Výsledky vyhledávání - "Takehisa, Ishii"

3β-Hydroxysteroid-Δ24 Reductase Is a Hydrogen Peroxide Scavenger, Protecting Cells from Oxidative Stress-Induced Apoptosis

Autor: Yasuko Kozaki, Xiuli Lu, Fukushi Kambe, Hisao Seo, Takahide Kaji, Takehisa Ishii, Xia Cao

Publikováno v: Endocrinology. 149:3267-3273

3beta-Hydroxysteroid-Delta24 reductase (DHCR24) is an endoplasmic reticulum-resident, multifunctional enzyme that possesses antiapoptotic and cholesterol-synthesizing activities. To clarify the molecular basis of the former activity, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8703378fb5d06cb9302f549fe45c1d
https://doi.org/10.1210/en.2008-0024

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DHCR24-Knockout Embryonic Fibroblasts Are Susceptible to Serum Withdrawal-Induced Apoptosis Because of Dysfunction of Caveolae and Insulin-Akt-Bad Signaling

Autor: Hisao Seo, Takahide Kaji, Takehisa Ishii, Xiuli Lu, David Zadworny, Kohji Murakami, Taemi Yoshida, Sachiko Ohmori, Xia Cao, Fukushi Kambe

Publikováno v: Endocrinology. 147:3123-3132

The DHCR24 gene encodes an enzyme catalyzing the last step of cholesterol biosynthesis, the conversion of desmosterol to cholesterol. To elucidate the physiological significance of cholesterol biosynthesis in mammalian cells, we investigated prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa704f6c9c9cb1df00de963c2714399
https://doi.org/10.1210/en.2005-1426

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Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-γ

Autor: Eiichi Gohda, Itaru Yamamoto, Hirohito Tsubouchi, Yoichiro Takami, Kayoko Kanasaki, Takehisa Ishii

Publikováno v: Biochemical and Biophysical Research Communications. 325:676-682

Hepatocyte growth factor (HGF) is one of the vital factors for liver regeneration. HGF production is induced by the activation of protein kinase A and protein kinase C-mediated pathways, interleukin (IL)-1, tumor necrosis factor (TNF)-alpha, and epid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594f59d2022338229b3b1598ae2d9512
https://doi.org/10.1016/j.bbrc.2004.10.093

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DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells

Autor: Shigeo Uchino, Takeshi Hioki, Sadayo Nakajima-Iijima, Takehisa Ishii, Mutsuya Yamamoto

Publikováno v: European Journal of Biochemistry. 269:139-147

Exposure of PC12 cells to C(2)-ceramide results in dose- dependent apoptosis. Here, we investigate the involvement of death-associated protein (DAP) kinase, initially identified as a positive mediator of the interferon-gamma-induced apoptosis of HeLa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35892358a62f2266d89cf783fbd80702
https://doi.org/10.1046/j.0014-2956.2002.00029.x

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Developmental changes in distribution of death-associated protein kinase mRNAs

Autor: Shin Nagayama, Mutsuya Yamamoto, Xiaofen Sun, Takeshi Hioki, Hiroshi Takahashi, Shigeo Uchino, Sadayo Nakajima-Iijima, Noriko Ooashi, Takehisa Ishii, Takeshi Nakamura, Yoshihisa Kudo, Adi Kimchi

Publikováno v: Journal of Neuroscience Research. 58:674-683

Death-associated protein kinase (DAP-kinase) is Ca2+/calmodulin-dependent serine/threonine kinase that contains ankyrin repeats and the death domain. It has been isolated as a positive mediator of interferon-γ-induced apoptotic cell death of HeLa ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c579590f9e98a434e9e1091ab2f37ff0
https://doi.org/10.1002/(sici)1097-4547(19991201)58:5<674::aid-jnr8>3.0.co

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Isolation and Conformational Analysis of Fragment Peptide Corresponding to the Heparin-Binding Site of Hepatocyte Growth Factor

Autor: Yoshiko Yoshiyama, Masayuki Mitsuka, Tetsuo Hayase, Hideyuki Aoyama, Daiji Naka, Takehisa Ishii, Jun Kondo

Publikováno v: Biochemistry. 36:10286-10291

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes. The mitogenic activity of HGF is mediated by its binding to a high-affinity receptor, c-Met. Heparan sulfate is an initial binding site for HGF, based on its relative abundance on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4b8f44fa921ff15622bfa399c570da
https://doi.org/10.1021/bi962700f

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Crystallization and preliminary X-ray analysis of two inhibitor complexes of the catalytic domain of death-associated protein kinase

Autor: Akira Yamakawa, Hiromi Sanuki, Naoki Shibata, Yamada Kazunori, Naoko Andou, Kumiko Morita, Takeshi Hioki, Takehisa Ishii, Hideaki Ogata, Yoshiki Higuchi

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 60:764-766

The catalytic domain of death-associated protein kinase (DAPK) has been overexpressed, purified and crystallized using the sitting-drop vapour-diffusion method with PEG 8000 and magnesium acetate as precipitants. Complexes with the inhibitor staurosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8168ac5513b571093f7a3fa24eec1b3
https://doi.org/10.1107/s0907444904003014

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Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases

Autor: Osamu Nakamura, Takehisa Ishii, Hiroomi Miyazaki, Tomokazu Ohnishi, Shuichi Kawakami, Hirohito Tsubouchi, Naokatu Arakaki, Yasushi Daikuhara

Publikováno v: Hepatology. 22:1728-1734

Human hepatocyte growth factor (hHGF), which is now known to be the same protein as the scatter factor and the tumor cytotoxic factor, is a heterodimeric protein with one heavy chain and one light chain linked together by a disulfide bond, and is tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13e69b8313e25b95b426a7be17b5304
https://doi.org/10.1002/hep.1840220618

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Hepatocyte Growth Factor Stimulates Liver Regeneration and Elevates Blood Protein Level in Normal and Partially Hepatectomized Rats

Autor: Keiko Sudo, Maki Sato, Takehisa Ishii, Masayuki Suzuki, Kohei Umezu, Tadashi Hishida, Satoshi Yuasa, Hiroshi Nakai, Takuro Niwa

Publikováno v: The Journal of Biochemistry. 117:1105-1112

The effects of recombinant human hepatocyte growth factor (HGF) on liver growth and function of normal and partially hepatectomized rats have been examined. HGF was continuously administered into the jugular vein because it was rapidly eliminated fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f243cb51795cfdfe62acd214fe598731
https://doi.org/10.1093/oxfordjournals.jbchem.a124814

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Hepatocyte Growth Factor Immobilized onto Culture Substrates through Heparin and Matrigel Enhances DNA Synthesis in Primary Rat Hepatocytes

Autor: Shigemi Kato, Hiroto Hara, Nobu Akamatsu, Takehisa Ishii, Koji Kimata, Nobuo Sugiura

Publikováno v: Experimental Cell Research. 211:53-58

Newly prepared phosphatidylethanolamine (PE) conjugates of glycosaminoglycans can be immobilized to solid phase through hydrophobic interaction. Primary rat hepatocytes were cultured on type I collagen or laminin substrates containing heparin-PE and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5446c3287129fbce42871327764b0638
https://doi.org/10.1006/excr.1994.1058

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