Výsledky vyhledávání - "Takehiro Katahira"

Akademický článek

Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factorsResearch in context

Autor: Masaki Miura, Takeshi Miyatsuka, Takehiro Katahira, Shugo Sasaki, Luka Suzuki, Miwa Himuro, Yuya Nishida, Yoshio Fujitani, Taka-aki Matsuoka, Hirotaka Watada

Publikováno v: EBioMedicine, Vol 36, Iss , Pp 358-366 (2018)

Background: STAT3 has been demonstrated to play a role in maintaining cellular identities in the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell function. Methods: The role of STAT3 in β-cell neogenesis, induced by

Externí odkaz: https://doaj.org/article/20f5850a175b4d869092d621298cd32c

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Cumulative autophagy insufficiency in mice leads to progression of β-cell failure

Autor: Luka Suzuki, Takeshi Miyatsuka, Miwa Himuro, Yuka Wakabayashi, Sho Osonoi, Masaki Miura, Takehiro Katahira, Yoshio Fujitani, Hitoshi Iida, Hiroki Mizukami, Yuya Nishida, Hirotaka Watada

Publikováno v: Biochemical and Biophysical Research Communications. 611:38-45

Autophagy is known to play a pivotal role in β-cell function. While the lifelong inhibition of autophagy through Atg7 deletion in β cells has been demonstrated to lead to impaired glucose tolerance together with β-cell dysfunction, the temporal as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c7b4aab2e9775d72e5ca9fdb14a33
https://doi.org/10.1016/j.bbrc.2022.04.040

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Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production

Autor: Yoshio Fujitani, Luka Suzuki, Hirotaka Watada, Satoru Takeda, Atsuo Itakura, Masaya Takahashi, Yuya Nishida, Hiroki Mizukami, Takeshi Miyatsuka, Masaki Miura, Yuka Wakabayashi, Miwa Himuro, Takehiro Katahira, Ayako Fukunaka, Sho Osonoi

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports

Pancreatic β-cell mass is known to be considerably altered during pregnancy and after parturition in rodents and humans. While β-cell mass increases during pregnancy and starts to return toward its original level after parturition, the cellular mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f6fd99c922e6eab6ecad01d31292a2
http://link.springer.com/article/10.1038/s41598-020-61850-1

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Conversion of pancreatic α cells into insulin-producing cells modulated by β-cell insufficiency and supplemental insulin administration

Autor: Hirotaka Watada, Takehiro Katahira, Luka Suzuki, Miwa Himuro, Hiroaki Satoh, Yuya Nishida, Takeshi Miyatsuka, Masaki Miura

Publikováno v: Biochemical and Biophysical Research Communications. 521:178-183

The emergence of bihormonal (BH) cells expressing insulin and glucagon has been reported under diabetic conditions in humans and mice. Whereas lineage tracing studies demonstrated that glucagon-producing α cells can be reprogrammed into BH cells, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01689591693a08ede07b0c9c17c23c74
https://doi.org/10.1016/j.bbrc.2019.10.100

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Effects of Synbiotic Supplementation on Chronic Inflammation and the Gut Microbiota in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study

Autor: Junko Sato, Yuichiro Yamashiro, Takehiro Katahira, Shoko Tamaki, Hideyoshi Kaga, Hirotaka Watada, Tomoaki Shimizu, Hiromasa Goto, Masanori Aida, Akio Kanazawa, Yasuto Yoshida, Takuya Takahashi, Kosuke Azuma, Luka Suzuki

Publikováno v: Nutrients, Vol 13, Iss 558, p 558 (2021)
Nutrients
Volume 13
Issue 2

The aim of this study was to investigate the effects of 24-week synbiotic supplementation on chronic inflammation and the gut microbiota in obese patients with type 2 diabetes. We randomized 88 obese patients with type 2 diabetes to one of two groups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f695cbb0fb32ce885955715c698db56
https://www.mdpi.com/2072-6643/13/2/558

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Postprandial Plasma Glucagon Kinetics in Type 2 Diabetes Mellitus: Comparison of Immunoassay and Mass Spectrometry

Autor: Atsushi Miyachi, Hirotaka Watada, Naoko Takayanagi, Takeshi Miyatsuka, Yuka Tosaka, Fuki Ikeda, Takeshi Ogihara, Tomoya Mita, Chie Ohmura, Satoko Yamashita, Koji Komiya, Mai Shinohara, Takehiro Katahira, Akio Kanazawa, Hideyoshi Kaga, Eri Mieno, Kosuke Azuma, Mami Koshibu

Publikováno v: Journal of the Endocrine Society

Context Accurate glucagon level measurements are necessary for investigation of mechanisms for postprandial hyperglycemia in type 2 diabetes. Objective To evaluate the accuracy of postprandial glucagon level measurements using a sandwich ELISA vs a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2413f081e2a78a12ef0147d7bb3da433
https://doi.org/10.1210/js.2018-00142

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Cellular autophagy in α cells plays a role in the maintenance of islet architecture

Autor: Takehiro Katahira, Yuya Nishida, Masaki Miura, Miwa Himuro, Yoshio Fujitani, Takeshi Miyatsuka, George K. Gittes, Luka Suzuki, Shugo Sasaki, Hirotaka Watada, Hiromasa Goto, Chiyo Shiota, Masato Koike

Publikováno v: Journal of the Endocrine Society

Autophagy is known to play a pivotal role in intracellular quality control through the degradation of subcellular damaged organelles and components. Whereas autophagy is essential for maintaining β-cell function in pancreatic islets, it remains uncl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afa6213ad9c32065539256189d11741
https://doi.org/10.1210/js.2019-00075

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346-LB: The Role of STAT3 Signaling toward a-to-ß Reprogramming within the Adult Pancreas

Autor: Yuka Wakabayashi, Takeshi Miyatsuka, Masaki Miura, Miwa Himuro, Luka Suzuki, Takehiro Katahira, Hirotaka Watada

Publikováno v: Diabetes. 68

As diabetes mellitus results from the absolute or relative deficiency of insulin secretion from pancreatic β cells, the generation of surrogate β cells has attracted a lot of attention for the cure of diabetes. To date, insulin-producing cells have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e85b150aa439fe7ccfb7abf4ecf200
https://doi.org/10.2337/db19-346-lb

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2162-P: Autophagy Deficiency Cumulatively Causes ß-Cell Failure in Mice

Autor: Yuya Nishida, Takeshi Miyatsuka, Yoshio Fujitani, Masaki Miura, Hirotaka Watada, Miwa Himuro, Luka Suzuki, Takehiro Katahira, Koji Komiya

Publikováno v: Diabetes. 68

Autophagy is known to play a pivotal role in intracellular quality control through the degradation of damaged organelles and components. We previously reported that β-cell specific autophagy deficient mice (βAtg7KO), which lack Atg7 in β cells thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c982b0f35dc24d15cbbea40cf5e58617
https://doi.org/10.2337/db19-2162-p

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