Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Takemi Fukuda"'
Autor:
Takemi Fukuda, Keiichiro Haga, Yukiko Takahashi, Takashi Futamura, Yoshitaka Ohashi, Kazuhiro Yano
Publikováno v:
Folia Pharmacologica Japonica. 107:247-253
The affinities of mosapramine hydrochloride, an iminodibenzyl antipsychotic drug, for dopamine receptor subtypes were determined by human dopamine D2, D3 and D4 receptors expressed in several cell lines and compared with those of other neuroleptics.
Publikováno v:
Folia Pharmacologica Japonica. 105:461-468
The affinity of cisapride for 5-HT4 receptors was investigated in comparison with those of other 5-HT4 receptor agonists and antagonists, such as 5-HT, 5-MeOT, mosapride, zacopride, metoclopramide, BIMU8, GR113808, SDZ 205-557 and ICS 205-930. Cisapr
Publikováno v:
Folia Pharmacologica Japonica. 106:339-346
The affinity of mosapramine, an iminodibenzyl antipsychotic, to dopamine D3-receptors in rat brain was investigated by quantitative autoradiography of [3H]-7-OH-DPAT, a selective D3-ligand. Autoradiograms showed restricted distribution of [3H]7-OH-DP
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:1074-1078
Mosapramine (1) is a new neuroleptic drug with an asymmetric carbon atom (8a) in its imidazopyridine ring. The enantiomers of this agent were synthesized to compare their biological activities, such as antiapomorphine activity, affinity for dopamine
Autor:
Takanobu Kuroita, Mitsuharu Sano, Ken-ichi Inaba, Mitsuyoshi Yasumoto, Takemi Fukuda, Tetsuya Tahara, Takeshi Kawakita
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:624-630
A series of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity assessed by their ability to antagonize the von Bezold-Jarish (BJ) effect in rats. Derivative
Publikováno v:
YAKUGAKU ZASSHI. 112:615-621
Four phenolic metabolites of (+-)-3-chloro-5-[3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo[1,2- a]pyridine-3-spiro-4'-piperidino)propyl]-10,11-dihydro-5H-dibenz [b,f]azepine (mosapramine), a new antipsychotic drug, were synthesized in order to determin
Publikováno v:
Microvascular research. 76(2)
To elucidate the cellular localization of Phosphoglycerate mutase (PGAM1) type B in the brain and periphery, immunocytochemical studies were performed. The purified antigen used to generate the antiserum to PGAM1 was run on an SDS-PAGE gel, stained w
Autor:
Nobuhiro Marubayashi, Kiyoharu Hayano, Kuniki Ikeda, Michihide Setoguchi, Tetsuya Tahara, Takemi Fukuda, Shu Murakami
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:1609-1615
A series of 2,3-dihydrobenzofuran-7-carboxamides, presenting a stabilized intramolecular hydrogen bond, was synthesized and evaluated in pharmacological models for antipsychotic activity. Among them, N-[(1-butyl-2-pyrrolidinyl)methyl]-2-methyl-5-sulf
Publikováno v:
Folia Pharmacologica Japonica. 96:65-71
The effect of Y-516 on the hyperactivity induced by dopamine injected bilaterally into the nucleus accumbens was compared with those of clocapramine (CCP), haloperidol (HPD) and chlorpromazine (CPZ). Dopamine (5-50 micrograms) injected into the nucle
Publikováno v:
Obesity research. 3
The function of serotonin (5-HT)3 receptors on colonic transit was investigated in unanesthetized rats. The colonic transit was accelerated by 5-HT (10 mg/kg, s.c.), 2-methyl-5-HT (30 mg/kg, s.c.), neostigmine (0.03-0.1 mg/kg, s.c.), corticotropin re