Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Takeji Shibatani"'
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 10:141-149
A lipase from Serratia marcescens was selected as an asymmetric hydrolytic enzyme for trans-3-(4-methoxyphenyl)glycidic acid methyl ester [(±)-MPGM], a key intermediate in the synthesis of diltiazem hydrochloride that is useful as a coronary vasodil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a214c1e842d33c436cb0259cace58d6c
https://doi.org/10.1016/s1381-1177(00)00122-3
https://doi.org/10.1016/s1381-1177(00)00122-3
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:146-150
An effective new route to diltiazem, a representative coronary vasodilator, through (-)-(2R, 3S)-3-(4-methoxyphenyl)glycidamide [(-)-2] has been achieved. The glycidamide (-)-2 was prepared in 43% overall yield by a combination of the enzymatic resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f51de86ef6ec4726998a1ea102e0028f
https://doi.org/10.1248/cpb.47.146
https://doi.org/10.1248/cpb.47.146
Publikováno v:
Applied Microbiology and Biotechnology. 47:347-351
In order to develop a practical process for D-lysine production from L-lysine, successive chemical racemization and microbial asymmetric degradation were investigated. The racemization of L-lysine proceeded quantitatively at elevated temperatures. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a51e90fc13c9a23e619d09019cd1e3
https://doi.org/10.1007/s002530050938
https://doi.org/10.1007/s002530050938
Publikováno v:
Applied Microbiology and Biotechnology. 47:173-179
The microbial degradation of l-methionine was investigated in order to develop a practical process for d-methionine production from racemic methionines. Among the 1000 culture strains tested, microorganisms belonging to the Achromobacter, Bacillus, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d854516d76615265801ba0efaec696db
https://doi.org/10.1007/s002530050908
https://doi.org/10.1007/s002530050908
Publikováno v:
Biotechnology Letters. 19:245-250
In order to develop an industrial production process of D-lysine from L-lysine, successive chemical racemization and a microbial asymmetric degradation were investigated in a pilot scale. The racemization of L-lysine proceeded quantitatively. The cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf5c6fa20b6114f772234af003b1182
https://doi.org/10.1023/a:1018357607976
https://doi.org/10.1023/a:1018357607976
Publikováno v:
Journal of Fermentation and Bioengineering. 84:195-199
Bakers' yeast-mediated reduction of (RS)-2-(4-methoxyphenyl)-1,5-benzothiazepin-3,4(2H,5H)-dione [(RS)-1] to (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzo-thiazepin-4(5H)-one, a key intermediate in the synthesis of diltiazem hydrochlori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc780fd1b551d3efbfd45749573f7ef
https://doi.org/10.1016/s0922-338x(97)82054-5
https://doi.org/10.1016/s0922-338x(97)82054-5
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:1922-1927
Practical preparation methods of an optically active intermediate of diltiazem, (+)-(2S, 3S)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1, 5-benzothiazepin-4(5H)-one [(+)-7], have been developed by the use of physicochemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9771db87618513ea1299f18c53f4d7
https://doi.org/10.1248/cpb.45.1922
https://doi.org/10.1248/cpb.45.1922
Publikováno v:
Applied Biochemistry and Biotechnology. 59:319-328
An emulsion bioreactor for production of (2R,3S)-3-(4-methoxyphenyl) glycidic acid methyl ester ([-]MPGM) from a racemic mixture ([±]MPGM) using the lipase fromSerratia marcescens has been proposed. Kinetics of hydrolyzing reaction and purification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e13bef6cba928ff51da715934136add5
https://doi.org/10.1007/bf02783573
https://doi.org/10.1007/bf02783573
Autor:
Ikuko Machida, Shinichi Yamada, Takeji Shibatani, Yasuhiko Ozaki, Takuo Noshida, Hiroaki Matsumae
Publikováno v:
Journal of Fermentation and Bioengineering. 81:534-537
Microbial production of (2 S ,3 S )-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5 H )-one [(2 S ,3 S )-DHMB], a key intermediate in the synthesis of diltiazem hydrochloride, was investigated. In the course of the screening of micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6363fd3ba07ef502baa2afc3483c76c3
https://doi.org/10.1016/0922-338x(96)81475-9
https://doi.org/10.1016/0922-338x(96)81475-9
Publikováno v:
Journal of Fermentation and Bioengineering. 81:21-25
The combination of a membrane bioreactor using lipase from Serratia marcescens and a crystallizer has been proposed for the production of optically active ( 2R, 3S )-3-(4-methoxyphenyl) glycidic acid methyl ester ((−)MPGM) from racemic compounds ((
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c56f4ea105542a909a5a549c3f80692
https://doi.org/10.1016/0922-338x(96)83114-x
https://doi.org/10.1016/0922-338x(96)83114-x