Výsledky vyhledávání - "Takehiro Ogasa"

Synthetic study on novel immunosuppressant KF20444

Autor: Kenji Fujino, Yoshiaki Masuda, Iwao Chujo, Shin-ichiro Mohri, Masaji Kasai, Sachiko Kato, Takehiro Ogasa

Publikováno v: Bioorganic & Medicinal Chemistry. 9:3273-3286

The two new synthetic routes to 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5H- benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxylic acid (1), a novel immunosuppressant KF20444, are described. The seven-membered ring construction from 2-[4-(2-fluorophenyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c9fa93df1f93d171446273f48e0f50
https://doi.org/10.1016/s0968-0896(01)00238-3

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Development of a Practical Synthetic Route of a PDE V Inhibitor KF31327

Autor: and Shin-ichiro Mohri, Hitoshi Takami, Masaji Kasai, Takehiro Ogasa, Kenji Fujino, Toshiyuki Atsumi

Publikováno v: Organic Process Research & Development. 5:426-433

An efficient route suitable for a large-scale preparation of KF31327 (1), a potent phosphodiesterase V inhibitor, has been developed. We selected 7-chloro-2,4(1H,3H)-quinazolinedione (15) as a starting material, which gave the desired 6-nitro compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c044eba18508ee4c26c138395b1b805a
https://doi.org/10.1021/op010025y

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Synthetic Process Development of Antitumor Agent KT6587, an Indolocarbazole Alkaloid K252a Derivative

Autor: Masaji Kasai, Masahiko Kinugawa, Yoshiaki Masuda, Takehiro Ogasa,† and, Chikara Murakata, Yukiteru Mimura

Publikováno v: Organic Process Research & Development. 3:131-134

A facile and large-scale preparation process of an antitumor agent KT6587 (2), derived from an indolocarbazole alkaloid K252a (1), has been developed. The new synthetic process requires four steps: (i) selective N-silylation of the amide group of 1 w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b955f5beefbe9a3b7dabf5315bb3e28
https://doi.org/10.1021/op980087x

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Development of Large-scale Synthetic Process for Antitumor Agent EO9

Autor: Masahiko Kinugawa, Hitoshi Arai, Masaji Kasai, Takehiro Ogasa

Publikováno v: Journal of Synthetic Organic Chemistry, Japan. 57:401-406

A convenient large-scale preparation of the indoloquinone antitumor agent EO9 has been developed. A Nenitzescu reaction has been used to prepare the indole skeleton having all functional groups necessary for its conversion into a key intermediate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2e6f9463334dfd4e767060ef1c1e8db
https://doi.org/10.5059/yukigoseikyokaishi.57.401

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Practical Synthesis of the High-Quality Antitumor Agent KW-2189 from Duocarmycin B2 Using a Facile One-Pot Synthesis of an Intermediate

Autor: Yoshiaki Masuda, Masahiko Kinugawa, Takehiro Ogasa,† and, Hiromitsu Saito, Masaji Kasai, Akihiko Sakaguchi, Satoru Nagamura

Publikováno v: Organic Process Research & Development. 2:344-350

A facile and large-scale preparation process of a potent antitumor agent KW-2189 (2), derived from the antitumor antibiotic duocarmycin B2 (1), has been developed. This new synthetic route required three steps: (i) one-pot carbamoylation and subseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9459e78767d0d98af1e8b659435bb0bb
https://doi.org/10.1021/op980038k

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Facile Synthesis of 1,4-Dihydropyridine Monocarboxylic Acids and Unsymmetric DicarboxylatesviaQuaternary Ammonium Salts of 2-Aminoethyl 1,4-Dihydropyridine-3,5-dicarboxylates

Autor: Takehiro Ogasa, Masahiko Kinugawa

Publikováno v: Synthetic Communications. 27:3321-3331

Useful 1,4-dihydropyridine unsymmetric dicarboxylates [nitrendipine (1), nicardipine (2)] and monocarboxylic acid 4 were prepared from unsymmetric 2-aminoethyl methyl 1,4-dihydropyridine-3,5-dicarboxylates 2 and 3 via their corresponding quaternary a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a6379a52363993f3660c0c7fcf8d65f
https://doi.org/10.1080/00397919708005632

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The synthesis of [3H]KW-2189, a novel active antitumor antibiotic

Autor: Satoro Nagamura, Masahiko Kinugawa, Takehiro Ogasa, Hiromitsu Saito

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 39:471-477

The synthesis of [3H]KW-2189, 2, a novel active antitumor antibiotic, is described. The key intermediate, 6, in the synthesis, was synthesized in four steps from duocarmycin B2 (1). Treatment of 6 with [3H]methyl iodide in the presence of NaHCO3 in M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0464678a3f8be3ee904f0e5e72f5c94
https://doi.org/10.1002/(sici)1099-1344(199706)39:6<471::aid-jlcr991>3.0.co

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