Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Takenori Ishimaru"'
1
Potent NK1 Receptor Antagonists: Synthesis and Antagonistic Activity of Various Heterocycles with an N-(3,5-Bis(trifluoromethyl)benzyl)-N-methylcarbamoyl Substituent
Autor: Takayuki Doi, Takenori Ishimaru, Kiyota Y, Toshimasa Tanaka, Masaki Ogino, Yoshinori Ikeura, Izumi Kamo, Hideaki Natsugari, Shinji Morimoto
Publikováno v: Chemical and Pharmaceutical Bulletin. 45:1642-1652
Various N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl heterocycles (1, 2 and 3) modified at rings A and B in the isoquinolone (1a) and pyrido[3,4-b]pyridine (2a) nuclei were prepared and evaluated for NK 1 receptor antagonistic activities. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4809642e2b5e5d695054878e37c9b061
https://doi.org/10.1248/cpb.45.1642
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2
Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyrido[3,4-b]pyridine
Autor: Izumi Kamo, Takayuki Doi, O. Saga, Toshimasa Tanaka, Yutaka Kiyota, Hideo Shirafuji, Hideaki Natsugari, Takenori Ishimaru, Yuji Ishichi, Yoshinori Ikeura
Publikováno v: Journal of Medicinal Chemistry. 38:3106-3120
A series of 4-phenylisoquinolone derivatives were synthesized and evaluated for NK1 (substance P) antagonist activity. Highly potent antagonists, 4-phenyl-3-isoquinolone-N-benzylcarboxamides (11), were discovered from the structure-activity relations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98325c42e302de564455962217cc12fc
https://doi.org/10.1021/jm00016a014
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4
ChemInform Abstract: Potent NK1 Receptor Antagonists: Synthesis and Antagonistic Activity of Various Heterocycles with an N-[3,5-Bis(trifluoromethyl)benzyl]-N-methylcarbamoyl Substituent
Autor: Yoshinori Ikeura, Kiyota Y, Masaki Ogino, Toshimasa Tanaka, Takenori Ishimaru, Izumi Kamo, Takayuki Doi, Hideaki Natsugari, Shinji Morimoto
Publikováno v: ChemInform. 29
Various N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl heterocycles (1, 2 and 3) modified at rings A and B in the isoquinolone (1a) and pyrido[3,4-b]pyridine (2a) nuclei were prepared and evaluated for NK 1 receptor antagonistic activities. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::319a465657ad10565ba1923385c16474
https://doi.org/10.1002/chin.199812247
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6
Effects of TAK-637, a tachykinin receptor antagonist, on lower urinary tract function in the guinea pig
Autor: Izumi Kamo, Yoshinori Ikeura, Takenori Ishimaru, Hideaki Natsugari, Takayuki Doi, Satoshi Okanishi, Shigemitsu Imai
Publikováno v: European journal of pharmacology. 383(3)
The effects of TAK-637 ((aR,9R)-7-[3,5-bis(trifluoromethyl)benzyl]-8, 9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H-[1,4]diazocino[2 , 1-g][1,7]naphthyridine-6,13-dione), a novel tachykinin NK(1) receptor antagonist, on the micturition reflex in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473b85c82900d21bd57403c3062e89b7
https://pubmed.ncbi.nlm.nih.gov/10594323
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7
Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK(1) receptor antagonists: synthesis, antagonistic activity, and effects on bladder functions
Autor: Akira Fujishima, Yoshinori Ikeura, Izumi Kamo, Hideaki Natsugari, Toshimasa Tanaka, Takayuki Doi, Mitsuru Kawada, Yuji Ishichi, Fumiko Kasahara, Takenori Ishimaru
Publikováno v: Journal of medicinal chemistry. 42(19)
Cyclic analogues of N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-N, 7-dimethyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide (1) having a 6-9-membered ring (6-9) were synthesized and evaluated for NK(1) antagonistic activities. The 8-mem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c914f9c41c5e5d8bcbd8caac65f87310
https://pubmed.ncbi.nlm.nih.gov/10508446
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8
TAN-931, a novel nonsteroidal aromatase inhibitor produced by Penicillium funiculosum No. 8974. I. Taxonomy, fermentation, isolation,characterization and biological activities
Autor: Takenori Ishimaru, Katsuichi Sudo, Tsuneaki Hida, Masayuki Muroi, Takafumi Ishii, Shigemi Iinuma, Tsuneo Kanamaru, Hisayoshi Okazaki
Publikováno v: The Journal of antibiotics. 44(6)
A novel nonsteroidal aromatase inhibitor, TAN-931, was isolated from the culture filtrate of a soil isolate fungus, No. 8974. The strain was identified as Penicillium funiculosum No. 8974. TAN-931 inhibited human placental and rat ovarian aromatase a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5856b275cb2d059a6f83450951808d
https://pubmed.ncbi.nlm.nih.gov/2071487
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