuka, Tomomitsu Tahara, Tomiyasu Arisawa
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background CDKN2A hypermethylation is among the major events associated with carcinogenesis and is also observed in non-neoplastic colonic mucosa in patients with ulcerative colitis (UC). Macrophage migration inhibitory factor (MIF) plays a
Externí odkaz:
https://doaj.org/article/bb555cb28c244a6694ed3c7c174e6d3b
Autor:
Hikaru Takano, Tomoyuki Shibata, Masakatsu Nakamura, Naoko Sakurai, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Otsuka, Tomomitsu Tahara, Tomiyasu Arisawa
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background CpG methylation of tumor suppressor genes occurs in the early stage of carcinogenesis. Detecting risk factors for aberrant CpG methylation is clinically important for predicting cancer development. DNA methyltransferase (DNMT) 3a
Externí odkaz:
https://doaj.org/article/c552e4dfc8404b57be791a7b26ed0f94
Autor:
Yasuto Yamamoto, Takeo Shimasaki, Yasuhito Ishigaki, Shino Fujimoto, Yoshimitsu Takahashi, Shiori Kimura, Keiko Aijo, Mami Takayanagi, Shuichi Mizuta, Togen Masauji, Yasufumi Masaki
Publikováno v:
Medicina, Vol 58, Iss 6, p 733 (2022)
Recent advances in chemotherapy have led to the emergence of new types of anticancer agents. With these advances, cases of side effects that have not been witnessed in the past have emerged. The systems of side effect evaluation and their grading hav
Externí odkaz:
https://doaj.org/article/3c5326d35485487aa10247d036394516
Autor:
Takeo Shimasaki, Satoko Yamamoto, Risa Omura, Kagenori Ito, Yumiko Nishide, Hideki Yamada, Kazumi Ohtomo, Tomo Ishisaka, Keiichiro Okano, Takenori Ogawa, Hiroyuki Tsuji, Yoichi Matsuo, Toshinari Minamoto, Naohisa Tomosugi, Etienne Ferain, Takahiro Ochiya
Publikováno v:
Micromachines, Vol 12, Iss 11, p 1431 (2021)
Microfluidics is applied in biotechnology research via the creation of microfluidic channels and reaction vessels. Filters are considered to be able to simulate microfluidics. A typical example is the cell culture insert, which comprises two vessels
Externí odkaz:
https://doaj.org/article/3db5e14965d9480aa9c15f4763df7c82
Autor:
Toshinari Minamoto, Kazuyuki Kawakami, Hideo Nakajima, Takeo Shimasaki, Yasuhito Ishigaki, Yoshiharu Motoo
Publikováno v:
Cancers, Vol 3, Iss 1, Pp 446-460 (2011)
Pancreatic cancer develops and progresses through complex, cumulative biological processes involving metabolic disorder, local inflammation, and deregulated molecular pathways. The resulting tumor aggressiveness hampers surgical intervention and rend
Externí odkaz:
https://doaj.org/article/1185492e305c4d2ea9de7d70d44947c0
Autor:
Ayako Kitano, Takeo Shimasaki, Yuri Chikano, Mitsutoshi Nakada, Mayumi Hirose, Tomomi Higashi, Yasuhito Ishigaki, Yoshio Endo, Takahisa Takino, Hiroshi Sato, Yoshimichi Sai, Ken-Ichi Miyamoto, Yoshiharu Motoo, Kazuyuki Kawakami, Toshinari Minamoto
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55289 (2013)
The major obstacles to treatment of pancreatic cancer are the highly invasive capacity and resistance to chemo- and radiotherapy. Glycogen synthase kinase 3β (GSK3β) regulates multiple cellular pathways and is implicated in various diseases includi
Externí odkaz:
https://doaj.org/article/7a4aacd7bd564a35bf16a75151dc2583
Autor:
Toshinari Minamoto, Yoshiharu Motoo, Takeo Shimasaki, Mingji Jin, Kenji Yokoi, Katsuyoshi Miyashita, Satoru Kyo, Abbas Shakoori, Kazuyuki Kawakami, Wei Mai
Supplementary Data from Deregulated GSK3 Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6335b3756b4ed9dd9a455f4352948a34
https://doi.org/10.1158/1078-0432.22440633.v1
https://doi.org/10.1158/1078-0432.22440633.v1
Autor:
Toshinari Minamoto, Yoshiharu Motoo, Takeo Shimasaki, Mingji Jin, Kenji Yokoi, Katsuyoshi Miyashita, Satoru Kyo, Abbas Shakoori, Kazuyuki Kawakami, Wei Mai
Purpose: Glycogen synthase kinase-3 (GSK3) regulates multiple cell signaling pathways and has been implicated in glucose intolerance, neurodegenerative disorders, and inflammation. We investigated the expression, activity, and putative pathologic rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763e4bdfb1d3f3424c33b7402b045da3
https://doi.org/10.1158/1078-0432.c.6517935.v1
https://doi.org/10.1158/1078-0432.c.6517935.v1
Autor:
Tomiyasu Arisawa, Masafumi Ota, Tomoyuki Shibata, Ranji Hayashi, Tasuku Hayashi, Masakatsu Nakamura, Naoko Sakurai, Tomoe Nomura-Horita, Hikaru Takano, Tomomitsu Tahara, Toshimi Ostuka, Takeo Shimasaki
Publikováno v:
Genetic Testing and Molecular Biomarkers. 25:255-262
Objective: This study was designed to clarify the association of the MAFK polymorphisms (rs4268033, rs3735656, and rs10226620) with the degree of gastric mucosal atrophy and CDKN2A CpG methylation ...