Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Takehito OHTSUBO"'
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Akademický článek
Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes
Autor: Yuko Takeba, Naoki Matsumoto, Sachiko Takenoshita-Nakaya, Yoshie Harimoto, Toshio Kumai, Yuichi Kinoshita, Hiroshi Nakano, Takehito Ohtsubo, Shinichi Kobayashi
Publikováno v: Journal of Pharmacological Sciences, Vol 115, Iss 4, Pp 516-524 (2011)
The aim of this study was to determine suitable culture conditions for maintaining the activity of cytochrome p450 (CYP) 3A4 and drug transporters in primary cultured human hepatocytes. Human hepatocytes were isolated using the two-step collagenase p
Externí odkaz: https://doaj.org/article/45a08d49106d44c8a726637f1bee7f15
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6
Evaluation of CYP2D6 Protein Expression and Activity in the Small Intestine to Determine Its Metabolic Capability in the Japanese Population
Autor: Momoko Kawakami, Shinichi Kobayashi, Yuki Ohta, Yuki Nishimura, Sachiko Takenoshita-Nakaya, Takehito Ohtsubo, Naoki Matsumoto, Naoki Uchida, Shinjiro Kobayashi, Yuko Takeba, Minoru Watanabe, Masayuki Oda
Publikováno v: Biologicalpharmaceutical bulletin. 40(9)
CYP2D6 plays an important role in the metabolism of many drugs such as opioids and antidepressants. Polymorphisms of the CYP2D6 gene are widely observed in the Japanese population, and can affect the first-pass metabolism of orally administered drugs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dab5192183418b5047939f79f4703dd
https://pubmed.ncbi.nlm.nih.gov/28626197
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