Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Takehito Okubo"'
Publikováno v:
Alcoholism: Clinical and Experimental Research. 26:2s-5s
Background: Cholecystokinin (CCK) plays an important role in the function of the central nervous system by interacting with dopamine and other neurotransmitters. We previously reported genetic variations in the promoter and coding regions of the CCKA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d01190b3d3926b6594664b7d69a88d
https://doi.org/10.1111/j.1530-0277.2002.tb02693.x
https://doi.org/10.1111/j.1530-0277.2002.tb02693.x
Autor:
Yoichi Kawanishi, Koubun Imai, Takashi Asada, Hirokazu Tachikawa, Takehito Okubo, Shoji Harada
Publikováno v:
American Journal of Medical Genetics. 114:605-608
The human γ-aminobutyric acid type B (GABAB) receptor gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiologic roles. In the present study, association analyses of genetic polymorphisms of the GABAB receptor gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81989b1bd70b6057cbbb462b5f5e1d0f
https://doi.org/10.1002/ajmg.10605
https://doi.org/10.1002/ajmg.10605
Publikováno v:
Psychiatry Research. 103:147-155
Cholecystokinin A receptors (CCKAR) modulate CCK-stimulated dopamine release, and mutations in the CCKAR gene may predispose affected individuals to schizophrenia. Our previous study suggested that -286A>G polymorphism (previously named 201A>G) in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34df4f7f67f66fcbc1b79e570b9b444
https://doi.org/10.1016/s0165-1781(01)00276-1
https://doi.org/10.1016/s0165-1781(01)00276-1
Autor:
Takehito Okubo, Shoji Harada
Publikováno v:
Journal of Studies on Alcohol. 62:413-421
Cholecystokinin (CCK) plays an important role in the functioning of the central nervous system via an interaction with dopamine and other neurotransmitters. The dopaminergic system has been implicated in the maladaptive behaviors associated with drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be76f22c2008ce76b439906ce891594
https://doi.org/10.15288/jsa.2001.62.413
https://doi.org/10.15288/jsa.2001.62.413
Autor:
Toshihito Suzuki, Takehito Okubo, Hirokazu Tachikawa, Yoichi Kawanishi, Koubun Imai, Shoji Harada
Publikováno v:
Neuropsychobiology. 43:237-241
The human synapsin III gene, located on chromosome 22q12–13, has previously been reported to indicate a susceptibility for schizophrenia. Noval rare variants (Thr136Thr in exon 3, Pro468Ser, Glu525Gln and Pro534Leu in exon 12, and 1769 G/C in the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8205f61124529f73a14b26432c06720e
https://doi.org/10.1159/000054896
https://doi.org/10.1159/000054896
Publikováno v:
Journal of Human Genetics. 45:24-30
The transcription factor activator protein 2 (AP-2) gene is a possible candidate gene for schizophrenia, since it maps near D6S470, a marker on chromosome 6p24 that provided evidence of linkage to schizophrenia. In the present study we analyzed the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8589e3d02badda38d0a12c50e7bfd413
https://doi.org/10.1007/s100380050005
https://doi.org/10.1007/s100380050005
Autor:
Mikihiro Tsutsumi, Chieko Fujii, Fumio Nomura, Shoji Harada, Takehito Okubo, Takako Nakamura, Susumu Higuchi
Publikováno v:
Alcoholism: Clinical and Experimental Research. 23:958-962
Background: Human mitochondrial aldehyde dehydrogenase (ALDH2) is a major enzyme responsible for the oxidation of acetaldehyde derived from ethanol metabolism. The human ALDH2 gene shows genetic polymorphism at position 1510 with a G to A transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90695a60e1c385f7c05b98b6dd2d0354
https://doi.org/10.1111/j.1530-0277.1999.tb04212.x
https://doi.org/10.1111/j.1530-0277.1999.tb04212.x
Publikováno v:
American Journal of Medical Genetics. 81:434-439
Dysfunction of serotonin systems has been implicated in schizophrenia. In the present study, the human 5-HT1A receptor gene containing the 5' untranslated region was screened in order to detect genetic variations, through which alteration of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3de35590204b65b2338fba1832a89d
https://doi.org/10.1002/(sici)1096-8628(19980907)81:5<434::aid-ajmg13>3.0.co
https://doi.org/10.1002/(sici)1096-8628(19980907)81:5<434::aid-ajmg13>3.0.co
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:93S-96S
Neuropeptide cholecystokinin (CCK) and the CCK receptors in the central nervous system mediate actions on increasing firings, anxiety, and nociceptions. Furthermore, CCK modulates the release of dopamine and dopamine-related behaviors in the mesolimb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911c0c89fe60a612722d3904e9719070
https://doi.org/10.1111/acer.1998.22.s3_part1.93s
https://doi.org/10.1111/acer.1998.22.s3_part1.93s
Publikováno v:
Alcoholism: Clinical and Experimental Research. 24:2S-4S
Background: Cholecystokinin (CCK) is considered to play an important role in the central nervous system via its interaction with other neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid, substance P, and enkephalins. We investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e95749c590297195b409cb392d31a6
https://doi.org/10.1111/j.1530-0277.2000.tb00002.x
https://doi.org/10.1111/j.1530-0277.2000.tb00002.x