Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Takeo Kubota"'
Autor:
Musashi Kawamura, Naoki Goda, Natsuyo Hariya, Mayu Kimura, Shiori Ishiyama, Takeo Kubota, Kazuki Mochizuki
Publikováno v:
Biochemistry and Biophysics Reports, Vol 29, Iss , Pp 101196- (2022)
Background: The expressions of genes related to lipid metabolism are decreased in adipocytes with insulin resistance. In this study, we examined the effects of fatty acids on the reduced expressions and histone acetylation of lipid metabolism-related
Externí odkaz:
https://doaj.org/article/9fd0453fd3444a699fa0adb7825fa65f
Autor:
Ryu Miura, Atsuko Araki, Machiko Minatoya, Kunio Miyake, Mei-Lien Chen, Sumitaka Kobayashi, Chihiro Miyashita, Jun Yamamoto, Toru Matsumura, Mayumi Ishizuka, Takeo Kubota, Reiko Kishi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposu
Externí odkaz:
https://doaj.org/article/3ad00696fdee40eaab97f5fac482ae17
Autor:
Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Naohiko Tanabe, Wataru Kikushima, Fumihiko Mabuchi, Atsuki Kume, Takeo Kubota, Hiroyuki Iijima
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149978 (2016)
To investigate the prevalence and genetic characteristics of geographic atrophy (GA) among elderly Japanese with advanced age-related macular degeneration (AMD) in a clinic-based study.Two-hundred and ninety consecutive patients with advanced AMD wer
Externí odkaz:
https://doaj.org/article/e5ad1b4466bf4b3a874ef6c96d8489cd
Publikováno v:
Pharmaceuticals, Vol 5, Iss 4, Pp 369-383 (2012)
The number of children with mild neurodevelopmental disorders, such as autism, has been recently increasing in advanced countries. This increase is probably caused by environmental factors rather than genetic factors, because it is unlikely that gene
Externí odkaz:
https://doaj.org/article/bcf3dcc0ed414573bfccd64b873aa06b
Autor:
Takeo Kubota
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2720 (2018)
Epigenetics is a gene regulation mechanism that does not depend on genomic DNA sequences, but depends instead on chemical modifications of DNA and histone proteins. [...]
Externí odkaz:
https://doaj.org/article/5abc4aeb785645f2965639261d31e184
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 1, Pp 3-8 (2010)
Epigenetics is a mechanism that regulates gene expression not depending on the underlying DNA sequence, but on the chemical modifications of DNA and histone proteins. Defects in the factors involved in epigenetic regulation cause congenital neurodeve
Externí odkaz:
https://doaj.org/article/fc98781be7fb4837b60a720c24e6c968
Autor:
Peter E. Thijssen, Yuya Ito, Giacomo Grillo, Jun Wang, Guillaume Velasco, Hirohisa Nitta, Motoko Unoki, Minako Yoshihara, Mikita Suyama, Yu Sun, Richard J. L. F. Lemmers, Jessica C. de Greef, Andrew Gennery, Paolo Picco, Barbara Kloeckener-Gruissem, Tayfun Güngör, Ismail Reisli, Capucine Picard, Kamila Kebaili, Bertrand Roquelaure, Tsuyako Iwai, Ikuko Kondo, Takeo Kubota, Monique M. van Ostaijen-Ten Dam, Maarten J. D. van Tol, Corry Weemaes, Claire Francastel, Silvère M. van der Maarel, Hiroyuki Sasaki
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-2 (2016)
Nature Communications 6: Article number: 7870 (2015); Published: 28 July 2015; Updated: 22 June 2016 In Fig. 1b of this Article, the sex of patient 2.1 in family A is incorrect, and should be depicted as male. The correct version of this figure appea
Externí odkaz:
https://doaj.org/article/39037390f270467296e8d2c54de0aed6
Autor:
Oh-oka Kyoko, Hiroshi Kono, Kayoko Ishimaru, Kunio Miyake, Takeo Kubota, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Atsuhito Nakao
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98016 (2014)
BACKGROUND & AIMS: The circadian clock drives daily rhythms in behavior and physiology. A recent study suggests that intestinal permeability is also under control of the circadian clock. However, the precise mechanisms remain largely unknown. Because
Externí odkaz:
https://doaj.org/article/03e6d535ccc24ae7b78a91e9664407a8
Autor:
Kunio Miyake, Chunshu Yang, Yohei Minakuchi, Kenta Ohori, Masaki Soutome, Takae Hirasawa, Yasuhiro Kazuki, Noboru Adachi, Seiko Suzuki, Masayuki Itoh, Yu-Ichi Goto, Tomoko Andoh, Hiroshi Kurosawa, Mitsuo Oshimura, Masayuki Sasaki, Atsushi Toyoda, Takeo Kubota
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66729 (2013)
Monozygotic (identical) twins have been widely used in genetic studies to determine the relative contributions of heredity and the environment in human diseases. Discordance in disease manifestation between affected monozygotic twins has been attribu
Externí odkaz:
https://doaj.org/article/9050d526d07243489bf95e66c5b60318
Publikováno v:
Diseases, Vol 4, Iss 1, p 15 (2016)
Prader-Willi syndrome (PWS) is a congenital neurodevelopmental disorder caused by loss of function of paternally expressed genes on chromosome 15 due to paternal deletion of 15q11–q13, maternal uniparental disomy for chromosome 15, or an imprinting
Externí odkaz:
https://doaj.org/article/b9f54e17d26f4b68b500674de297e9de