Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Takehiro Fukuzaki"'
Publikováno v:
Angewandte Chemie. 128:533-537
D-Desosamine is synthesized in 4 steps from methyl vinyl ketone and sodium nitrite. The key step in this chromatography-free synthesis is the coupling of (R)-4-nitro-2-butanol and glyoxal (trimeric form) mediated by cesium carbonate, which affords in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1871492a91a5875e16aa98c8218c3bc9
https://doi.org/10.1002/ange.201507357
https://doi.org/10.1002/ange.201507357
Autor:
Pavol Jakubec, Peter N. Carlsen, Ian B. Seiple, Filip T. Szczypiński, Peter M. Wright, Kazuo Yabu, William D. Green, Yoshiaki Kitamura, Senkara Rao Allu, Audrey Langlois-Mercier, Andrew G. Myers, Daniel T. Hog, Ziyang Zhang, Xiang Zhou, Takehiro Fukuzaki, Matthew L. Condakes
Publikováno v:
Nature, vol 533, iss 7603
Nature
Nature
The chemical modification of structurally complex fermentation products, a process known as semisynthesis, has been an important tool in the discovery and manufacture of antibiotics for the treatment of various infectious diseases. However, many of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1131e840dbc9c733227cac4f62fc147f
https://escholarship.org/uc/item/4dp8m2jd
https://escholarship.org/uc/item/4dp8m2jd
Publikováno v:
ChemInform. 47
Key step in the synthesis of D-desosamine and analogs (V) is the chromatography-free procedure for the coupling of chiral nitrobutanols (I) with glyoxal to give pure 3-nitro sugars by crystallization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c7ad1eb913b4b5d253f66ba1ef4e973
https://doi.org/10.1002/chin.201620204
https://doi.org/10.1002/chin.201620204
Autor:
Kouichi Nakamura, Takeshi Honda, Jun Tanaka, Jun Ohsumi, Masanori Kuroha, Kenji Wakabayashi, Akihiro Furukawa, Satoko Wakimoto, Tsuyoshi Arita, Yumi Matsui, Shinko Hayashi, Osamu Suzuki, Makoto Mori, Takehiro Fukuzaki, Kazushi Araki, Susumu Satoh
Publikováno v:
European Journal of Medicinal Chemistry. 54:522-533
Selective peroxisome proliferator-activated receptor gamma (PPARγ) modulators are expected to be a novel class of drugs improving plasma glucose levels without PPARγ-related adverse effects. As a continuation of our studies for (-)-Cercosporamide d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075dca2286783ced0f3aeb6e288779bc
https://doi.org/10.1016/j.ejmech.2012.05.040
https://doi.org/10.1016/j.ejmech.2012.05.040
Autor:
Takeshi Honda, Shinko Hayashi, Takehiro Fukuzaki, Kazushi Araki, Kenji Wakabayashi, Jun Ohsumi, Tsuyoshi Arita, Yumi Matsui, Susumu Satoh, Akihiro Furukawa, Makoto Mori
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1348-1351
Peroxisome proliferator-activated receptor gamma (PPARγ) is a potential drug target for treating type 2 diabetes. The selective PPARγ modulators (SPPARMs), which partially activate the PPARγ transcriptional activity, are considered to improve the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcc7bcadad7ac18f5d4a0545c17c1fe
https://doi.org/10.1016/j.bmcl.2011.12.066
https://doi.org/10.1016/j.bmcl.2011.12.066
Publikováno v:
Tetrahedron Letters. 40:1907-1910
An asymmetric synthesis of the tricyclic dihydrofuran moiety of azadirachtin is reported. The Diels-Alder adduct, which was catalyzed by Evans' chiral Cu-bisoxazoline complex, was easily converted to the tricyclic portion via SmI 2 reductive cleavage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e6f7532f60900682e2aa07104735bf
https://doi.org/10.1016/s0040-4039(99)00040-4
https://doi.org/10.1016/s0040-4039(99)00040-4
Publikováno v:
ChemInform. 30
An asymmetric synthesis of the tricyclic dihydrofuran moiety of azadirachtin is reported. The Diels-Alder adduct, which was catalyzed by Evans' chiral Cu-bisoxazoline complex, was easily converted to the tricyclic portion via SmI 2 reductive cleavage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd326b75704690f01a0bb9bb63d00533
https://doi.org/10.1002/chin.199923208
https://doi.org/10.1002/chin.199923208