Výsledky vyhledávání - "Takehiro Yasukawa"

Akademický článek

Increased RUNX3 expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts

Publikováno v: Cancer Medicine, Vol 12, Iss 17, Pp 18062-18077 (2023)

Abstract Background Cancer‐associated fibroblasts (CAFs) are a major stromal component of human breast cancers and often promote tumor proliferation, progression and malignancy. We previously established an experimental CAF (exp‐CAF) cell line eq

Externí odkaz: https://doaj.org/article/96ae5b868f724f33af3c3e73ed1001ff

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Akademický článek

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

Autor: Shigeru Matsuda, Takehiro Yasukawa, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Abstract Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains controversial. Herein, we exhaustively analysed mouse mtDNA using three method

Externí odkaz: https://doaj.org/article/292dcfe424644832b38fb2830dc1be9a

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Akademický článek

Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report

Autor: Satomi Mezuki, Kenji Fukuda, Tomonaga Matsushita, Yoshihisa Fukushima, Ryu Matsuo, Yu-ichi Goto, Takehiro Yasukawa, Takeshi Uchiumi, Dongchon Kang, Takanari Kitazono, Tetsuro Ago

Publikováno v: BMC Neurology, Vol 17, Iss 1, Pp 1-5 (2017)

Abstract Background Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, is the most common phenotype of mitochondrial disease. It often develops in childhood or adolescence, usually before the age of 40,

Externí odkaz: https://doaj.org/article/9b82b4218428407c87fd472efa328800

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Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation

Autor: Haruna Tani, Kaori Ishikawa, Hiroaki Tamashiro, Emi Ogasawara, Takehiro Yasukawa, Shigeru Matsuda, Akinori Shimizu, Dongchon Kang, Jun-Ichi Hayashi, Fan-Yan Wei, Kazuto Nakada

Publikováno v: Nucleic Acids Research. 50:9382-9396

Mitochondrial tRNAs are indispensable for the intra-mitochondrial translation of genes related to respiratory subunits, and mutations in mitochondrial tRNA genes have been identified in various disease patients. However, the molecular mechanism under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bc9f2ad289a47fa24865e8a540b79c
https://doi.org/10.1093/nar/gkac699

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Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication

Autor: Tomoko, Nomiyama, Daiki, Setoyama, Takehiro, Yasukawa, Dongchon, Kang

Publikováno v: The Journal of Biochemistry. 171:325-338

Mitochondrial DNA (mtDNA) replication is tightly regulated and necessary for cellular homeostasis; however, its relationship with mitochondrial metabolism remains unclear. Advances in metabolomics integrated with the rapid isolation of mitochondria w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64eead43746df3883209dc8d91e8f39
https://doi.org/10.1093/jb/mvab136

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Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability

Autor: Goro Doi, Satoshi Okada, Dongchon Kang, Siqin Bala, Shintaro Miyazaki, Takashi Ito, Takehiro Yasukawa, Yuki Sugiyama

Publikováno v: Nucleic Acids Research

Catalytically inactive Cas9 (dCas9) has become an increasingly popular tool for targeted gene activation/inactivation, live-cell imaging, and base editing. While dCas9 was reported to induce base substitutions and indels, it has not been associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eff97fd379e37122a9c1c375743f91
https://doi.org/10.1093/nar/gkaa1241

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Chemical acetylation of mitochondrial transcription factor A occurs on specific lysine residues and affects its ability to change global DNA topology

Autor: Shigeru Matsuda, Yuan Fang, Masaru Akimoto, Kouta Mayanagi, Atsushi Hatano, Dongchon Kang, Takehiro Yasukawa, Masaki Matsumoto

Publikováno v: Mitochondrion. 53:99-108

Chemical acetylation is postulated to occur in mitochondria. Mitochondrial transcription factor A (TFAM or mtTFA), a mitochondrial transcription initiation factor as well as the major mitochondrial nucleoid protein coating the entire mitochondrial ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c5aaac64abfb360e351469707f9015
https://doi.org/10.1016/j.mito.2020.05.003

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The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit

Autor: Kazuto Nakada, Teppei Inatomi, Yura Do, Shigeru Matsuda, Dongchon Kang, Takehiro Yasukawa

Publikováno v: Mitochondrion. 53:133-139

Human DNA polymerase γ (POLG) is a mitochondria-specific replicative DNA polymerase consisting of a single catalytic subunit, POLGα, and a dimeric accessory subunit, POLGβ. To gain a deeper understanding of the role of POLGβ, we knocked out this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13add946e0640d6816661275ec6a3191
https://doi.org/10.1016/j.mito.2020.05.008

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