Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Takehisa Ohashi"'
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 65:2044-2049
An enzymatically enantioselective ester hydrolysis of prochiral 1,3-diacyloxy-2-substituted-2-propanol to chiral 1-acyloxy-2,3-propanediol was studied. The (R)-monoester was prepared by selection of a suitable lipase and alkyl chain length of the sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571134810f011ddfa3c18fcfac96b162
https://doi.org/10.1271/bbb.65.2044
https://doi.org/10.1271/bbb.65.2044
Publikováno v:
Immunopharmacology. 37:209-220
We recently observed that the soluble recombinant from of sheep LFA-3, termed sLFA-3 is biologically active as determined by E-rosette inhibition and inhibition of human T-cell proliferation in response to the recall antigen. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e932e20a317144bdcac8cf589f06ac37
https://doi.org/10.1016/s0162-3109(97)00050-7
https://doi.org/10.1016/s0162-3109(97)00050-7
Autor:
Tatsumasa Mae, Takehisa Ohashi, K Hosoe, Eisaku Konishi, Takehiko Yamane, Katsuji Yamashita, K Fujii, T Hidaka
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:2749-2755
The pharmacokinetics of 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl) benzoxazinorifamycin (KRM-1648) in rats and dogs given a single oral dose of 3, 30, or 100 mg/kg of body weight were studied. In the rats, the concentrations of KRM-1648 in plasma, whol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8125e1b5ad87123e830d3be57867171
https://doi.org/10.1128/aac.40.12.2749
https://doi.org/10.1128/aac.40.12.2749
Autor:
Takayoshi Hidaka, Katsuji Yamashita, Takehisa Ohashi, Tatsumasa Mae, Takehiko Yamane, Kenji Fujii, Kazunori Hosoe
Publikováno v:
Xenobiotica. 26:321-332
1. Three metabolites of the antimicrobial agent 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648) were isolated from dog urine obtained after administration of a single oral dose. These metabolites of KRM-1648 were identified by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37489ce4b5a549a75f10fd65799f0650
https://doi.org/10.3109/00498259609046711
https://doi.org/10.3109/00498259609046711
Autor:
Masakatsu Shibasaki, Won-Sup Kim, Takeyuki Suzuki, Junzo Hasegawa, Hiroaki Sasai, Masaru Mitsuda, Takehisa Ohashi
Publikováno v:
Tetrahedron Letters. 35:6123-6126
Rare earth-Li-BINOL complexes were used to catalyze nitroaldol reactions of optically active α-amino-aldehydes with nitromethane in a highly diastereoselective manner. A typical adduct, (2S, 3S)-3-phthaloylamino-2-hydroxy-1-nitro-4-phenylbutane was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1319575876077196f33b57ad2763cc
https://doi.org/10.1016/0040-4039(94)88093-x
https://doi.org/10.1016/0040-4039(94)88093-x
Publikováno v:
Tetrahedron Letters. 42:3331-3333
A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1caf88ff53d90229ebb66a68e1ff7eba
https://doi.org/10.1016/s0040-4039(01)00425-7
https://doi.org/10.1016/s0040-4039(01)00425-7
Autor:
Hiroaki Sasai, Takeyuki Suzuki, Takehisa Ohashi, Junzo Hasegawa, Won-Sup Kim, Masakatsu Shibasaki, Masaru Mitsuda
Publikováno v:
ChemInform. 26
Rare earth-Li-BINOL complexes were used to catalyze nitroaldol reactions of optically active α-amino-aldehydes with nitromethane in a highly diastereoselective manner. A typical adduct, (2S, 3S)-3-phthaloylamino-2-hydroxy-1-nitro-4-phenylbutane was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9b7601f26a1d72ff888a71e1fb4c029
https://doi.org/10.1002/chin.199501095
https://doi.org/10.1002/chin.199501095
ChemInform Abstract: A Practical Chemoenzymatic Synthesis of a Key Intermediate of Antifungal Agents
Publikováno v:
ChemInform. 32
A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39639cb7400ef455b623e79c72b5f85d
https://doi.org/10.1002/chin.200131131
https://doi.org/10.1002/chin.200131131
Autor:
Junzo Hasegawa, Hidetoshi Kutsuki, Shunichi Maemoto, Satoru Tsuda, Takehisa Ohashi, Masahiro Ogura
Publikováno v:
Agricultural and Biological Chemistry. 54:1819-1827
A novel method for producing optically active 1,2-diols by microbial Stereoinversion was developed. It was found that some microorganisms could convert only (R)-1,2-pentanediol in the racemate to the (S)-enantiomer. Candida parapsilosis produced 27.9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484777a13b38b5c6a66fb0817a4ec6da
https://doi.org/10.1080/00021369.1990.10870226
https://doi.org/10.1080/00021369.1990.10870226
Autor:
Takehisa Ohashi
Publikováno v:
ChemInform. 34
The present situation and the development of Japanese green chemistry are discussed.Subjects to be solved and the strategy to be adopted are discussed. Several examples of industrial biotechnology are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43438e93c9358ee02bca18ed72a302a7
https://doi.org/10.1002/chin.200342290
https://doi.org/10.1002/chin.200342290