Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Takemi Sakamoto"'
Publikováno v:
Materials Science Forum. 792:104-109
An NDE measurement for internal defects of metal casting products is presented. The internal defects are often made in the manufacturing process of metal casting. From the view point of non-destructive evaluation (NDE), it is very difficult to make a
Autor:
Hiroshi Fukui, Takemi Sakamoto, Hirotsugu Okuda, Masaji Kikukawa, Shigeki Kuriyama, Craig A. Mullen, Kazuhiro Masui, Toshiya Nakatani, Hitoshi Yoshiji, Tadasu Tsujii, Kazuhiro Ikenaka
Publikováno v:
International Journal of Cancer. 81:592-597
Murine hepatocellular carcinoma cells were retrovirally transduced with the bacterial cytosine deaminase (CD) gene. CD-transduced cells exhibited more than 120-fold higher sensitivity to 5-fluorocytosine (5-FC) compared with parental cells. When syng
Autor:
Toshiya Nakatani, Masaji Kikukawa, Takemi Sakamoto, Shigeki Kuriyama, Y. Toyokawa, Hiroshi Fukui, Kazuhiro Ikenaka, Hirohisa Tsujinoue, Tadasu Tsujii
Publikováno v:
Gene Therapy. 5:1299-1305
Although expression of transgenes under the control of a retroviral long terminal repeat (LTR) promoter has been shown not to persist due to methylation, it has been observed that internal promoter may be active even if expression from the LTR promot
Autor:
Shigeki Kuriyama, Ping Du, Zhong-Tian Qi, Guangwen Cao, Kazuhiro Masui, Xian-Tao Kong, Takemi Sakamoto
Publikováno v:
Gastroenterology. 112:501-510
BACKGROUND & AIMS: Although tumor necrosis factor (TNF)-alpha possesses a potent antitumor activity, systemic administration of TNF-alpha causes severe side effects. To circumvent this, the efficacy of tumor cell-targeted TNF-alpha gene therapy was i
Autor:
Kazuhiro Ikenaka, Shigeki Kuriyama, Tadasu Tsujii, Takemi Sakamoto, Craig A. Mullen, K Tominaga, Toshiya Nakatani, Kazuhiro Masui, Hiroshi Fukui
Publikováno v:
International Hepatology Communications. 4:72-79
One of the most promising approaches to the treatment of cancer is to render tumor cells susceptible to normally non-toxic chemotherapeutic agents utilizing so-called ‘suicide genes’. The herpes simplex virus thymidine kinase gene is a prototypic
Autor:
Dai Nakae, Hiroshi Fukui, Masahide Yoshikawa, Takemi Sakamoto, Hitoshi Yoshiji, Masami Matsumoto, Kazuhiro Masui, Shigeki Kuriyama, Yukari Morimoto, Tadasu Tsujii, Hiroshige Nakano, Masayoshi Ueno, Yoichi Konishi, Hideyuki Kojima
Publikováno v:
Journal of Gastroenterology. 30:248-253
A case of early gastric malignant lymphoma definitively diagnosed by strip biopsy is reported. The subsequent operation revealed that the strip biopsy had resulted in radical resection. A 55-year-old woman visited our hospital for detailed examinatio
Autor:
Takemi Sakamoto, Kentaro Tominaga, Shigeki Kuriyama, Hiroshi Fukui, Tadasu Tsujii, Kazuhiro Ikenaka, Masahide Yoshikawa, Toshiya Nakatani
Publikováno v:
International Hepatology Communications. 1:253-259
We previously demonstrated that a foreign gene transferred by means of a retroviral vector can be expressed selectively in hepatoma cells when a liver-specific promoter was used to direct its expression. We now describe an approach for the treatment
Autor:
Yoshitsugu Yoshikawa, Kouji Yamamoto, Mayumi Mimura, Tadasu Tsujii, Eiryou Kikuchi, Tadao Mochi, Masahide Yoshikawa, Junichi Yamao, Takemi Sakamoto, Akira Shiroi, Hiroshi Fukui, Akira Mitoro
Publikováno v:
Internal Medicine. 32:327-331
We report a 34-year-old man with chronic hepatitis C who showed exacerbation of ulcerative colitis during alpha-interferon (IFNα) therapy. Discontinuance of the IFNα therapy improved his symptoms, suggesting that IFNα administration might worsen u
Autor:
Hirohisa Tsujinoue, S Nagao, Takemi Sakamoto, Toshiya Nakatani, Kazuhiro Masui, Shigeki Kuriyama, Hitoshi Yoshiji, Masaji Kikukawa, Kazuhiro Ikenaka, Hiroshi Fukui, Tadanori Yoshimatsu, Masaharu Yamazaki
Publikováno v:
Gene therapy. 6(4)
Although xenotransplantation of retrovirus-producing cells into a tumor has been shown to be effective for the treatment of cancer, injections of recombinant retroviruses are much more feasible for clinical applications. We established a clone produc
Autor:
Tadasu Tsujii, Kentaro Tominaga, Kazuhiro Ikenaka, Kazuhiro Masui, Toshiya Nakatani, Takemi Sakamoto, Masaji Kikukawa, Shigeki Kuriyama, Hiroshi Fukui, Masahide Yoshikawa
Publikováno v:
International journal of cancer. 71(3)
The efficacy of expression of the herpes simplex virus thymidine kinase (HSV-tk) gene under the transcriptional control of the liver-specific albumin gene promoter, followed by ganciclovir treatment, was investigated both in vitro and in vivo. Murine