Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Takehisa Nakajima"'
Publikováno v:
Bio-Medical Materials and Engineering. 33:159-168
BACKGROUND: Inhalable nanocomposite particles using O/W emulsions were studied. The effect of the composition of the dispersed phase on the nanoparticles in the nanocomposite particles was reported, however, the effect on the inhalation characteristi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b283858a89b826a16700c3dac253b39
https://doi.org/10.3233/bme-211244
https://doi.org/10.3233/bme-211244
Publikováno v:
Pharmaceutical Research. 39:143-152
PurposePulmonary administration of dry drug powder is a considered promising strategy in the treatment of various lung diseases such as tuberculosis and is more effective than systemic medication. However, in the pre-clinical study phase, there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191dab727db2868499be25913d3d5309
https://doi.org/10.1007/s11095-021-03146-1
https://doi.org/10.1007/s11095-021-03146-1
Publikováno v:
Journal of pharmaceutical sciences. 107(7)
First, an elementary osmotic pump (EOP) with a simple structure was prepared using polyethylene oxide (PEO) and NaCl as an excipient, and the influence of the molecular weight (Mw) of PEO on drug release was investigated. In the dissolution test of E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ab1b1c3521eee1e22073cbfe6e63e8
https://pubmed.ncbi.nlm.nih.gov/29548974
https://pubmed.ncbi.nlm.nih.gov/29548974
Autor:
Takehisa, Nakajima, Kimiko, Makino
Publikováno v:
Masui. The Japanese journal of anesthesiology. 64(11)
Skin has been studied as administration site of drug for its systemic effects, since systemic therapeutic agents can be delivered for long time with a controlled ratio, escaping from the first pass effect by liver by the transdermal delivery, which c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29caf5914878977f87836b5e50816a23
https://pubmed.ncbi.nlm.nih.gov/26689064
https://pubmed.ncbi.nlm.nih.gov/26689064
Autor:
Hiroshi Terada, Toshio Inagi, Kimiko Makino, Takehisa Nakajima, Masato Asahiyama, Keishiro Tomoda, Makoto Kanebako, Emi Ohtsuki
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 71:27-35
For the treatment of oral mucositis, carrageenan microspheres containing allopurinol and local anesthetic agents, such as lidocaine hydrochloride, dibucaine hydrochloride and tetracaine hydrochloride were prepared using a spray-drying method. As base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a78e3ae1174966275b5e0edb51ade1
https://doi.org/10.1016/j.colsurfb.2009.01.003
https://doi.org/10.1016/j.colsurfb.2009.01.003
Autor:
Kimiko Makino, Hiroshi Terada, Taizo Hasegawa, Takehisa Nakajima, Keiji Hirota, Kanako Iijima
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 63:209-216
A method for exact determination of phagocytic activity of alveolar macrophage (Mvarphi) cells toward synthetic microspheres (MS) by optical microscopy was developed. We examined the effectiveness of the treatment of Mvarphi samples with trypsin, aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ed18ec93acf8ab113442cf4e2b9639
https://doi.org/10.1016/j.colsurfb.2007.12.002
https://doi.org/10.1016/j.colsurfb.2007.12.002
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 64:70-76
Nanoparticles are expected to be applicable to inhalation as carrier but there exist disadvantages because of their size. Their deposition dose to the lung will be small. To overcome this problem and utilize nanoparticles for inhalation, we have prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d071bc8e4e6998631294da79de2e2ff6
https://doi.org/10.1016/j.colsurfb.2008.01.016
https://doi.org/10.1016/j.colsurfb.2008.01.016
Autor:
Motoko Nishiwaki, Takehisa Nakajima, Takumi Ohkoshi, Yusaku Kawai, Kimiko Makino, Keishiro Tomoda
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 61:138-144
To overcome the disadvantages both of microparticles and nanoparticles for inhalation, we have prepared nanocomposite particles as drug carriers targeting lungs. The nanocomposite particles having sizes about 2.5 microm composed of sugar and drug-loa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789abc3756cf981ba17ae218cf69c1ab
https://doi.org/10.1016/j.colsurfb.2007.07.016
https://doi.org/10.1016/j.colsurfb.2007.07.016
Autor:
Satoru Goto, Kemmaro Shimakura, Takehisa Nakajima, Kimiko Makino, Issei Takeuchi, Hideki Kuroda
Publikováno v:
Journal of pharmaceutical sciences. 104(12)
Crystalline state of pharmaceutical materials is of great importance in preparation of pharmaceutics, because their physicochemical properties affect bioavailability, quality of products, therapeutic level and manufacturing process. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca13099b9551ad387032477fa3406c58
https://pubmed.ncbi.nlm.nih.gov/26461839
https://pubmed.ncbi.nlm.nih.gov/26461839
Autor:
Fuminori Ito, Mitsuhiko Shikamura, Kimiko Makino, Hiroyuki Inagawa, Shizutoshi Ando, Hiroshi Terada, Gen-Ichiro Soma, Chie Kochi, Takehisa Nakajima
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 36:35-42
Monodispersed PLGA microspheres containing rifampicin (RFP) have been prepared by solvent evaporation method using a Shirasu porous glass (SPG) membrane. The microspheres were spherical and their average diameter was about 2 microm. The loading effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14a7a3b95efff9fa85dbc7529650c79
https://doi.org/10.1016/j.colsurfb.2004.03.018
https://doi.org/10.1016/j.colsurfb.2004.03.018