Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Takehito Okui"'
Autor:
Takehito Okui, Shiori Kuraoka, Masaya Iwashita, Rei Itagawa, Taku Kasai, Masanori Aikawa, Sasha A. Singh, Elena Aikawa
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Introduction: Carnitine O-octanoyltransferase (CROT) is a well-established peroxisomal enzyme involved in liver fatty acid oxidation, but less is known about its recently discovered role in promoting vascular calcification, and whether CROT-dependent
Externí odkaz:
https://doaj.org/article/59d59852e3244becb85811d9c1542387
Autor:
Samantha K. Atkins, Abhijeet R. Sonawane, Romi Brouwhuis, Johana Barrientos, Anna Ha, Maximillian Rogers, Takeshi Tanaka, Takehito Okui, Shiori Kuraoka, Sasha A. Singh, Masanori Aikawa, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Cardiovascular calcification is the lead predictor of cardiovascular events and the top cause of morbidity and mortality worldwide. To date, only invasive surgical options are available to treat cardiovascular calcification despite the growing unders
Externí odkaz:
https://doaj.org/article/b26ad268a87d40c4af998ae76d91abbc
Autor:
Takeshi Tanaka, Takaharu Asano, Takehito Okui, Shiori Kuraoka, Sasha A. Singh, Masanori Aikawa, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
Vascular calcification is a cardiovascular disorder with no therapeutic options. We recently reported that o-octanoyltransferase (CROT) suppression can inhibit vascular calcification in vivo and in vitro through amelioration of mitochondrial function
Externí odkaz:
https://doaj.org/article/3aa72124cf314fb8aa57e1c137cf026a
Publikováno v:
Biology Open, Vol 2, Iss 10, Pp 1057-1069 (2013)
Summary The African clawed frog, Xenopus laevis, is an ectothermic vertebrate that can survive at low environmental temperatures. To gain insight into the molecular events induced by low body temperature, liver proteins were evaluated at the standard
Externí odkaz:
https://doaj.org/article/9b570a809a6f4202b811ccc2447710a5
Publikováno v:
Development, Growth & Differentiation. 65:94-99
Autor:
Takehito Okui, Masaya Iwashita, Maximillian A Rogers, Shiori Kuraoka, Arda Halu, Yoshikazu Sawada, Masanori Aikawa, Sasha A Singh, Elena Aikawa
Publikováno v:
Circulation. 144
Background: Cardiovascular calcification is a critical pathology associated with increased cardiovascular risk, but there are no FDA-approved anti-calcification therapies. Through an unbiased screening approach, we previously identified carnitine O-o
Autor:
Takeshi Tanaka, Takaharu Asano, Takehito Okui, Shiori Kuraoka, Sasha A Singh, Masanori Aikawa, Elena Aikawa
Publikováno v:
Circulation. 144
Introduction: Vascular calcification is cardiovascular disorder which has no therapeutic options. We previously reported that O-octanoyltransferase (CROT) suppression can inhibit calcification in vivo and in vitro through ameliorating mitochondrial f
Autor:
Sasha A Singh, Ilyes Abdelhamid, Arda Halu, Shiori Kuraoka, Hideyuki Higashi, Samantha K. Atkins, Masanori Aikawa, Masaya Iwashita, Elena Aikawa, Maximillian A. Rogers, Takehito Okui, Ashisha Ramsaroop
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no Food and Drug Administration-approved anticalcific therapies. We hypothesized and validated that an unbiased screening app
Autor:
Takashi Kato, Sakiko Hosozawa, Shun Maekawa, Takehito Okui, Satoka Kohama, Shingo Fujiyama, Hiroshi Muto
Publikováno v:
Zoological Science. 33:575-582
Erythroid progenitors that respond to erythropoietin (Epo) are present in the liver of adult Xenopus laevis. However, cells responding to Epo in the larval liver and through the metamorphosis period under hepatic remodeling have not been characterize
Autor:
Florian Schlotter, Hideyuki Higashi, Elena Aikawa, Maximillian A. Rogers, Takehito Okui, Sasha A Singh, Stephanie Morgan, Lang H Lee, Lixiang Wang, Alan Daugherty, Masanori Aikawa, Masatoshi Nomura, Yukiyoshi Yamazaki, Joshua D. Hutcheson, Arda Halu, Claudia Goettsch
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Objective: Dysfunctional protein homeostasis (proteostasis) contributes to cardiovascular and metabolic disorders. We and others associated the mitochondrial fission protein, Dynamin-related protein 1 (DRP1) with cardiometabolic disease. Liver DRP1-d